{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:47:37Z","timestamp":1762458457347},"reference-count":20,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"Purpose<\/jats:title> Correctly identifying infection in cancer patients can be challenging. Limited data suggest that positron emission tomography (PET) using fluorine-18 fluorodeoxyglucose (FDG) may be useful for diagnosing infection. To determine the role of FDG-PET in the diagnosis of infection in patients with multiple myeloma (MM). <\/jats:p><\/jats:sec>Patients and Methods<\/jats:title> The medical records of 248 patients who had FDG-PET performed for MM staging or infection work-up revealing increased uptake at extramedullary sites and\/or bones and joints that would be atypical for MM between October 2001 and May 2004 were reviewed to identify infections and evaluate FDG-PET contribution to patient outcome. <\/jats:p><\/jats:sec>Results<\/jats:title> One hundred sixty-five infections were identified in 143 adults with MM. Infections involved the respiratory tract [99; pneumonia (93), sinusitis (six)], bone, joint and soft tissues [26; discitis (10), osteomyelitis (nine), septic arthritis (one), cellulitis (six)], vascular system [18; septic thrombophlebitis (nine), infection of implantable catheter (eight), septic emboli (one)], gastrointestinal tract [12; colitis (seven), abdominal abscess (three), and diverticulitis and esophagitis (one each)], and dentition [periodontal abscess (10)]. Infections were caused by bacteria, mycobacteria, fungi, and viruses. FDG-PET detected infection even in patients with severe neutropenia and lymphopenia (30 episodes). The FDG-PET findings identified infections not detectable by other methods (46 episodes), determined extent of infection (32 episodes), and led to modification of work-up and therapy (55 episodes). Twenty silent, but clinically relevant, infections were detected among patients undergoing staging FDG-PET. <\/jats:p><\/jats:sec>Conclusion<\/jats:title> In patients with MM, FDG-PET is a useful tool for diagnosing and managing infections even in the setting of severe immunosuppression. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2004.00.8581","type":"journal-article","created":{"date-parts":[[2005,10,4]],"date-time":"2005-10-04T00:33:40Z","timestamp":1128386020000},"page":"7857-7863","source":"Crossref","is-referenced-by-count":107,"title":["18<\/sup>F-Fluorodeoxyglucose Positron Emission Tomography Contributes to the Diagnosis and Management of Infections in Patients With Multiple Myeloma: A Study of 165 Infectious Episodes"],"prefix":"10.1200","volume":"23","author":[{"given":"T.","family":"Mahfouz","sequence":"first","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.H.","family":"Miceli","sequence":"additional","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Saghafifar","sequence":"additional","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Stroud","sequence":"additional","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jones-Jackson","sequence":"additional","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Walker","sequence":"additional","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Grazziutti","sequence":"additional","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Purnell","sequence":"additional","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fassas","sequence":"additional","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Tricot","sequence":"additional","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Barlogie","sequence":"additional","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Anaissie","sequence":"additional","affiliation":[{"name":"From the University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, and the Department of Radiology, Little Rock, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"O\u2019Brien SN, Blijlevens NM, Mahfouz TH, et al: Infections in patients with hematological cancer: Recent developments. 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