{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:16:24Z","timestamp":1780100184893,"version":"3.54.0"},"reference-count":36,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2004,7,15]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To define further the role of concurrent chemoradiotherapy for patients with advanced squamous carcinoma of the head and neck. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> The Radiation Therapy Oncology Group developed this three-arm randomized phase II trial. Patients with stage III or IV squamous carcinoma of the oral cavity, oropharynx, or hypopharynx were eligible. Each of three arms proposed a radiation schedule of 70 Gy in 35 fractions. Patients on arm 1 were to receive cisplatin 10 mg\/m<jats:sup>2<\/jats:sup> daily and fluorouracil (FU) 400 mg\/m<jats:sup>2<\/jats:sup> continuous infusion (CI) daily for the final 10 days of treatment. Treatment on arm 2 consisted of hydroxyurea 1 g every 12 hours and FU 800 mg\/m<jats:sup>2<\/jats:sup>\/d CI delivered with each fraction of radiation. Arm 3 patients were to receive weekly paclitaxel 30 mg\/m<jats:sup>2<\/jats:sup> and cisplatin 20 mg\/m<jats:sup>2<\/jats:sup>. Patients randomly assigned to arms 1 and 3 were to receive their treatments every week; patients on arm 2 were to receive their therapy every other week. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Between 1997 and 1999, 241 patients were entered onto study; 231 were analyzable. Ninety-two percent, 79%, and 83% of patients on arms 1, 2, and 3, respectively, were able to complete their radiation as planned or with an acceptable variation. Fewer than 10% of patients had unacceptable deviations or incomplete chemotherapy in the three arms. Estimated 2-year disease-free and overall survival rates were 38.2% and 57.4% for arm 1, 48.6% and 69.4% for arm 2, and 51.3% and 66.6% for arm 3. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> We have demonstrated that three different approaches of concurrent multiagent chemotherapy and radiation were feasible and could be delivered to patients in a multi-institutional setting with high compliance rates. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2004.12.012","type":"journal-article","created":{"date-parts":[[2004,7,14]],"date-time":"2004-07-14T22:35:28Z","timestamp":1089844528000},"page":"2856-2864","source":"Crossref","is-referenced-by-count":158,"title":["Preliminary Results of Radiation Therapy Oncology Group 97-03: A Randomized Phase II Trial of Concurrent Radiation and Chemotherapy for Advanced Squamous Cell Carcinomas of the Head and Neck"],"prefix":"10.1200","volume":"22","author":[{"given":"A.S.","family":"Garden","sequence":"first","affiliation":[{"name":"From The University of Texas M.D. Anderson Cancer Center, Houston, TX; 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