{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:32:27Z","timestamp":1770823947647,"version":"3.50.1"},"reference-count":42,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2002,5,15]]},"abstract":"<jats:p> PURPOSE: In 1992, the Early Breast Cancer Trialists\u2019 Collaborative Group reported that a meta-analysis of six randomized trials in European and North American women begun from 1948 to 1972 demonstrated disease-free and overall survival benefit from adjuvant ovarian ablation. Approximately 350,000 new cases of breast cancer are diagnosed annually in premenopausal Asian women who have lower levels of estrogen than western women. <\/jats:p><jats:p> PATIENTS AND METHODS: From 1993 to 1999, we recruited 709 premenopausal women with operable breast cancer (652 from Vietnam, 47 from China) to a randomized clinical trial of adjuvant oophorectomy and tamoxifen (20 mg orally every day) for 5 years or observation and this combined hormonal treatment on recurrence. At later dates estrogen- and progesterone-receptor protein assays by immunohistochemistry were performed for 470 of the cases (66%). <\/jats:p><jats:p> RESULTS: Treatment arms were well balanced. With a median follow-up of 3.6 years, there have been 84 events and 69 deaths in the adjuvant treatment group and 127 events and 91 deaths in the observation group, with 5-year disease-free survival rates of 75% and 58% (P = .0003 unadjusted; P = .0075 adjusted), and overall survival rates of 78% and 70% (P = .041 unadjusted) for the adjuvant and observation groups, respectively. Only patients with hormone receptor\u2013positive tumors benefited from the adjuvant treatment. In Vietnam, for women unselected for hormone receptor status, a cost-effectiveness analysis suggests that this intervention costs $350 per year of life saved. <\/jats:p><jats:p> CONCLUSION: Vietnamese and Chinese women with hormone receptor\u2013positive operable breast cancer benefit from adjuvant treatment with surgical oophorectomy and tamoxifen. <\/jats:p>","DOI":"10.1200\/jco.2002.08.169","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:13:48Z","timestamp":1027775628000},"page":"2559-2566","source":"Crossref","is-referenced-by-count":80,"title":["Oophorectomy and Tamoxifen Adjuvant Therapy in Premenopausal Vietnamese and Chinese Women With Operable Breast Cancer"],"prefix":"10.1200","volume":"20","author":[{"given":"Richard R.","family":"Love","sequence":"first","affiliation":[{"name":"From the University of Wisconsin Comprehensive Cancer Center, Madison, WI; Hospital K, National Cancer Institute, Ha Noi; Danang General Hospital, Da Nang; Hue Central Hospital, Hue; Hai Phong General Hospital, Hai Phong; Khanh Hoa Provincial Hospital, Nha Trang City, Socialist Republic of Vietnam; People\u2019s Hospital of Haimen City, Haimen, Jiangsu, People\u2019s Republic of China; Baylor College of Medicine, Houston, TX; and Virginia Commonwealth University, Richmond, VA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Ba","family":"Duc","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin Comprehensive Cancer Center, Madison, WI; Hospital K, National Cancer Institute, Ha Noi; Danang General Hospital, Da Nang; Hue Central Hospital, Hue; Hai Phong General Hospital, Hai Phong; Khanh Hoa Provincial Hospital, Nha Trang City, Socialist Republic of Vietnam; People\u2019s Hospital of Haimen City, Haimen, Jiangsu, People\u2019s Republic of China; Baylor College of Medicine, Houston, TX; and Virginia Commonwealth University, Richmond, VA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Craig","family":"Allred","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin Comprehensive Cancer Center, Madison, WI; Hospital K, National Cancer Institute, Ha Noi; Danang General Hospital, Da Nang; Hue Central Hospital, Hue; Hai Phong General Hospital, Hai Phong; Khanh Hoa Provincial Hospital, Nha Trang City, Socialist Republic of Vietnam; People\u2019s Hospital of Haimen City, Haimen, Jiangsu, People\u2019s Republic of China; Baylor College of Medicine, Houston, TX; and Virginia Commonwealth University, Richmond, VA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Cong","family":"Binh","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin Comprehensive Cancer Center, Madison, WI; Hospital K, National Cancer Institute, Ha Noi; Danang General Hospital, Da Nang; Hue Central Hospital, Hue; Hai Phong General Hospital, Hai Phong; Khanh Hoa Provincial Hospital, Nha Trang City, Socialist Republic of Vietnam; People\u2019s Hospital of Haimen City, Haimen, Jiangsu, People\u2019s Republic of China; Baylor College of Medicine, Houston, TX; and Virginia Commonwealth University, Richmond, VA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Van","family":"Dinh","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin Comprehensive Cancer Center, Madison, WI; Hospital K, National Cancer Institute, Ha Noi; Danang General Hospital, Da Nang; Hue Central Hospital, Hue; Hai Phong General Hospital, Hai Phong; Khanh Hoa Provincial Hospital, Nha Trang City, Socialist Republic of Vietnam; People\u2019s Hospital of Haimen City, Haimen, Jiangsu, People\u2019s Republic of China; Baylor College of Medicine, Houston, TX; and Virginia Commonwealth University, Richmond, VA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Ngoc","family":"Kha","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin Comprehensive Cancer Center, Madison, WI; Hospital K, National Cancer Institute, Ha Noi; Danang General Hospital, Da Nang; Hue Central Hospital, Hue; Hai Phong General Hospital, Hai Phong; Khanh Hoa Provincial Hospital, Nha Trang City, Socialist Republic of Vietnam; People\u2019s Hospital of Haimen City, Haimen, Jiangsu, People\u2019s Republic of China; Baylor College of Medicine, Houston, TX; and Virginia Commonwealth University, Richmond, VA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Van","family":"Thuan","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin Comprehensive Cancer Center, Madison, WI; Hospital K, National Cancer Institute, Ha Noi; Danang General Hospital, Da Nang; Hue Central Hospital, Hue; Hai Phong General Hospital, Hai Phong; Khanh Hoa Provincial Hospital, Nha Trang City, Socialist Republic of Vietnam; People\u2019s Hospital of Haimen City, Haimen, Jiangsu, People\u2019s Republic of China; Baylor College of Medicine, Houston, TX; and Virginia Commonwealth University, Richmond, VA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed K.","family":"Mohsin","sequence":"additional","affiliation":[{"name":"From the University of Wisconsin Comprehensive Cancer Center, Madison, WI; 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