{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:16:55Z","timestamp":1790090215556,"version":"4.0.1"},"reference-count":25,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2003,8,1]]},"abstract":"<jats:p> Purpose: Damage to the CNS, including the cerebellum, and to the hypothalamopituitary axis, is documented in Langerhans cell histiocytosis (LCH). Neuropsychologic deficits have been recognized, but this is the first study in which cognitive function has been systematically assessed in a cohort of patients. <\/jats:p><jats:p> Patients and Methods: Twenty-eight long-term survivors of multisystem LCH (mean age, 15.1 years) were investigated for intelligence, memory and learning, language, and academic attainments. <\/jats:p><jats:p> Results: The mean intelligence quotient (IQ) of the entire group was not significantly different from the mean of the population (ie, mean \u00b1 SD, 100 \u00b1 1), but there were wide ranges (Full-Scale IQ [FSIQ]: mean, 93.6; range, 61.7 to 134; Performance IQ [PIQ]: mean, 92.2; range, 46 to 136; and Verbal IQ [VIQ]: mean, 93.7; range, 64.2 to 126). CNS involvement was a significant risk factor for lower scores, but sex, diabetes insipidus, and cranial radiotherapy were not. The CNS group had lower VIQ, PIQ, and FSIQ than patients with no CNS involvement (no CNS group: mean \u00b1 SD FSIQ, 102.3 \u00b1 15.6; CNS group: mean \u00b1 SD FSIQ, 73.6 \u00b1 7.7; P &lt; .001). A similar pattern of results was obtained for all other cognitive measures. Even when effects of reduction in FSIQ were taken into account, specific deficits were found in patients in the CNS group. <\/jats:p><jats:p> Conclusion: Long-term survivors of multisystem LCH, particularly patients with CNS involvement, may develop significant cognitive deficits. All patients should have formal, repeated neuropsychologic assessment as part of long-term follow-up, which will enable abnormalities to be detected early so that appropriate supportive measures can be offered. <\/jats:p>","DOI":"10.1200\/jco.2003.05.048","type":"journal-article","created":{"date-parts":[[2003,7,28]],"date-time":"2003-07-28T19:31:30Z","timestamp":1059420690000},"page":"2961-2967","source":"Crossref","is-referenced-by-count":54,"title":["Cognitive Outcome of Long-Term Survivors of Multisystem Langerhans Cell Histiocytosis: A Single-Institution, Cross-Sectional Study"],"prefix":"10.1200","volume":"21","author":[{"given":"Vasanta Rao","family":"Nanduri","sequence":"first","affiliation":[{"name":"From the Department of Haematology\/Oncology and Developmental Cognitive Neuroscience Unit, The Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom; and Department of Oncology and Haematology, Royal Hospital for Sick Children, Edinburgh, Scotland, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leasha","family":"Lillywhite","sequence":"additional","affiliation":[{"name":"From the Department of Haematology\/Oncology and Developmental Cognitive Neuroscience Unit, The Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom; and Department of Oncology and Haematology, Royal Hospital for Sick Children, Edinburgh, Scotland, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Chapman","sequence":"additional","affiliation":[{"name":"From the Department of Haematology\/Oncology and Developmental Cognitive Neuroscience Unit, The Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom; and Department of Oncology and Haematology, Royal Hospital for Sick Children, Edinburgh, Scotland, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Parry","sequence":"additional","affiliation":[{"name":"From the Department of Haematology\/Oncology and Developmental Cognitive Neuroscience Unit, The Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom; and Department of Oncology and Haematology, Royal Hospital for Sick Children, Edinburgh, Scotland, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Pritchard","sequence":"additional","affiliation":[{"name":"From the Department of Haematology\/Oncology and Developmental Cognitive Neuroscience Unit, The Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom; and Department of Oncology and Haematology, Royal Hospital for Sick Children, Edinburgh, Scotland, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraneh","family":"Vargha-Khadem","sequence":"additional","affiliation":[{"name":"From the Department of Haematology\/Oncology and Developmental Cognitive Neuroscience Unit, The Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom; and Department of Oncology and Haematology, Royal Hospital for Sick Children, Edinburgh, Scotland, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","unstructured":"Lichtenstein L: Histiocytosis X: Integration of eosinophilic granuloma of bone, \u201cLetterer-Siwe disease\u201d and \u201cSchuller-Christian disease\u201d as related manifestations of a single nosologic entity. 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