{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:26:31Z","timestamp":1790835991884,"version":"4.1.0"},"reference-count":24,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2003,12,1]]},"abstract":"<jats:p> Purpose: To conduct a prospective study of intraperitoneal radioactive chromic phosphate (<jats:sup>32<\/jats:sup>P) versus cyclophosphamide-cisplatin (CP) in women with early ovarian cancer at high risk for recurrence (International Federation of Gynecology and Obstetrics stage Ia or Ib grade 3 or Ic or stage II, no macroscopic residual disease) and to compare cumulative incidence of recurrence, overall survival, and relative toxicity. <\/jats:p><jats:p> Materials and Methods: A total of 251 patients were randomly assigned to treatment with <jats:sup>32<\/jats:sup>P or CP. Twenty-two (8.7%) were ineligible following centralized pathology review. Of the 229 patients included in the analysis, 110 received <jats:sup>32<\/jats:sup>P, and 119 received CP. <\/jats:p><jats:p> Results: The cumulative incidence of recurrence at 10 years was 35% (95% CI, 27% to 45%) for patients receiving <jats:sup>32<\/jats:sup>P and 28% (95% CI, 21% to 38%) for those receiving CP. Patients receiving CP had a recurrence rate 29% lower than that of those receiving <jats:sup>32<\/jats:sup>P (P = .15, two-tail test). The death rate for patients treated with CP was 17% lower than that for patients treated with <jats:sup>32<\/jats:sup>P (difference not significant). Combining both arms, the 10-year cumulative incidence of recurrence for all stage I patients was 27% (95% CI, 20% to 34%) compared with 44% (95% CI, 32% to 56%) for stage II patients (P = .01). Both regimens were reasonably well tolerated, but problems with inadequate distribution (7%) and small-bowel perforation (3%) make the otherwise less toxic <jats:sup>32<\/jats:sup>P less acceptable. <\/jats:p><jats:p> Conclusion: Although there are no statistically significant differences in survival, the lower cumulative recurrence seen with CP and complications of <jats:sup>32<\/jats:sup>P administration make platinum-based combinations the preferred adjuvant therapy for early ovarian cancer patients at high-risk for recurrence. <\/jats:p>","DOI":"10.1200\/jco.2003.02.154","type":"journal-article","created":{"date-parts":[[2003,11,26]],"date-time":"2003-11-26T01:39:00Z","timestamp":1069810740000},"page":"4350-4355","source":"Crossref","is-referenced-by-count":91,"title":["Adjuvant Treatment for Early Ovarian Cancer: A Randomized Phase III Trial of Intraperitoneal <sup>32<\/sup>P or Intravenous Cyclophosphamide and Cisplatin\u2014A Gynecologic Oncology Group Study"],"prefix":"10.1200","volume":"21","author":[{"given":"Robert C.","family":"Young","sequence":"first","affiliation":[{"name":"From the Fox Chase Cancer Center, Philadelphia, PA; Roswell Park Cancer Institute, Buffalo, NY; University of California Los Angeles Medical Center, Los Angeles, CA, Mayo Comprehensive Cancer Center, Rochester, MN; Walter Reed Army Medical Center, Washington, DC; Wake Forest University School of Medicine, Winston-Salem, NC; Indiana University School of Medicine, Indianapolis, IN; and the University of Arizona College of Medicine and Arizona Cancer Center, Tucson, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark F.","family":"Brady","sequence":"additional","affiliation":[{"name":"From the Fox Chase Cancer Center, Philadelphia, PA; Roswell Park Cancer Institute, Buffalo, NY; University of California Los Angeles Medical Center, Los Angeles, CA, Mayo Comprehensive Cancer Center, Rochester, MN; Walter Reed Army Medical Center, Washington, DC; Wake Forest University School of Medicine, Winston-Salem, NC; Indiana University School of Medicine, Indianapolis, IN; and the University of Arizona College of Medicine and Arizona Cancer Center, Tucson, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta K.","family":"Nieberg","sequence":"additional","affiliation":[{"name":"From the Fox Chase Cancer Center, Philadelphia, PA; Roswell Park Cancer Institute, Buffalo, NY; University of California Los Angeles Medical Center, Los Angeles, CA, Mayo Comprehensive Cancer Center, Rochester, MN; Walter Reed Army Medical Center, Washington, DC; Wake Forest University School of Medicine, Winston-Salem, NC; Indiana University School of Medicine, Indianapolis, IN; and the University of Arizona College of Medicine and Arizona Cancer Center, Tucson, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry J.","family":"Long","sequence":"additional","affiliation":[{"name":"From the Fox Chase Cancer Center, Philadelphia, PA; Roswell Park Cancer Institute, Buffalo, NY; University of California Los Angeles Medical Center, Los Angeles, CA, Mayo Comprehensive Cancer Center, Rochester, MN; Walter Reed Army Medical Center, Washington, DC; Wake Forest University School of Medicine, Winston-Salem, NC; Indiana University School of Medicine, Indianapolis, IN; and