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Treatment of NM utilizes involved-field radiotherapy of bulky or symptomatic disease sites and intra-CSF drug therapy. The inclusion of concomitant systemic therapy may benefit patients with NM and may obviate the need for intra-CSF chemotherapy. At present, intra-CSF drug therapy is confined to three chemotherapeutic agents (ie, methotrexate, cytarabine, and thiotepa) administered by a variety of schedules either by intralumbar or intraventricular drug delivery. Although treatment of NM is palliative with an expected median patient survival of 2 to 6 months, it often affords stabilization and protection from further neurologic deterioration in patients with NM. <\/jats:p>","DOI":"10.1200\/jco.2005.01.131","type":"journal-article","created":{"date-parts":[[2005,5,20]],"date-time":"2005-05-20T23:31:45Z","timestamp":1116631905000},"page":"3605-3613","source":"Crossref","is-referenced-by-count":110,"title":["Neoplastic Meningitis"],"prefix":"10.1200","volume":"23","author":[{"given":"Marc C.","family":"Chamberlain","sequence":"first","affiliation":[{"name":"From the Department of Interdisciplinary Oncology, University of S Florida, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","unstructured":"Shapiro WR, Posner JB, Ushio Y, et al: Treatment of meningeal neoplasms. 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