{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:37:50Z","timestamp":1791729470953,"version":"4.3.4"},"reference-count":23,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2003,12,1]]},"abstract":"<jats:p> Purpose: Hyperuricemia and tumor lysis syndrome are well-known complications during induction treatment of aggressive non-Hodgkin\u2019s lymphomas (NHLs). Usual prophylaxis and treatment of hyperuricemia consist of hydration, alkalinization, and administration of allopurinol. This study was designed to evaluate the efficacy and the safety of rasburicase (recombinant urate oxidase) in adult patients with aggressive NHL during their first cycle of chemotherapy. <\/jats:p><jats:p> Patients and Methods: A total of 100 patients from Groupe d\u2019Etude des Lymphomes de l\u2019Adulte centers, with diffuse large B-cell lymphoma (n = 79); anaplastic large-cell lymphoma (n = 6); peripheral T-cell lymphoma (n = 8); transformation of indolent lymphoma (n = 5); Burkitt\u2019s lymphoma (n = 1); and lymphoblastic lymphoma (n = 1) were enrolled from May 2001 to June 2002. Before chemotherapy, 66% of patients had elevated lactate dehydrogenase (LDH), including 28% with LDH above 1,000 U\/mL. Eleven percent of patients were hyperuricemic (uric acid [UA] &gt; 450 mmol\/L or &gt; 7.56 mg\/dL). Rasburicase 0.20 mg\/kg\/d intravenously for 3 to 7 days was started the day before or at day 1 of chemotherapy. UA levels were measured 4 hours after rasburicase injection, then daily during treatment. <\/jats:p><jats:p> Results: All patients responded to rasburicase, as defined by normalization of UA levels maintained during chemotherapy. The control of UA was obtained within 4 hours after the first injection of the drug. Creatinine levels and other metabolites were also controlled with the administration of rasburicase. No patient exhibited increased creatinine levels or required dialysis during chemotherapy. <\/jats:p><jats:p> Conclusion: Rasburicase is the treatment of choice to control UA and prevent tumor lysis syndrome in adult patients with aggressive NHL. <\/jats:p>","DOI":"10.1200\/jco.2003.04.115","type":"journal-article","created":{"date-parts":[[2003,10,28]],"date-time":"2003-10-28T07:47:52Z","timestamp":1067327272000},"page":"4402-4406","source":"Crossref","is-referenced-by-count":188,"title":["Efficacy and Safety of Rasburicase (recombinant urate oxidase) for the Prevention and Treatment of Hyperuricemia During Induction Chemotherapy of Aggressive Non-Hodgkin\u2019s Lymphoma: Results of the GRAAL1 (Groupe d\u2019Etude des Lymphomes de l\u2019Adulte Trial on Rasburicase Activity in Adult Lymphoma) Study"],"prefix":"10.1200","volume":"21","author":[{"given":"Bertrand","family":"Coiffier","sequence":"first","affiliation":[{"name":"From the Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint-Louis, Paris; Centre Hospitalier Universitaire de Brabois, Vandoeuvre les Nancy; Institut Gustave Roussy, Villejuif; Centre Becquerel, Rouen; H\u00f4pital Bon Secours, Metz; Centre Hospitalier du Bocage, Dijon; Centre Hospitalier de N\u00eemes, N\u00eemes; H\u00f4pital Henri Mondor, Cr\u00e9teil; H\u00f4pital de Hautepierre, Strasbourg, France; and Universit\u00e9 Catholique de Louvain-Mont Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Mounier","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint-Louis, Paris; Centre Hospitalier Universitaire de Brabois, Vandoeuvre les Nancy; Institut Gustave Roussy, Villejuif; Centre Becquerel, Rouen; H\u00f4pital Bon Secours, Metz; Centre Hospitalier du Bocage, Dijon; Centre Hospitalier de N\u00eemes, N\u00eemes; H\u00f4pital Henri Mondor, Cr\u00e9teil; H\u00f4pital de Hautepierre, Strasbourg, France; and Universit\u00e9 Catholique de Louvain-Mont Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Bologna","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint-Louis, Paris; Centre Hospitalier Universitaire de Brabois, Vandoeuvre les Nancy; Institut Gustave Roussy, Villejuif; Centre Becquerel, Rouen; H\u00f4pital Bon Secours, Metz; Centre Hospitalier du Bocage, Dijon; Centre Hospitalier de N\u00eemes, N\u00eemes; H\u00f4pital Henri Mondor, Cr\u00e9teil; H\u00f4pital de Hautepierre, Strasbourg, France; and Universit\u00e9 Catholique de Louvain-Mont Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Ferm\u00e9","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint-Louis, Paris; Centre Hospitalier Universitaire de Brabois, Vandoeuvre les Nancy; Institut Gustave Roussy, Villejuif; Centre Becquerel, Rouen; H\u00f4pital Bon Secours, Metz; Centre Hospitalier du Bocage, Dijon; Centre Hospitalier de N\u00eemes, N\u00eemes; H\u00f4pital Henri Mondor, Cr\u00e9teil; H\u00f4pital de Hautepierre, Strasbourg, France; and Universit\u00e9 Catholique de Louvain-Mont Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Tilly","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint-Louis, Paris; Centre Hospitalier Universitaire de Brabois, Vandoeuvre les Nancy; Institut Gustave Roussy, Villejuif; Centre Becquerel, Rouen; H\u00f4pital Bon Secours, Metz; Centre Hospitalier du Bocage, Dijon; Centre Hospitalier de N\u00eemes, N\u00eemes; H\u00f4pital Henri Mondor, Cr\u00e9teil; H\u00f4pital de Hautepierre, Strasbourg, France; and Universit\u00e9 Catholique de Louvain-Mont Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Sonet","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint-Louis, Paris; Centre Hospitalier Universitaire de Brabois, Vandoeuvre les Nancy; Institut Gustave Roussy, Villejuif; Centre Becquerel, Rouen; H\u00f4pital Bon Secours, Metz; Centre Hospitalier du Bocage, Dijon; Centre Hospitalier de N\u00eemes, N\u00eemes; H\u00f4pital Henri Mondor, Cr\u00e9teil; H\u00f4pital de Hautepierre, Strasbourg, France; and Universit\u00e9 Catholique de Louvain-Mont Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Christian","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint-Louis, Paris; Centre Hospitalier Universitaire de Brabois, Vandoeuvre les Nancy; Institut Gustave Roussy, Villejuif; Centre Becquerel, Rouen; H\u00f4pital Bon Secours, Metz; Centre Hospitalier du Bocage, Dijon; Centre Hospitalier de N\u00eemes, N\u00eemes; H\u00f4pital Henri Mondor, Cr\u00e9teil; H\u00f4pital de Hautepierre, Strasbourg, France; and Universit\u00e9 Catholique de Louvain-Mont Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Casasnovas","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; 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