the University of Arizona College of Medicine and Arizona Cancer Center, Tucson, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan R.","family":"Mayer","sequence":"additional","affiliation":[{"name":"From the Fox Chase Cancer Center, Philadelphia, PA; Roswell Park Cancer Institute, Buffalo, NY; University of California Los Angeles Medical Center, Los Angeles, CA, Mayo Comprehensive Cancer Center, Rochester, MN; Walter Reed Army Medical Center, Washington, DC; Wake Forest University School of Medicine, Winston-Salem, NC; Indiana University School of Medicine, Indianapolis, IN; and the University of Arizona College of Medicine and Arizona Cancer Center, Tucson, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Lentz","sequence":"additional","affiliation":[{"name":"From the Fox Chase Cancer Center, Philadelphia, PA; Roswell Park Cancer Institute, Buffalo, NY; University of California Los Angeles Medical Center, Los Angeles, CA, Mayo Comprehensive Cancer Center, Rochester, MN; Walter Reed Army Medical Center, Washington, DC; Wake Forest University School of Medicine, Winston-Salem, NC; Indiana University School of Medicine, Indianapolis, IN; and the University of Arizona College of Medicine and Arizona Cancer Center, Tucson, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Hurteau","sequence":"additional","affiliation":[{"name":"From the Fox Chase Cancer Center, Philadelphia, PA; Roswell Park Cancer Institute, Buffalo, NY; University of California Los Angeles Medical Center, Los Angeles, CA, Mayo Comprehensive Cancer Center, Rochester, MN; Walter Reed Army Medical Center, Washington, DC; Wake Forest University School of Medicine, Winston-Salem, NC; Indiana University School of Medicine, Indianapolis, IN; and the University of Arizona College of Medicine and Arizona Cancer Center, Tucson, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Alberts","sequence":"additional","affiliation":[{"name":"From the Fox Chase Cancer Center, Philadelphia, PA; Roswell Park Cancer Institute, Buffalo, NY; University of California Los Angeles Medical Center, Los Angeles, CA, Mayo Comprehensive Cancer Center, Rochester, MN; Walter Reed Army Medical Center, Washington, DC; Wake Forest University School of Medicine, Winston-Salem, NC; Indiana University School of Medicine, Indianapolis, IN; and the University of Arizona College of Medicine and Arizona Cancer Center, Tucson, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(86)90092-2"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199004123221501"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.8.1254"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(79)90950-5"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03590-X"},{"key":"R8","unstructured":"Dembo AJ: Radiotherapeutic management of ovarian cancer. Semin Oncol 11:238,1984\u2013250,"},{"key":"R9","unstructured":"Delclos L, Smith JP: Ovarian cancer: With special regard to types of radiotherapy. NCI Monogr 42:129,1975,"},{"key":"R10","unstructured":"Dembo AJ, Davy M, Stenwig AE, et al: Prognostic factors in patients with stage I epithelial ovarian cancer. Obstet Gynecol 75:263,1990\u2013273,"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197812)42:6<2563::AID-CNCR2820420609>3.0.CO;2-D"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90024-1"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.3109\/00016348509156735"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90083-P"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920201)69:3<741::AID-CNCR2820690322>3.0.CO;2-G"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a059355"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Cox DR: Regression model and life tables. J R Statistical Soc B 34:187,1972\u2013220,","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1993.10476289"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.2.105"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.2.125"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.2.113"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(84)90072-6"},{"key":"R24","unstructured":"Tammela J, Geisler JP, Eskew PNJ: Clear cell carcinoma of the ovary: Poor prognosis compared with serous carcinoma. Eur J Gynaecol Oncol 19:438,1998,"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199610000-00003"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1993.1117"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2003.02.154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T10:22:56Z","timestamp":1653819776000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2003.02.154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,1]]},"references-count":24,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2003,12,1]]}},"alternative-id":["10.1200\/JCO.2003.02.154"],"URL":"https:\/\/doi.org\/10.1200\/jco.2003.02.154","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,1]]}}}