{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:58:35Z","timestamp":1761893915955},"reference-count":22,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2004,2,15]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To determine the relationship between the WHO and European Organization for Research and Treatment of Cancer (EORTC) pathologic classifications for primary cutaneous B-cell lymphoma (CBCL) and the implication of this relationship on initial treatment. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients with primary CBCL treated with radiotherapy were identified retrospectively. Initial biopsy specimens were reviewed by two dermatopathologists and classified according to the EORTC and WHO systems. Primary outcomes were recurrence-free and overall survival. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Thirty-four patients were identified; initial biopsy specimens were adequate for classification in 32 patients. Four different composite histopathologic subtypes of lymphoma were identified: 53% (17 of 32) follicle center cell by EORTC and diffuse large B-cell by WHO (FCC\/DLB), 25% (eight of 32) follicle center cell by EORTC and follicular by WHO (FCC\/Fol), 13% (four of 32) marginal zone by EORTC and WHO (MZ\/MZ), and 9% (three of 32) large B-cell of the leg by EORTC and diffuse large B-cell by WHO (Leg\/DLB). Five-year relapse-free survival ranged from 62% to 73% for FCC\/DLB, FCC\/Fol, and MZ\/MZ but was 33% for Leg\/DLB (P = .6). Five-year overall survival was 100% for FCC\/DLB, FCC\/Fol, and MZ\/MZ but was 67% for Leg\/DLB (P = .07). At 5 years, 21% of all patients had developed extracutaneous disease. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Two-thirds of primary cutaneous FCC lymphomas by EORTC criteria satisfy WHO criteria for DLB lymphoma. Unlike DLB lymphoma presenting in nodal or noncutaneous sites, these lesions are associated with an indolent course and may be treated with local radiotherapy alone. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2004.08.044","type":"journal-article","created":{"date-parts":[[2004,2,14]],"date-time":"2004-02-14T02:18:29Z","timestamp":1076725109000},"page":"634-639","source":"Crossref","is-referenced-by-count":63,"title":["Primary Cutaneous B-Cell Lymphoma Treated With Radiotherapy: A Comparison of the European Organization for Research and Treatment of Cancer and the WHO Classification Systems"],"prefix":"10.1200","volume":"22","author":[{"given":"Benjamin D.","family":"Smith","sequence":"first","affiliation":[{"name":"From the Departments of Therapeutic Radiology, Dermatology, and Internal Medicine, Section of Oncology, Yale University School of Medicine, New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Earl J.","family":"Glusac","sequence":"additional","affiliation":[{"name":"From the Departments of Therapeutic Radiology, Dermatology, and Internal Medicine, Section of Oncology, Yale University School of Medicine, New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"McNiff","sequence":"additional","affiliation":[{"name":"From the Departments of Therapeutic Radiology, Dermatology, and Internal Medicine, Section of Oncology, Yale University School of Medicine, New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace L.","family":"Smith","sequence":"additional","affiliation":[{"name":"From the Departments of Therapeutic Radiology, Dermatology, and Internal Medicine, Section of Oncology, Yale University School of Medicine, New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W.","family":"Heald","sequence":"additional","affiliation":[{"name":"From the Departments of Therapeutic Radiology, Dermatology, and Internal Medicine, Section of Oncology, Yale University School of Medicine, New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis L.","family":"Cooper","sequence":"additional","affiliation":[{"name":"From the Departments of Therapeutic Radiology, Dermatology, and Internal Medicine, Section of Oncology, Yale University School of Medicine, New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn D.","family":"Wilson","sequence":"additional","affiliation":[{"name":"From the Departments of Therapeutic Radiology, Dermatology, and Internal Medicine, Section of Oncology, Yale University School of Medicine, New Haven, CT"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.10.2152"},{"key":"R2","unstructured":"Willemze R, Kerl H, Sterry W, et al: EORTC classification for primary cutaneous lymphomas: A proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. 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