{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:54:00Z","timestamp":1782507240597,"version":"3.54.5"},"reference-count":49,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>PURPOSE: Cancer is, unfortunately, often a terminal disease. The goal of therapy for many patients with cancer is palliation of symptoms common at the end of life, including pain, depression, and cognitive dysfunction. Methylphenidate is a psychostimulant most commonly used in the treatment of attention deficit hyperactivity disorder. In this report, we review the use of methylphenidate in the palliative care of patients with cancer.<\/jats:p><jats:p>METHODS: This review was written on the basis of a computerized literature search of Medline. We considered all English language publications from 1966 to present using the following key words: methylphenidate, palliative care, and cancer. Forty-nine articles were identified as being relevant for this review.<\/jats:p><jats:p>RESULTS: On the basis of this review, we came to the conclusion that methylphenidate is used to ameliorate opioid-induced somnolence, to augment the analgesic effects of opioids, to treat depression, and to improve cognitive function in patients with cancer.<\/jats:p><jats:p>CONCLUSION: The medical literature supports the palliative use of methylphenidate in the care of patients with cancer. Further placebo-controlled trials are needed to elucidate the precise role that methylphenidate will have in providing symptom relief to dying patients.<\/jats:p>","DOI":"10.1200\/jco.2002.20.1.335","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:38:26Z","timestamp":1487896706000},"page":"335-339","source":"Crossref","is-referenced-by-count":166,"title":["Palliative Uses of Methylphenidate in Patients With Cancer: A Review"],"prefix":"10.1200","volume":"20","author":[{"given":"Mark","family":"Rozans","sequence":"first","affiliation":[{"name":"From the Departments of Medicine and Pharmacology, Tulane University School of Medicine, New Orleans, LA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Dreisbach","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and Pharmacology, Tulane University School of Medicine, New Orleans, LA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.L.","family":"Lertora","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and Pharmacology, Tulane University School of Medicine, New Orleans, LA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J.","family":"Kahn","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and Pharmacology, Tulane University School of Medicine, New Orleans, LA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.41.1.19"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/15563659709001195"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)64618-1"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(05)70304-X"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050267"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1985.tb05524.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90724-1"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90066-6"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90869-U"},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0026-895X(25)08574-8","volume":"47","year":"1995","unstructured":"Wall SC, Gu H, Rudnick G: Biogenic amine flux mediated by clonal transporters stably expressed in culture dell lines: Amphetamine specificity for inhibition and efflux. 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