{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:24:57Z","timestamp":1783625097873,"version":"3.55.0"},"reference-count":56,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2003,7,15]]},"abstract":"<jats:p> Purpose: Intestinal non-Hodgkin\u2019s lymphomas are not well characterized. We therefore studied prospectively their clinical features and response to standardized therapy. <\/jats:p><jats:p> Patients and Methods: Fifty-six patients with primary intestinal lymphoma were included in a prospective, nonrandomized multicenter study. Lymphoma resection was recommended and staging was performed according to the Ann Arbor classification. Patients were scheduled to receive six cycles of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) chemotherapy, and at stages EIII to EIV, they received additional involved-field radiotherapy. Corticosteroids were used in patients who could not receive chemotherapy. <\/jats:p><jats:p> Results: Thirty-five patients had intestinal T-cell lymphoma (ITCL), 21 patients had intestinal B-cell lymphoma (IBCL; 18 diffuse large-cell lymphomas, two marginal-cell lymphomas, and one follicle-center lymphoma). Thirty-four patients at stages EI to EII (14 ITCL and 20 IBCL) and nine patients at stages EIII to EIV (all ITCL) received chemotherapy. No patient in stages EIII to EIV received radiotherapy, because death occurred in 12 of 14 patients. Two-year cumulative survival in patients with IBCL was 94% (95% CI, 82% to 100%) and higher than in patients with ITCL (28% [95% CI, 13% to 43%]; P &lt; .0001), even when only stages EI to EII were considered (ITCL, 37.5% [95% CI, 16.5% to 58.5%]; P &lt; .0001). IBCL patients compared with ITCL patients were at lower lymphoma stages (P &lt; .01), had higher Karnofsky status (P &lt; .005), had intestinal perforation less often (P &lt; .05), required emergency operation less often (P &lt; .05), received CHOP (P &lt; .05) more often, and reached complete remission (P &lt; .0005) more frequently. <\/jats:p><jats:p> Conclusion: IBCL patients at stages EI and EII respond well to chemotherapy, but the prognosis and treatment of ITCL patients is unsatisfactory. <\/jats:p>","DOI":"10.1200\/jco.2003.06.026","type":"journal-article","created":{"date-parts":[[2003,7,14]],"date-time":"2003-07-14T19:35:40Z","timestamp":1058211340000},"page":"2740-2746","source":"Crossref","is-referenced-by-count":205,"title":["Intestinal Non-Hodgkin\u2019s Lymphoma: A Multicenter Prospective Clinical Study From the German Study Group on Intestinal Non-Hodgkin\u2019s Lymphoma"],"prefix":"10.1200","volume":"21","author":[{"given":"Severin","family":"Daum","sequence":"first","affiliation":[{"name":"From the Department of Medicine I (Gastroenterology, Infectious Diseases and Rheumatology), the Institute of Pathology, the Department of Medicine II (Hematology, Oncology and Transfusion Medicine), Universit\u00e4tsklinikum Benjamin Franklin, Free University of Berlin; and the Medical Department, Auguste Viktoria-Krankenhaus, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Ullrich","sequence":"additional","affiliation":[{"name":"From the Department of Medicine I (Gastroenterology, Infectious Diseases and Rheumatology), the Institute of Pathology, the Department of Medicine II (Hematology, Oncology and Transfusion Medicine), Universit\u00e4tsklinikum Benjamin Franklin, Free University of Berlin; and the Medical Department, Auguste Viktoria-Krankenhaus, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Heise","sequence":"additional","affiliation":[{"name":"From the Department of Medicine I (Gastroenterology, Infectious Diseases and Rheumatology), the Institute of Pathology, the Department of Medicine II (Hematology, Oncology and Transfusion Medicine), Universit\u00e4tsklinikum Benjamin Franklin, Free University of Berlin; and the Medical Department, Auguste Viktoria-Krankenhaus, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Dederke","sequence":"additional","affiliation":[{"name":"From the Department of Medicine I (Gastroenterology, Infectious Diseases and Rheumatology), the Institute of Pathology, the Department of Medicine II (Hematology, Oncology and Transfusion Medicine), Universit\u00e4tsklinikum Benjamin Franklin, Free University of Berlin; and the Medical Department, Auguste Viktoria-Krankenhaus, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Dieter","family":"Foss","sequence":"additional","affiliation":[{"name":"From the Department of Medicine I (Gastroenterology, Infectious Diseases and Rheumatology), the Institute of Pathology, the Department of Medicine II (Hematology, Oncology and Transfusion Medicine), Universit\u00e4tsklinikum Benjamin Franklin, Free University of Berlin; and the Medical Department, Auguste Viktoria-Krankenhaus, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Stein","sequence":"additional","affiliation":[{"name":"From the Department of Medicine I (Gastroenterology, Infectious Diseases and Rheumatology), the Institute of Pathology, the Department of Medicine II (Hematology, Oncology and Transfusion Medicine), Universit\u00e4tsklinikum Benjamin Franklin, Free University of Berlin; and the Medical Department, Auguste Viktoria-Krankenhaus, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard","family":"Thiel","sequence":"additional","affiliation":[{"name":"From the Department of Medicine I (Gastroenterology, Infectious Diseases and Rheumatology), the Institute of Pathology, the Department of Medicine II (Hematology, Oncology and Transfusion Medicine), Universit\u00e4tsklinikum Benjamin Franklin, Free University of Berlin; 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