{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:05:23Z","timestamp":1793833523011,"version":"4.6.1"},"reference-count":13,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2004,6,15]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To estimate the risk of contralateral breast cancer in BRCA1 and BRCA2 carriers after diagnosis and to determine which factors are predictive of the risk of a second primary breast cancer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients included 491 women with stage I or stage II breast cancer, for whom a BRCA1 or BRCA2 mutation had been identified in the family. Patients were followed from the initial diagnosis of cancer until contralateral mastectomy, contralateral breast cancer, death, or last follow-up. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The actuarial risk of contralateral breast cancer was 29.5% at 10 years. Factors that were predictive of a reduced risk were the presence of a BRCA2 mutation (v BRCA1 mutation; hazard ratio [HR], 0.73; 95% CI, 0.47 to 1.15); age 50 years or older at first diagnosis (v \u2264 49 years; HR, 0.63; 95% CI, 0.36 to 1.10); use of tamoxifen (HR, 0.59; 95% CI, 0.35 to 1.01); and history of oophorectomy (HR, 0.44; 95% CI, 0.21 to 0.91). The effect of oophorectomy was particularly strong in women first diagnosed prior to age 49 years (HR, 0.24; 95% CI, 0.07 to 0.77). For women who did not have an oophorectomy or take tamoxifen, the 10-year risk of contralateral cancer was 43.4% for BRCA1 carriers and 34.6% for BRCA2 carriers. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The risk of contralateral breast cancer in women with a BRCA mutation is approximately 40% at 10 years, and is reduced in women who take tamoxifen or who undergo an oophorectomy. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2004.04.033","type":"journal-article","created":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T18:03:07Z","timestamp":1087322587000},"page":"2328-2335","source":"Crossref","is-referenced-by-count":520,"title":["Contralateral Breast Cancer in <i>BRCA1<\/i> and <i>BRCA2<\/i> Mutation Carriers"],"prefix":"10.1200","volume":"22","author":[{"given":"Kelly","family":"Metcalfe","sequence":"first","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry T.","family":"Lynch","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parviz","family":"Ghadirian","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Tung","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Olivotto","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Warner","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunmilayo I.","family":"Olopade","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Eisen","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Weber","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"McLennan","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Foulkes","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Narod","sequence":"additional","affiliation":[{"name":"From the Faculty of Nursing and the Centre for Research on Women's Health, and Sunnybrook and Women's College Health Sciences Centre, University of Toronto; Toronto Sunnybrook Regional Cancer Centre, Toronto; Epidemiology Research Unit, Centre Hospitalier de Universit\u00e9 de Montreal (CHUM); Program in Cancer Genetics, McGill University, Montreal; British Columbia Cancer Agency, Vancouver; Hamilton Regional Cancer Centre, Hamilton, Canada; Department of Preventive Medicine and Public Health, Creighton..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1086\/301749"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07065-7"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.5.1642"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.19.3360"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.24.4045"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1239"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08434-9"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03258-X"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.17.1475"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012158"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.18.2251"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)05023-4"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Hoeijmakers JH: Genomic maintenance mechanisms for preventing cancer. 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