{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:32:26Z","timestamp":1772166746400,"version":"3.50.1"},"reference-count":39,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2006,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the incidence of and risk factors for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in survivors of hematopoietic cell transplantation (HCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The impact of patient-, disease-, treatment-, and toxicity-related factors on risk of BCC and SCC was determined in a retrospective cohort study of 4,810 patients who received allogeneic HCT and who survived for at least 100 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among allogeneic HCT recipients, 237 developed at least one skin or mucosal cancer (BCC, n = 158; SCC, n = 95). Twenty-year cumulative incidences of BCC and SCC were 6.5% and 3.4%, respectively. Total-body irradiation was a significant risk factor for BCC (P = .003), most strongly among patients younger than 18 years old at HCT (P = .02, interaction). Light-skinned patients had an increased risk of BCC (P = .01). Acute graft-versus-host disease (GVHD) increased the risk of SCC (P = .02), whereas chronic GVHD increased the risk of both BCC (P = .01) and SCC (P &lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This analysis suggests that immutable factors, such as age and complexion, have a significant impact on BCC and SCC. However, specific treatment (radiotherapy) and transplantation complications (GVHD) may modify that risk. These additional risk factors suggest the contribution of immunologic mechanism DNA and tissue repair in the development of BCC and SCC. We confirm previous reports that exposure to ionizing radiation increases the risk of BCC but not SCC. Survivors of HCT should be monitored for the development of BCC and SCC and use preventive strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2005.02.7052","type":"journal-article","created":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T20:32:40Z","timestamp":1139257960000},"page":"1119-1126","source":"Crossref","is-referenced-by-count":170,"title":["Nonmelanoma Skin and Mucosal Cancers After Hematopoietic Cell Transplantation"],"prefix":"10.1200","volume":"24","author":[{"given":"Wendy","family":"Leisenring","sequence":"first","affiliation":[{"name":"From the Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra L.","family":"Friedman","sequence":"additional","affiliation":[{"name":"From the Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.D.","family":"Flowers","sequence":"additional","affiliation":[{"name":"From the Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey L.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"From the Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Joachim","family":"Deeg","sequence":"additional","affiliation":[{"name":"From the Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199703273361301"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.2.348"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603213341201"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Flowers MED, Deeg HJ: Delayed complications after hematopoietic cell transplantation, in Blume KG, Forman SJ, Appelbaum FR (eds): Thomas' Hematopoietic Cell Transplantation (ed 3) . Oxford, United Kingdom, Blackwell Publishing Ltd, pp,2004 944-961","DOI":"10.1002\/9780470987070.ch69"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb04325.x"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.9.3634.bloodjournal8893634"},{"key":"R7","unstructured":"Sullivan KM: Graft-versus-host disease, in Thomas ED, Blume KG, Forman SJ (eds): Hematopoietic Cell Transplantation (ed 2) . Malden, MA, Blackwell Sciences, Inc, pp,1999 515-536"},{"key":"R8","unstructured":"Benesch M, Deeg HJ: Acute graft-versus-host disease, in Atkinson MK, Champlin R, Ritz J, et al (eds): Clinical Bone Marrow and Blood Stem Cell Transplantation (ed 3) . Cambridge, United Kingdom, Cambridge University Press, pp,2004 1109-1132"},{"key":"R9","unstructured":"Kalbfleisch JD, Prentice RL: The Statistical Analysis of Failure Time Data . New York, NY, John Wiley & Sons, 1980"},{"key":"R10","unstructured":"Marubini E, Valsecchi MG: Analyzing Survival Data from Clinical Trials and Observational Studies . Chichester, NY, John Wiley and Sons, 1995"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg278"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.2307\/3577012"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.24.1848"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.8.1007"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-199507000-00009"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.2307\/3578117"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008867617415"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1080\/09553009014550951"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81190-5"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2002)157[0410:SCAXRT]2.0.CO;2"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(01)00198-1"},{"key":"R24","unstructured":"Gallagher RP, Bajdik CD, Fincham S, et al: Chemical exposures, medical history, and risk of squamous and basal cell carcinoma of the skin. Cancer Epidemiol Biomarkers Prev 5:419,1996-424,"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3411"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1033"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200108270-00024"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206989"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-10-199911160-00004"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.8.618"},{"key":"R32","unstructured":"Tucker MA, Jones PH, Boice JD Jr, et al: Therapeutic radiation at a young age is linked to secondary thyroid cancer: The Late Effects Study Group. Cancer Res 51:2885,1991-2888,"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990517)81:4<555::AID-IJC9>3.0.CO;2-R"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.6.1833"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.03178"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.108"},{"key":"R37","doi-asserted-by":"crossref","unstructured":"Bhatia S, Bhatia R: Secondary malignancies after hematopoietic cell transplantation, in Blume KG, Forman SJ, Appelbaum FR (eds): Thomas' Hematopoietic Cell Transplantation (ed 3) . Malden, MA, Blackwell Publishing Ltd, pp,2004 962-977","DOI":"10.1002\/9780470987070.ch70"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.9.3633.bloodjournal8793633"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022137"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199809150-00023"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.237"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2005.02.7052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T17:02:27Z","timestamp":1653498147000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2005.02.7052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,1]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,3,1]]}},"alternative-id":["10.1200\/JCO.2005.02.7052"],"URL":"https:\/\/doi.org\/10.1200\/jco.2005.02.7052","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11459.468944","asserted-by":"object"}]},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,1]]}}}