{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:22:29Z","timestamp":1791296549695,"version":"4.1.0"},"reference-count":30,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:p> Purpose: To compare pediatric and adult therapeutic practices in the treatment of acute lymphoblastic leukemia (ALL) in adolescents. <\/jats:p><jats:p> Patients and Methods: From June 1993 to September 1994, 77 and 100 adolescents (15 to 20 years of age) were enrolled in the pediatric FRALLE-93 and adult LALA-94 protocols, respectively. Among the different prognostic factors, we retrospectively analyzed the effect of the trial on achieving complete remission (CR) and event-free survival (EFS). <\/jats:p><jats:p> Results: Patients were younger in the FRALLE-93 than in the LALA-94 protocol (median age, 15.9 v 17.9 years, respectively), but other characteristics were similar, including median WBC count (18 \u00d7 10<jats:sup>9<\/jats:sup> cells\/L v 16 \u00d7 10<jats:sup>9<\/jats:sup> cells\/L), B\/T-lineage (54 of 23 v 72 of 28 patients), CD10-negative ALL (13% v 15%), and poor-risk cytogenetics (t(9;22), t(4;11), or hypodiploidy less than 45 chromosomes: 6% v 5%). The CR rate depended on WBC count (P = .005) and trial (94% v 83% in FRALLE-93 and LALA-94, respectively; P = .04). Univariate analysis showed that unfavorable prognostic factors for EFS were as follows: the trial (estimated 5-year EFS, 67% v 41% for FRALLE-93 and LALA-94, respectively; P &lt; .0001), an increasing WBC count (P &lt; .0001), poor-risk cytogenetics (P = .005), and T-lineage (P = .01). The trial and WBC count remained significant parameters for EFS in multivariate analysis (P &lt; .0001 and P = .0004). Lineage subgroup analysis showed an advantage for the FRALLE-93 trial for CR achievement (98% v 81%; P = .002) and EFS (P = .0002) in B-lineage ALL and for EFS (P = .05) in T-lineage ALL. Age was not a significant prognostic factor in this population of adolescents. <\/jats:p><jats:p> Conclusion: This study\u2019s findings indicate that adolescents should be included in intensive pediatric protocols and that new trials should be designed, inspired by pediatric protocols, for the treatment of young adults with ALL. <\/jats:p>","DOI":"10.1200\/jco.2003.02.053","type":"journal-article","created":{"date-parts":[[2003,5,13]],"date-time":"2003-05-13T05:31:54Z","timestamp":1052803914000},"page":"774-780","source":"Crossref","is-referenced-by-count":511,"title":["Should Adolescents With Acute Lymphoblastic Leukemia Be Treated as Old Children or Young Adults? Comparison of the French FRALLE-93 and LALA-94 Trials"],"prefix":"10.1200","volume":"21","author":[{"given":"Nicolas","family":"Boissel","sequence":"first","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Fran\u00e7oise","family":"Auclerc","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Lh\u00e9ritier","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Perel","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Thomas","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Leblanc","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; 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Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Cayuela","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; 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Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Piguet","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Huguet-Rigal","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; 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Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Pautas","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Michel","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; 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Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Dombret","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; Service d\u2019H\u00e9matologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Baruchel","sequence":"additional","affiliation":[{"name":"From the Services d\u2019H\u00e9matologie P\u00e9diatrique et Adulte, Laboratoire Central d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis; Service d\u2019Onco-H\u00e9matologie, H\u00f4pital Trousseau, Paris; Service d\u2019H\u00e9matologie, H\u00f4pital Edouard Herriot, Lyon; Unit\u00e9 d\u2019Onco-H\u00e9matologie P\u00e9diatrique, H\u00f4pital des Enfants, Bordeaux; Laboratoire de Biochimie et de Biologie Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine Nord, Marseille; Service d\u2019H\u00e9matologie, H\u00f4pital Lapeyronie, Montpellier; Service d\u2019H\u00e9matologie, H\u00f4pital Dupuytren, Limoges; 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