{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:41:37Z","timestamp":1773409297460,"version":"3.50.1"},"reference-count":25,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:p> Purpose: Regional lymph node status is the strongest prognostic determinant in early-stage melanoma. Lymphatic mapping and sentinel lymphadenectomy (LM\/SL) is standard to stage regional nodes because it is accurate and minimally morbid, yet its role for thin (\u2264 1.5 mm) primary melanomas is unknown. <\/jats:p><jats:p> Patients and Methods: Our melanoma database of more than 10,000 patients was reviewed for patients with melanomas \u2264 1.50 mm thick who underwent LM\/SL. All had lymphoscintigrams and LM\/SL via dye alone or with radiopharmaceutical. Patients with tumor-positive sentinel nodes (SNs) underwent completion dissections. <\/jats:p><jats:p> Results: Five hundred twelve patients underwent LM\/SL. Most were men (57%), and median age was 49 years. Most primary melanomas were on the torso (44%). Twenty-five patients (4.9%) had tumor-positive SNs. The thinnest lesion with a nodal metastasis was 0.35 mm. The SN-negative and SN-positive cohorts were equivalent by sex, but SN+ patients tended to be younger (P = .053), with significantly more SN metastases in those younger than 44 years (P = .005). No consistent pathology among SN-positive primary melanomas was found. Among those with 1.01- to 1.05-mm primaries, 7.1% were SN-positive. Among 272 patients with lesions \u2264 1.00 mm, 2.9% had positive SNs and 1.7% with lesions \u2264 0.75 mm had SN metastases. All 13 deaths were in SN-negative patients. Median follow-up durations in SN-positive and SN-negative patients were 25 and 45 months, respectively. <\/jats:p><jats:p> Conclusion: The high nodal positivity rate associated with primary melanomas 1.01 to 1.50 mm thick suggests that LM\/SL is indicated in this group. Younger age may be correlated with nodal metastases in patients with lesions \u2264 1.00 mm. Lesions \u2264 0.75 mm have minimal metastatic potential, and therefore LM\/SL is rarely indicated. <\/jats:p>","DOI":"10.1200\/jco.2003.06.123","type":"journal-article","created":{"date-parts":[[2003,3,27]],"date-time":"2003-03-27T19:03:23Z","timestamp":1048791803000},"page":"1326-1331","source":"Crossref","is-referenced-by-count":117,"title":["Role of Sentinel Lymphadenectomy in Thin Invasive Cutaneous Melanomas"],"prefix":"10.1200","volume":"21","author":[{"given":"Richard J.","family":"Bleicher","sequence":"first","affiliation":[{"name":"From the John Wayne Cancer Institute at Saint John\u2019s Health Center, Santa Monica, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Essner","sequence":"additional","affiliation":[{"name":"From the John Wayne Cancer Institute at Saint John\u2019s Health Center, Santa Monica, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leland J.","family":"Foshag","sequence":"additional","affiliation":[{"name":"From the John Wayne Cancer Institute at Saint John\u2019s Health Center, Santa Monica, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie A.","family":"Wanek","sequence":"additional","affiliation":[{"name":"From the John Wayne Cancer Institute at Saint John\u2019s Health Center, Santa Monica, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald L.","family":"Morton","sequence":"additional","affiliation":[{"name":"From the John Wayne Cancer Institute at Saint John\u2019s Health Center, Santa Monica, CA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199910000-00001"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-000-0262-z"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.3.976"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-999-0144-y"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.134.2.148"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1007\/s002689910078"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(99)00144-1"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.134.1.43"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.103028"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420040034005"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00533-X"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-59537-0_13"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2000.00005.x"},{"key":"R16","unstructured":"Riccioni L, Morigi F, Naldi S, et al: Anatomo-pathologic study of sentinel lymph nodes in melanoma: Analysis of 200 cases. 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