{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:58:38Z","timestamp":1791352718221,"version":"4.3.1"},"reference-count":16,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2004,6,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of malignancies characterized by a poor prognosis. We performed a pilot study to investigate the role of reduced-intensity conditioning (RIC) followed by allogeneic stem-cell transplantation in relapsed or refractory PTCLs. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> We have conducted a phase II trial on 17 patients receiving salvage chemotherapy followed by RIC and allogeneic transplantation of hematopoietic cells. The RIC regimen consisted of thiotepa, fludarabine, and cyclophosphamide. The acute graft-versus-host disease prophylaxis consisted of cyslosporine and short course methotrexate. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Patients had a median age of 41 years (range, 23 to 60 years). Two patients were primary chemorefractory, and 15 had relapsed disease; eight patients (47%) had a disease relapse after an autologous transplantation. After a median follow-up of 28 months from the day of study entry (range, 3 to 57 months), 14 of 17 patients were alive (12 in complete remission, one in partial remission, and one with stable disease), two died as a result of progressive disease, and one died as a result of sepsis concomitant to acute graft-versus-host disease. The estimated 3-year overall and progression-free survival rates were 81% (95% CI, 62% to 100%) and 64% (95% CI, 39% to 89%), respectively. The estimated probability of nonrelapse mortality at 2 years was 6% (95% CI, 1% to 17%). Donor lymphocyte infusions induced a response in two patients progressing after allografting. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> RIC followed by allogeneic stem-cell transplantation is feasible, has a low treatment-related mortality, and seems to be a promising salvage treatment for relapsed PTCL. These findings suggest that the existence of a graft-versus-T-cell lymphoma effect. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2004.12.050","type":"journal-article","created":{"date-parts":[[2004,5,28]],"date-time":"2004-05-28T23:08:15Z","timestamp":1085785695000},"page":"2172-2176","source":"Crossref","is-referenced-by-count":273,"title":["Graft-Versus-Lymphoma Effect in Relapsed Peripheral T-Cell Non-Hodgkin's Lymphomas After Reduced-Intensity Conditioning Followed by Allogeneic Transplantation of Hematopoietic Cells"],"prefix":"10.1200","volume":"22","author":[{"given":"Paolo","family":"Corradini","sequence":"first","affiliation":[{"name":"From the Divisions of Hematology and Medical Oncology, Istituto Nazionale Tumori, University of Milano, and the Department of Hematology, H.S. Raffaele, Milan; the Department of Hematology, University of Torino, Torino; the Department of Hematology, Ospedale Regionale, Bolzano; the Department of Hematology, University of Modena, Modena; the Department of Hematology, University of Udine, Udine; the Department of Hematology, University of Verona, Verona; and the Department of Hematology, Ospedali Riuniti..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Dodero","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology and Medical Oncology, Istituto Nazionale Tumori, University of Milano, and the Department of Hematology, H.S. Raffaele, Milan; the Department of Hematology, University of Torino, Torino; the Department of Hematology, Ospedale Regionale, Bolzano; the Department of Hematology, University of Modena, Modena; the Department of Hematology, University of Udine, Udine; the Department of Hematology, University of Verona, Verona; and the Department of Hematology, Ospedali Riuniti..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Zallio","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology and Medical Oncology, Istituto Nazionale Tumori, University of Milano, and the Department of Hematology, H.S. Raffaele, Milan; the Department of Hematology, University of Torino, Torino; the Department of Hematology, Ospedale Regionale, Bolzano; the Department of Hematology, University of Modena, Modena; the Department of Hematology, University of Udine, Udine; the Department of Hematology, University of Verona, Verona; and the Department of Hematology, Ospedali Riuniti..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Caracciolo","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology and Medical Oncology, Istituto Nazionale Tumori, University of Milano, and the Department of Hematology, H.S. Raffaele, Milan; the Department of Hematology, University of Torino, Torino; the Department of Hematology, Ospedale Regionale, Bolzano; the Department of Hematology, University of Modena, Modena; the Department of Hematology, University of Udine, Udine; the Department of Hematology, University of Verona, Verona; and the Department of Hematology, Ospedali Riuniti..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Casini","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology and Medical Oncology, Istituto Nazionale Tumori, University of Milano, and the Department of Hematology, H.S. Raffaele, Milan; the Department of Hematology, University of Torino, Torino; the Department of Hematology, Ospedale Regionale, Bolzano; the Department of Hematology, University of Modena, Modena; the Department of Hematology, University of Udine, Udine; the Department of Hematology, University of Verona, Verona; and the Department of Hematology, Ospedali Riuniti..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bregni","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology and Medical Oncology, Istituto Nazionale Tumori, University of Milano, and the Department of Hematology, H.S. Raffaele, Milan; the Department of Hematology, University of Torino, Torino; the Department of Hematology, Ospedale Regionale, Bolzano; the Department of Hematology, University of Modena, Modena; the Department of Hematology, University of Udine, Udine; the Department of Hematology, University of Verona, Verona; and the Department of Hematology, Ospedali Riuniti..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Narni","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology and Medical Oncology, Istituto Nazionale Tumori, University of Milano, and the Department of Hematology, H.S. Raffaele, Milan; the Department of Hematology, University of Torino, Torino; the Department of Hematology, Ospedale Regionale, Bolzano; the Department of Hematology, University of Modena, Modena; the Department of Hematology, University of Udine, Udine; the Department of Hematology, University of Verona, Verona; and the Department of Hematology, Ospedali Riuniti..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Patriarca","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology and Medical Oncology, Istituto Nazionale Tumori, University of Milano, and the Department of Hematology, H.S. Raffaele, Milan; the Department of Hematology, University of Torino, Torino; the Department of Hematology, Ospedale Regionale, Bolzano; the Department of Hematology, University of Modena, Modena; the Department of Hematology, University of Udine, Udine; the Department of Hematology, University of Verona, Verona; and the Department of Hematology, Ospedali Riuniti..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Boccadoro","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology and Medical Oncology, Istituto Nazionale Tumori, University of Milano, and the Department of Hematology, H.S. Raffaele, Milan; the Department of Hematology, University of Torino, Torino; the Department of Hematology, Ospedale Regionale, Bolzano; the Department of Hematology, University of Modena, Modena; the Department of Hematology, University of Udine, Udine; the Department of Hematology, University of Verona, Verona; and the Department of Hematology, Ospedali Riuniti..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Benedetti","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology and Medical Oncology, Istituto Nazionale Tumori, University of Milano, and the Department of Hematology, H.S. 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