{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:23:51Z","timestamp":1784967831991,"version":"3.55.0"},"reference-count":20,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,3,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To determine the feasibility of high-dose intra-arterial (IA) cisplatin and concurrent radiation therapy (RT) for head and neck squamous cell carcinoma in the multi-institutional setting (Multi-RADPLAT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Eligibility included T4 squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx. Patients received cisplatin (150 mg\/m<jats:sup>2<\/jats:sup> IA with sodium thiosulfate 9 g\/m<jats:sup>2<\/jats:sup> intravenous [IV], followed by 12 g\/m<jats:sup>2<\/jats:sup> IV over 6 hours, weekly for 4 weeks) and concurrent RT (70 Gy, 2.0 Gy\/fraction, daily for 5 days over 7 weeks). Between May 1997 and December 1999, 67 patients from three experienced and eight inexperienced centers were enrolled, of whom 61 were eligible for analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Multi-RADPLAT was feasible (ie, three or four infusions of IA cisplatin and full dose of RT) in 53 patients (87%). The complete response (CR) rate was 85% at the primary site and 88% at nodal regions, and the overall CR rate was 80%. At a median follow-up of 3.9 years for alive patients (range, 0.9 to 6.1 years), the estimated 1-year and 2-year locoregional tumor control rates are 66% and 57%, respectively. The estimated 1-year and 2-year survival rates are 72% and 63%, respectively. The estimated 1-year and 2-year disease-free survival rates are 62% and 46%, respectively. The rates of grade 4 and 5 toxicities at the experienced and the inexperienced institutions were 14% and 0% v 47% and 4%, respectively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> This intensive treatment regimen for head and neck cancer is feasible and effective in a multi-institutional setting. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.03.168","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T00:11:44Z","timestamp":1109376704000},"page":"1447-1454","source":"Crossref","is-referenced-by-count":116,"title":["Supradose Intra-Arterial Cisplatin and Concurrent Radiation Therapy for the Treatment of Stage IV Head and Neck Squamous Cell Carcinoma Is Feasible and Efficacious in a Multi-Institutional Setting: Results of Radiation Therapy Oncology Group Trial 9615"],"prefix":"10.1200","volume":"23","author":[{"given":"K. Thomas","family":"Robbins","sequence":"first","affiliation":[{"name":"From the Southern Illinois University School of Medicine, Springfield, IL; University of Southern California, Keck School of Medicine, Los Angeles; University of California San Diego, San Diego; University of California San Francisco, San Francisco, CA; Radiation Therapy Oncology Group, Philadelphia, PA; University of Iowa, Iowa City, IA; Vanderbilt University Medical Center, Nashville, TN; University of Vermont, Burlington, VT; University of Virginia, Charlottesville, VA; The George Washington..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"From the Southern Illinois University School of Medicine, Springfield, IL; University of Southern California, Keck School of Medicine, Los Angeles; University of California San Diego, San Diego; University of California San Francisco, San Francisco, CA; Radiation Therapy Oncology Group, Philadelphia, PA; University of Iowa, Iowa City, IA; Vanderbilt University Medical Center, Nashville, TN; University of Vermont, Burlington, VT; University of Virginia, Charlottesville, VA; The George Washington..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Harris","sequence":"additional","affiliation":[{"name":"From the Southern Illinois University School of Medicine, Springfield, IL; University of Southern California, Keck School of Medicine, Los Angeles; University of California San Diego, San Diego; University of California San Francisco, San Francisco, CA; Radiation Therapy Oncology Group, Philadelphia, PA; University of Iowa, Iowa City, IA; Vanderbilt University Medical Center, Nashville, TN; University of Vermont, Burlington, VT; University of Virginia, Charlottesville, VA; The George Washington..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"McCulloch","sequence":"additional","affiliation":[{"name":"From the Southern Illinois University School of Medicine, Springfield, IL; University of Southern California, Keck School of Medicine, Los Angeles; University of California San Diego, San Diego; University of California San Francisco, San Francisco, CA; Radiation Therapy Oncology Group, Philadelphia, PA; University of Iowa, Iowa City, IA; Vanderbilt University Medical Center, Nashville, TN; University of Vermont, Burlington, VT; University of Virginia, Charlottesville, VA; The George Washington..