{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:49:54Z","timestamp":1763016594060},"reference-count":44,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"30","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,10,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> We analyzed the impact of allogeneic stem-cell transplantation (alloSCT) as an early consolidation for young patients with acute myeloblastic leukemia in first complete remission (CR1) through four successive protocols. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Of the 472 patients who achieved CR1, 182 (38%) had an HLA-identical sibling (donor group), and alloSCT was performed in 171 patients (94%). Of the 290 patients without donor (no-donor group), 62% received an autologous SCT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> In an intent-to-treat analysis based on donor availability, the overall 10-year survival probability was 51% v 43% (P = .11) for the donor and no-donor groups, respectively. A Cox analysis determined that four factors had independent prognostic significance for survival (initial WBC count, French-American-British subtypes, cytogenetic risk, and number of induction courses). This permitted constitution of a simple index that reclassified 21% of the patients compared with usual cytogenetic classification and identified three subpopulations with different outcome and different impact of alloSCT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> AlloSCT was associated with a survival advantage for an intermediate-risk group. In other groups, numbers are limited for definitive conclusion. However, early performed alloSCT does not seem to be the optimal treatment of high-risk patients or offer any advantage over intensive chemotherapy in low-risk patients. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.02.5940","type":"journal-article","created":{"date-parts":[[2005,9,27]],"date-time":"2005-09-27T00:44:00Z","timestamp":1127781840000},"page":"7676-7684","source":"Crossref","is-referenced-by-count":51,"title":["Early Allogeneic Stem-Cell Transplantation for Young Adults With Acute Myeloblastic Leukemia in First Complete Remission: An Intent-to-Treat Long-Term Analysis of the BGMT Experience"],"prefix":"10.1200","volume":"23","author":[{"given":"Eric","family":"Jourdan","sequence":"first","affiliation":[{"name":"From the D\u00e9partement d'H\u00e9matologie, H\u00f4pital Caremeau, Centre Hospitalier Universitaire (CHU), N\u00eemes; D\u00e9partement d'H\u00e9matologie, H\u00f4pital Haut-Lev\u00eaque, CHU, Bordeaux; Unit\u00e9 de Cytog\u00e9n\u00e9tique and D\u00e9partement d'H\u00e9matologie, H\u00f4pital Purpan, CHU, Toulouse; D\u00e9partement d'H\u00e9matologie and Unit\u00e9 de Biostatistiques, Institut Paoli Calmettes, Marseille; D\u00e9partement d'H\u00e9matologie, H\u00f4pital Michalon, CHU, Grenoble; and D\u00e9partement d'H\u00e9matologie, H\u00f4pital Lapeyronie, CHU, Montpellier, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Michel","family":"Boiron","sequence":"additional","affiliation":[{"name":"From the D\u00e9partement d'H\u00e9matologie, H\u00f4pital Caremeau, Centre Hospitalier Universitaire (CHU), N\u00eemes; D\u00e9partement d'H\u00e9matologie, H\u00f4pital Haut-Lev\u00eaque, CHU, Bordeaux; Unit\u00e9 de Cytog\u00e9n\u00e9tique and D\u00e9partement d'H\u00e9matologie, H\u00f4pital Purpan, CHU, Toulouse; D\u00e9partement d'H\u00e9matologie and Unit\u00e9 de Biostatistiques, Institut Paoli Calmettes, Marseille; D\u00e9partement d'H\u00e9matologie, H\u00f4pital Michalon, CHU, Grenoble; and D\u00e9partement d'H\u00e9matologie, H\u00f4pital Lapeyronie, CHU, Montpellier, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Dastugue","sequence":"additional","affiliation":[{"name":"From the D\u00e9partement d'H\u00e9matologie, H\u00f4pital Caremeau, Centre Hospitalier Universitaire (CHU), N\u00eemes; D\u00e9partement d'H\u00e9matologie, H\u00f4pital Haut-Lev\u00eaque, CHU, Bordeaux; Unit\u00e9 de Cytog\u00e9n\u00e9tique and D\u00e9partement d'H\u00e9matologie, H\u00f4pital Purpan, CHU, Toulouse; D\u00e9partement d'H\u00e9matologie and Unit\u00e9 de Biostatistiques, Institut Paoli Calmettes, Marseille; D\u00e9partement d'H\u00e9matologie, H\u00f4pital Michalon, CHU, Grenoble; and D\u00e9partement d'H\u00e9matologie, H\u00f4pital Lapeyronie, CHU, Montpellier, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Vey","sequence":"additional","affiliation":[{"name":"From the D\u00e9partement d'H\u00e9matologie, H\u00f4pital Caremeau, Centre Hospitalier Universitaire (CHU), N\u00eemes; D\u00e9partement d'H\u00e9matologie, H\u00f4pital Haut-Lev\u00eaque, CHU, Bordeaux; Unit\u00e9 de Cytog\u00e9n\u00e9tique and D\u00e9partement d'H\u00e9matologie, H\u00f4pital Purpan, CHU, Toulouse; D\u00e9partement d'H\u00e9matologie and Unit\u00e9 de Biostatistiques, Institut Paoli Calmettes, Marseille; D\u00e9partement d'H\u00e9matologie, H\u00f4pital Michalon, CHU, Grenoble; and D\u00e9partement d'H\u00e9matologie, H\u00f4pital Lapeyronie, CHU, Montpellier, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rald","family":"Marit","sequence":"additional","affiliation":[{"name":"From the D\u00e9partement d'H\u00e9matologie, H\u00f4pital Caremeau, Centre Hospitalier Universitaire (CHU), N\u00eemes; D\u00e9partement d'H\u00e9matologie, H\u00f4pital Haut-Lev\u00eaque, CHU, Bordeaux; Unit\u00e9 de Cytog\u00e9n\u00e9tique and D\u00e9partement d'H\u00e9matologie, H\u00f4pital Purpan, CHU, Toulouse; D\u00e9partement d'H\u00e9matologie and Unit\u00e9 de Biostatistiques, Institut Paoli Calmettes, Marseille; D\u00e9partement d'H\u00e9matologie, H\u00f4pital Michalon, CHU, Grenoble; and D\u00e9partement d'H\u00e9matologie, H\u00f4pital Lapeyronie, CHU, Montpellier, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Rigal-Huguet","sequence":"additional","affiliation":[{"name":"From the D\u00e9partement d'H\u00e9matologie, H\u00f4pital Caremeau, Centre Hospitalier Universitaire (CHU), N\u00eemes; 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