{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:40:26Z","timestamp":1762864826955},"reference-count":23,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2004,10,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Accumulating evidence shows that germline polymorphisms may affect survival in cancer. The purpose of this study was to investigate the association between polymorphisms in a group of candidate genes and survival with soft tissue sarcoma. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> We measured single nucleotide polymorphisms in the metabolizing, detoxifying, and DNA repair pathways in 120 newly diagnosed patients with soft tissue sarcoma. We assessed polymorphisms in the aryl hydrocarbon receptor (AhR-Arg554Lys), null variants of the glutathione S-transferase superfamily (GSTM1 and GSTT1), x-ray repair cross-complementing 1 and 3, and Xeroderma pigmentosum, group D (XRCC1-Arg399Gln, XRCC3-Thr241Met, XPD-Lys751Gln). We followed the patients for survival for a median of 7.6 years. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Cox proportional hazards models demonstrated that a polymorphism at codon 554 in exon 10 of the AhR was significantly and adversely associated with survival (hazard ratio, 2.2; 95% CI, 1.3 to 3.9; P &lt; .01), even while accounting for major clinical characteristics such as tumor grade, tumor size, anatomic site, and patient age. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Further study of the role of the AhR polymorphism is warranted. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2004.10.059","type":"journal-article","created":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T00:18:26Z","timestamp":1096503506000},"page":"3997-4001","source":"Crossref","is-referenced-by-count":22,"title":["Association Between Aryl Hydrocarbon Receptor Genotype and Survival in Soft Tissue Sarcoma"],"prefix":"10.1200","volume":"22","author":[{"given":"Marianne","family":"Berwick","sequence":"first","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center; Cornell University Medical School, New York, NY; Institute for Scientific Interchange; University of Turin, Turin, Italy; University of New Mexico, Albuquerque, NM; and Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Matullo","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center; Cornell University Medical School, New York, NY; Institute for Scientific Interchange; University of Turin, Turin, Italy; University of New Mexico, Albuquerque, NM; and Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan Shuang","family":"Song","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center; Cornell University Medical School, New York, NY; Institute for Scientific Interchange; University of Turin, Turin, Italy; University of New Mexico, Albuquerque, NM; and Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Guarrera","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center; Cornell University Medical School, New York, NY; Institute for Scientific Interchange; University of Turin, Turin, Italy; University of New Mexico, Albuquerque, NM; and Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Dominguez","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center; Cornell University Medical School, New York, NY; Institute for Scientific Interchange; University of Turin, Turin, Italy; University of New Mexico, Albuquerque, NM; and Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Orlow","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center; Cornell University Medical School, New York, NY; Institute for Scientific Interchange; University of Turin, Turin, Italy; University of New Mexico, Albuquerque, NM; and Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Walker","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center; Cornell University Medical School, New York, NY; Institute for Scientific Interchange; University of Turin, Turin, Italy; University of New Mexico, Albuquerque, NM; and Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Vineis","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center; Cornell University Medical School, New York, NY; Institute for Scientific Interchange; University of Turin, Turin, Italy; University of New Mexico, Albuquerque, NM; and Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.3109\/10409239509083491"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01290-6"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.12.936"},{"key":"R4","unstructured":"Krajinovic M, Labuda D, Mathonnet G, et al: Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia. 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