{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T11:37:38Z","timestamp":1774784258472,"version":"3.50.1"},"reference-count":32,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>\n            PURPOSE: To determine the impact of\n            <jats:italic>MLL<\/jats:italic>\n            rearrangements on the outcome of children with acute myeloid leukemia (AML).\n          <\/jats:p>\n          <jats:p>PATIENTS AND METHODS: We analyzed the clinical and biologic features of 298 infants and children with primary AML treated on four consecutive institutional clinical trials. The Kaplan-Meier method was used in survival analysis and the Cox proportional-hazards model was used to analyze the effect of potential prognostic factors on event-free survival (\u00b1 1 SE).<\/jats:p>\n          <jats:p>\n            RESULTS: Molecular studies of 152 cases detected 42 with\n            <jats:italic>MLL<\/jats:italic>\n            rearrangements. The karyotypes of these 42 revealed the t(9;11) (15 cases), abnormalities of chromosomes 10 and 11 (nine cases), the t(11;19) (four cases), other abnormalities of 11q23 (seven cases), and miscellaneous rearrangements (seven cases). Among these 42 patients, the 15 whose leukemic cells carried the t(9;11) had a better outcome (66% \u00b1 15%) than the other 27 (25.9% \u00b1 11.2%;\n            <jats:italic>P<\/jats:italic>\n            = .004). Cases with the t(9;11) were also characterized by M5 AML morphology (21 of 23 cases). Of the 63 patients with M5 AML, the 21 whose leukemic cells demonstrated the t(9;11) had a better outcome (71.1% \u00b1 11%) than the other 42 (25.8% \u00b1 7.9%;\n            <jats:italic>P<\/jats:italic>\n            = .0004). The only independent factors indicating a favorable prognosis were presenting leukocyte count less than 50 \u00d7 10\n            <jats:sup>9<\/jats:sup>\n            \/L (relative risk of relapse, 0.73; 95% confidence interval, 0.55 to 0.97;\n            <jats:italic>P<\/jats:italic>\n            = .03) and the t(9;11) (relative risk of relapse, 0.32; 95% confidence interval, 0.16 to 0.64;\n            <jats:italic>P<\/jats:italic>\n            = .002).\n          <\/jats:p>\n          <jats:p>CONCLUSION: We conclude that the t(9;11) is the most favorable genetic factor for patients with AML treated at our institution.<\/jats:p>","DOI":"10.1200\/jco.2002.08.023","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:13:48Z","timestamp":1027775628000},"page":"2302-2309","source":"Crossref","is-referenced-by-count":115,"title":["Favorable Impact of the t(9;11) in Childhood Acute Myeloid Leukemia"],"prefix":"10.1200","volume":"20","author":[{"given":"Jeffrey E.","family":"Rubnitz","sequence":"first","affiliation":[{"name":"From the Departments of Hematology-Oncology, Pathology, and Biostatistics, St Jude Children\u2019s Research Hospital; and Department of Pediatrics, University of Tennessee, Memphis, College of Medicine, Memphis, TN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana C.","family":"Raimondi","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology-Oncology, Pathology, and Biostatistics, St Jude Children\u2019s Research Hospital; and Department of Pediatrics, University of Tennessee, Memphis, College of Medicine, Memphis, TN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Tong","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology-Oncology, Pathology, and Biostatistics, St Jude Children\u2019s Research Hospital; and Department of Pediatrics, University of Tennessee, Memphis, College of Medicine, Memphis, TN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deo Kumar","family":"Srivastava","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology-Oncology, Pathology, and Biostatistics, St Jude Children\u2019s Research Hospital; and Department of Pediatrics, University of Tennessee, Memphis, College of Medicine, Memphis, TN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassem I.","family":"Razzouk","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology-Oncology, Pathology, and Biostatistics, St Jude Children\u2019s Research Hospital; and Department of Pediatrics, University of Tennessee, Memphis, College of Medicine, Memphis, TN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila A.","family":"Shurtleff","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology-Oncology, Pathology, and Biostatistics, St Jude Children\u2019s Research Hospital; and Department of Pediatrics, University of Tennessee, Memphis, College of Medicine, Memphis, TN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Downing","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology-Oncology, Pathology, and Biostatistics, St Jude Children\u2019s Research Hospital; and Department of Pediatrics, University of Tennessee, Memphis, College of Medicine, Memphis, TN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Hon","family":"Pui","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology-Oncology, Pathology, and Biostatistics, St Jude Children\u2019s Research Hospital; and Department of Pediatrics, University of Tennessee, Memphis, College of Medicine, Memphis, TN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul C.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology-Oncology, Pathology, and Biostatistics, St Jude Children\u2019s Research Hospital; and Department of Pediatrics, University of Tennessee, Memphis, College of Medicine, Memphis, TN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick G.","family":"Behm","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology-Oncology, Pathology, and Biostatistics, St Jude Children\u2019s Research Hospital; and Department of Pediatrics, University of Tennessee, Memphis, College of Medicine, Memphis, TN."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2322"},{"key":"e_1_3_2_2_2","first-page":"4173","volume":"58","year":"1998","unstructured":"Bloomfield CD, Lawrence D, Byrd JC, et al: Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype. 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