{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:55:29Z","timestamp":1778853329244,"version":"3.51.4"},"reference-count":35,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> A high percentage of early-stage, high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori dependent. t(11;18)(q21;q21), a genetic aberration highly predictive of H pylori\u2013independent status in low-grade gastric MALT lymphoma, is rarely detected in its high-grade counterpart. This study examined whether nuclear expression of BCL10 or nuclear factor kappa B (NF-\u03baB) is useful in predicting H pylori\u2013independent status in patients with stage IE high-grade gastric MALT lymphomas. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Twenty-two patients who had participated in a prospective study of H pylori eradication for stage IE high-grade gastric MALT lymphomas were studied. The expression of BCL10 and NF-\u03baB in pretreatment paraffin-embedded lymphoma tissues was evaluated by immunohistochemistry and confocal immunofluorescence microscopy. The presence of t(11;18)(q21;q21) was identified by a multiplex reverse transcriptase polymerase chain reaction of the API2-MALT1 chimeric transcript. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Aberrant nuclear expression of BCL10 was detected in seven (87.5%) of eight H pylori\u2013independent and in none of 14 H pylori\u2013dependent high-grade gastric MALT lymphomas (P &lt; .001). All seven patients with nuclear BCL10 expression had nuclear expression of NF-\u03baB, compared with only two of 15 patients without nuclear BCL10 expression (P = .002). As a single variable, the frequency of nuclear expression of NF-\u03baB was also significantly higher in H pylori\u2013independent tumors than in H pylori\u2013dependent tumors (seven of eight [87.5%] v two of 15 [12.3%]; P = .002). The API2-MALT1 fusion transcript was detected in only one (12.5%) of eight H pylori\u2013independent lymphomas. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Nuclear expression of BCL10 or NF-\u03baB is highly predictive of H pylori\u2013independent status in high-grade gastric MALT lymphoma, and coexpression of these two markers in the nuclei is frequent. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2004.10.087","type":"journal-article","created":{"date-parts":[[2004,8,30]],"date-time":"2004-08-30T22:33:03Z","timestamp":1093905183000},"page":"3491-3497","source":"Crossref","is-referenced-by-count":48,"title":["Nuclear Expression of BCL10 or Nuclear Factor Kappa B Predicts <i>Helicobacter pylori<\/i>\u2013Independent Status of Early-Stage, High-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphomas"],"prefix":"10.1200","volume":"22","author":[{"given":"Sung-Hsin","family":"Kuo","sequence":"first","affiliation":[{"name":"From the Departments of Oncology, Internal Medicine, and Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine; Cancer Research Center, Graduate Institute of Clinical Medicine, and Graduate Institute of Microbiology, National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institutes; Department of Pathology, Taipei Medical University, Taipei; and Department of Internal Medicine, Kaohsiung Medical University Hospital..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Tzong","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology, Internal Medicine, and Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine; Cancer Research Center, Graduate Institute of Clinical Medicine, and Graduate Institute of Microbiology, National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institutes; Department of Pathology, Taipei Medical University, Taipei; and Department of Internal Medicine, Kaohsiung Medical University Hospital..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun-Huei","family":"Yeh","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology, Internal Medicine, and Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine; Cancer Research Center, Graduate Institute of Clinical Medicine, and Graduate Institute of Microbiology, National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institutes; Department of Pathology, Taipei Medical University, Taipei; and Department of Internal Medicine, Kaohsiung Medical University Hospital..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Shiang","family":"Wu","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology, Internal Medicine, and Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine; Cancer Research Center, Graduate Institute of Clinical Medicine, and Graduate Institute of Microbiology, National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institutes; Department of Pathology, Taipei Medical University, Taipei; and Department of Internal Medicine, Kaohsiung Medical University Hospital..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Chen","family":"Hsu","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology, Internal Medicine, and Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine; Cancer Research Center, Graduate Institute of Clinical Medicine, and Graduate Institute of Microbiology, National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institutes; Department of Pathology, Taipei Medical University, Taipei; and Department of Internal Medicine, Kaohsiung Medical University Hospital..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Yen","family":"Yeh","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology, Internal Medicine, and Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine; Cancer Research Center, Graduate Institute of Clinical Medicine, and Graduate Institute of Microbiology, National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institutes; Department of Pathology, Taipei Medical University, Taipei; and Department of Internal Medicine, Kaohsiung Medical University Hospital..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsui-Lien","family":"Mao","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology, Internal Medicine, and Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine; 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