{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:20:19Z","timestamp":1780474819911,"version":"3.54.1"},"reference-count":29,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2006,3,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To assess the diagnostic performance of positron emission tomography\/computed tomography (PET\/CT) using <jats:sup>18<\/jats:sup>F-fluorodeoxyglucose (FDG) for N- and M-staging of cutaneous melanoma. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> This is a retrospective and blinded study of 250 consecutive patients (105 women, 145 men; age 58 \u00b1 16 years) who underwent FDG-PET\/CT for staging of cutaneous melanoma at different time points in the course of disease. Whole-body FDG-PET\/CT was performed 101 \u00b1 21 minutes postinjection of 371 \u00b1 41 MBq FDG. Diagnostic accuracy for N- and M-staging was determined for CT alone, PET alone, and PET\/CT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> PET\/CT detected significantly more visceral and nonvisceral metastases than PET alone and CT alone (98.7%, 88.8%, and 69.7%, respectively). PET\/CT imaging thus provided significantly more accurate interpretations regarding overall N- and M-staging than PET alone and CT alone. Overall N- and M-stage was correctly determined by PET\/CT in 243 of 250 patients (97.2%; 95% CI, 95.2% to 99.4%) compared with 232 patients (92.8%; 95% CI, 89.6% to 96.0%) by PET, and 197 patients (78.8%; 95% CI, 73.7% to 83.9%) by CT. All differences were significant. Accuracy of PET\/CT was significantly higher than that of PET and CT for M-staging (0.98 v 0.93 and 0.84) and significantly higher than that of CT for N-Staging (0.98 v 0.86). Change of treatment according to PET\/CT findings occurred in 121 patients (48.4%). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The diagnostic performance of FDG-PET\/CT for N- and M-staging of melanoma patients suggests its use for whole-body tumor staging, especially for detection or exclusion of distant metastases. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.03.5634","type":"journal-article","created":{"date-parts":[[2006,2,28]],"date-time":"2006-02-28T00:37:43Z","timestamp":1141087063000},"page":"1178-1187","source":"Crossref","is-referenced-by-count":230,"title":["Diagnostic Performance of Whole Body Dual Modality <sup>18<\/sup>F-FDG PET\/CT Imaging for N- and M-Staging of Malignant Melanoma: Experience With 250 Consecutive Patients"],"prefix":"10.1200","volume":"24","author":[{"given":"Michael J.","family":"Reinhardt","sequence":"first","affiliation":[{"name":"From the Departments of Nuclear Medicine, Radiology, and Dermatology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexius Y.","family":"Joe","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Radiology, and Dermatology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Jaeger","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Radiology, and Dermatology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Huber","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Radiology, and Dermatology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Matthies","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Radiology, and Dermatology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bucerius","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Radiology, and Dermatology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Roedel","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Radiology, and Dermatology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Strunk","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Radiology, and Dermatology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bieber","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Radiology, and Dermatology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Juergen","family":"Biersack","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Radiology, and Dermatology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"T\u00fcting","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Radiology, and Dermatology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70937-5"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.54.1.8"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.16.3622"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.16.3635"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(91)90056-R"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910315)67:6<1544::AID-CNCR2820670614>3.0.CO;2-0"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2004.06.001"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2002.02059.x"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010415)91:8<1530::AID-CNCR1162>3.0.CO;2-#"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041245"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.24.3199"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.120"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-1097-6"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1053\/snuc.2003.127307"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000901)89:5<1019::AID-CNCR11>3.0.CO;2-0"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.01.023"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200209000-00010"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1007\/BF02574480"},{"key":"R23","unstructured":"Fuster D, Chiang S, Johnson G, et al: Is 18F-FDG PET more accurate than standard diagnostic procedures in the detection of suspected recurrent melanoma? J Nucl Med 45:1323,2004-1327,"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1002\/jso.1102"},{"key":"R26","unstructured":"Beyer T, Townsend DW, Brun T, et al: A combined PET\/CT scanner for clinical oncology. J Nucl Med 41:1369,2000-1379,"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.5.1770"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.5.1508"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.7-4-271"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(03)00147-1"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.091"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2323030985"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1016\/S1536-1632(01)00003-8"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2005.03.5634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T21:02:57Z","timestamp":1653512577000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2005.03.5634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,1]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,3,1]]}},"alternative-id":["10.1200\/JCO.2005.03.5634"],"URL":"https:\/\/doi.org\/10.1200\/jco.2005.03.5634","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,1]]}}}