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Cmelak","sequence":"additional","affiliation":[{"name":"From the Southern Illinois University School of Medicine, Springfield, IL; University of Southern California, Keck School of Medicine, Los Angeles; University of California San Diego, San Diego; University of California San Francisco, San Francisco, CA; Radiation Therapy Oncology Group, Philadelphia, PA; University of Iowa, Iowa City, IA; Vanderbilt University Medical Center, Nashville, TN; University of Vermont, Burlington, VT; University of Virginia, Charlottesville, VA; The George Washington..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sofferman","sequence":"additional","affiliation":[{"name":"From the Southern Illinois University School of Medicine, Springfield, IL; University of Southern California, Keck School of Medicine, Los Angeles; University of California San Diego, San Diego; University of California San Francisco, San Francisco, CA; Radiation Therapy Oncology Group, Philadelphia, PA; University of Iowa, Iowa City, IA; Vanderbilt University Medical Center, Nashville, TN; University of Vermont, Burlington, VT; University of Virginia, Charlottesville, VA; The George Washington..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Levine","sequence":"additional","affiliation":[{"name":"From the Southern Illinois University School of Medicine, Springfield, IL; University of Southern California, Keck School of Medicine, Los Angeles; University of California San Diego, San Diego; University of California San Francisco, San Francisco, CA; Radiation Therapy Oncology Group, Philadelphia, PA; University of Iowa, Iowa City, IA; Vanderbilt University Medical Center, Nashville, TN; University of Vermont, Burlington, VT; University of Virginia, Charlottesville, VA; The George Washington..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Weisman","sequence":"additional","affiliation":[{"name":"From the Southern Illinois University School of Medicine, Springfield, IL; University of Southern California, Keck School of Medicine, Los Angeles; University of California San Diego, San Diego; University of California San Francisco, San Francisco, CA; Radiation Therapy Oncology Group, Philadelphia, PA; University of Iowa, Iowa City, IA; Vanderbilt University Medical Center, Nashville, TN; University of Vermont, Burlington, VT; University of Virginia, Charlottesville, VA; The George Washington..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wilson","sequence":"additional","affiliation":[{"name":"From the Southern Illinois University School of Medicine, Springfield, IL; University of Southern California, Keck School of Medicine, Los Angeles; University of California San Diego, San Diego; University of California San Francisco, San Francisco, CA; Radiation Therapy Oncology Group, Philadelphia, PA; University of Iowa, Iowa City, IA; Vanderbilt University Medical Center, Nashville, TN; University of Vermont, Burlington, VT; University of Virginia, Charlottesville, VA; The George Washington..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Weymuller","sequence":"additional","affiliation":[{"name":"From the Southern Illinois University School of Medicine, Springfield, IL; University of Southern California, Keck School of Medicine, Los Angeles; University of California San Diego, San Diego; University of California San Francisco, San Francisco, CA; Radiation Therapy Oncology Group, Philadelphia, PA; University of Iowa, Iowa City, IA; Vanderbilt University Medical Center, Nashville, TN; University of Vermont, Burlington, VT; University of Virginia, Charlottesville, VA; The George Washington..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Fu","sequence":"additional","affiliation":[{"name":"From the Southern Illinois University School of Medicine, Springfield, IL; University of Southern California, Keck School of Medicine, Los Angeles; University of California San Diego, San Diego; University of California San Francisco, San Francisco, CA; Radiation Therapy Oncology Group, Philadelphia, PA; University of Iowa, Iowa City, IA; Vanderbilt University Medical Center, Nashville, TN; University of Vermont, Burlington, VT; University of Virginia, Charlottesville, VA; The George Washington..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.166.2.3336733"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880140505"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.10.2113"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80089-3"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00092-8"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200010)22:7<687::AID-HED8>3.0.CO;2-W"},{"key":"R7","unstructured":"Kumar P, Wan J, Vieira F, et al: Five year outcome analyses following treatment of stage III\/IV head and neck (H\/N) squamous cell carcinoma (SCCa) using supradose intra-arterial targeted cisplatin (SIT-P) and concurrent radiation therapy (RT). 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