{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:13:07Z","timestamp":1777619587871,"version":"3.51.4"},"reference-count":40,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,9,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Sezary syndrome (SS) and tumor-stage mycosis fungoides (MF) are generally incurable with currently available treatments. We conducted a retrospective study to evaluate the outcome of allogeneic hematopoietic stem-cell transplantation (HSCT) in this patient population. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patient and Methods<\/jats:title><jats:p> From August 1996 through October 2002, eight patients with advanced MF\/SS underwent allogeneic HSCT at our institution. All patients were heavily pretreated, having failed a median number of seven prior therapies (range, five to 12). Clonal T-cell populations in peripheral blood or bone marrow were detectable by polymerase chain reaction analyses of T-cell receptor \u03b3-chain gene rearrangements in six patients and cytogenetics in three patients. The conditioning regimen included total-body irradiation and cyclophosphamide (n = 3), busulfan and cyclophosphamide (n = 1), and the reduced-intensity regimen of fludarabine and melphalan (n = 4). Allogeneic hematopoietic stem cells were obtained from HLA-matched siblings (n = 4) and unrelated donors (n = 4). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> All patients achieved complete clinical remission and resolution of molecular and cytogenetic markers of disease within 30 to 60 days after HSCT. Two patients died from transplantation-related complications; graft-versus-host disease (GVHD; n = 1) and respiratory syncytial virus pneumonia (n = 1). With a median follow-up of 56 months, six patients remain alive and without evidence of lymphoma. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Our results suggest that allogeneic HSCT from both HLA\u2013matched sibling and unrelated donors can induce durable clinical, molecular, and cytogenetic remissions in patients with advanced cutaneous T-cell lymphoma that is refractory to standard therapies. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.02.774","type":"journal-article","created":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T03:31:37Z","timestamp":1125459097000},"page":"6163-6171","source":"Crossref","is-referenced-by-count":113,"title":["Durable Clinical, Cytogenetic, and Molecular Remissions After Allogeneic Hematopoietic Cell Transplantation for Refractory Sezary Syndrome and Mycosis Fungoides"],"prefix":"10.1200","volume":"23","author":[{"given":"Arturo","family":"Molina","sequence":"first","affiliation":[{"name":"From the Divisions of Hematology\/Hematopoietic Cell Transplantation and Anatomic Pathology (Hematopathology and Cytogenetics), City of Hope National Medical Center, Duarte, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Zain","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology\/Hematopoietic Cell Transplantation and Anatomic Pathology (Hematopathology and Cytogenetics), City of Hope National Medical Center, Duarte, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Arber","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology\/Hematopoietic Cell Transplantation and Anatomic Pathology (Hematopathology and Cytogenetics), City of Hope National Medical Center, Duarte, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Angelopolou","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology\/Hematopoietic Cell Transplantation and Anatomic Pathology (Hematopathology and Cytogenetics), City of Hope National Medical Center, Duarte, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology\/Hematopoietic Cell Transplantation and Anatomic Pathology (Hematopathology and Cytogenetics), City of Hope National Medical Center, Duarte, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Murata-Collins","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology\/Hematopoietic Cell Transplantation and Anatomic Pathology (Hematopathology and Cytogenetics), City of Hope National Medical Center, Duarte, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Forman","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology\/Hematopoietic Cell Transplantation and Anatomic Pathology (Hematopathology and Cytogenetics), City of Hope National Medical Center, Duarte, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Auayporn","family":"Nademanee","sequence":"additional","affiliation":[{"name":"From the Divisions of Hematology\/Hematopoietic Cell Transplantation and Anatomic Pathology (Hematopathology and Cytogenetics), City of Hope National Medical Center, Duarte, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.7.2385.bloodjournal8872385"},{"key":"R2","unstructured":"Kim YH, Hoppe RT: Mycosis fungoides and the Sezary syndrome. 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