{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:48:43Z","timestamp":1793468923426,"version":"4.5.0"},"reference-count":72,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Although peripheral T-cell lymphoma, unspecified (PTCL\/U), is the most common T-cell tumor in Western countries, no study to date has been based on the application of a wide panel of markers to a large series of patients and assessed the impact of phenotype on survival. We evaluated the expression of 19 markers in 148 PTCLs\/U and 45 PTCLs of the angioimmunoblastic type (AILD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>The analysis was performed on tissue microarrays by immunohistochemistry and in situ hybridization. Clinical data were available in 93 PTCL\/U patients, most of whom had been included in a previous study proposing a prognostic index (PIT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An aberrant phenotype with frequent loss of CD5 and\/or CD7 was typical for PTCLs, irrespective of whether they were U or AILD. Aberrantly expressed proteins rarely included CD20, CD15, and CD30. Positivity for Epstein-Barr virus\u2013associated small RNAs and CD15 expression emerged as adverse prognostic factors. Among PTCLs\/U, the proliferation-associated protein Ki-67 turned out to be prognostically relevant and was integrated in a new predictive score, incorporating age (&gt; 60 years), high lactate dehydrogenase, poor performance status, and Ki-67 \u2265 80%. This score was associated with the patient outcome (P &lt; .0001) and was found to be more robust than PIT (P = .0043) in the present series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our retrospective analysis shows a wide range of protein expression in PTCLs and proposes a new prognostic index. The latter represents one of the first examples of mixed score (including patient- and tumor-specific factors) applied to malignant lymphomas and may be the basis for future prospective therapeutic trials.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.03.6327","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T00:38:55Z","timestamp":1145925535000},"page":"2472-2479","source":"Crossref","is-referenced-by-count":351,"title":["Marker Expression in Peripheral T-Cell Lymphoma: A Proposed Clinical-Pathologic Prognostic Score"],"prefix":"10.1200","volume":"24","author":[{"given":"Philip","family":"Went","sequence":"first","affiliation":[{"name":"From the Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli,\u201d Hematology and Hematopathology Units, St Orsola-Malpighi Hospital, University of Bologna, Bologna; Hematology Unit, S. Croce and Carle Hospital, Cuneo; Institute of Pathology, Perugia University in Terni, Terni; Institute of Hematology, Perugia University, Perugia; Division of Pathology, Spedali Riuniti di Bergamo, Bergamo; Anatomy Pathology Section, Department of Human Pathology, University of Pavia, Pavia; Division of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Agostinelli","sequence":"additional","affiliation":[{"name":"From the Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli,\u201d Hematology and Hematopathology Units, St Orsola-Malpighi Hospital, University of Bologna, Bologna; Hematology Unit, S. Croce and Carle Hospital, Cuneo; Institute of Pathology, Perugia University in Terni, Terni; Institute of Hematology, Perugia University, Perugia; Division of Pathology, Spedali Riuniti di Bergamo, Bergamo; Anatomy Pathology Section, Department of Human Pathology, University of Pavia, Pavia; Division of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gallamini","sequence":"additional","affiliation":[{"name":"From the Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli,\u201d Hematology and Hematopathology Units, St Orsola-Malpighi Hospital, University of Bologna, Bologna; Hematology Unit, S. Croce and Carle Hospital, Cuneo; Institute of Pathology, Perugia University in Terni, Terni; Institute of Hematology, Perugia University, Perugia; Division of Pathology, Spedali Riuniti di Bergamo, Bergamo; Anatomy Pathology Section, Department of Human Pathology, University of Pavia, Pavia; Division of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Paolo","family":"Piccaluga","sequence":"additional","affiliation":[{"name":"From the Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli,\u201d Hematology and Hematopathology Units, St Orsola-Malpighi Hospital, University of Bologna, Bologna; Hematology Unit, S. Croce and Carle Hospital, Cuneo; Institute of Pathology, Perugia University in Terni, Terni; Institute of Hematology, Perugia University, Perugia; Division of Pathology, Spedali Riuniti di Bergamo, Bergamo; Anatomy Pathology Section, Department of Human Pathology, University of Pavia, Pavia; Division of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ascani","sequence":"additional","affiliation":[{"name":"From the Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli,\u201d Hematology and Hematopathology Units, St Orsola-Malpighi Hospital, University of Bologna, Bologna; Hematology Unit, S. Croce and Carle Hospital, Cuneo; Institute of Pathology, Perugia University in Terni, Terni; Institute of Hematology, Perugia University, Perugia; Division of Pathology, Spedali Riuniti di Bergamo, Bergamo; Anatomy Pathology Section, Department of Human Pathology, University of Pavia, Pavia; Division of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sabattini","sequence":"additional","affiliation":[{"name":"From the Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli,\u201d Hematology and Hematopathology Units, St Orsola-Malpighi Hospital, University of Bologna, Bologna; Hematology Unit, S. Croce and Carle Hospital, Cuneo; Institute of Pathology, Perugia University in Terni, Terni; Institute of Hematology, Perugia University, Perugia; Division of Pathology, Spedali Riuniti di Bergamo, Bergamo; Anatomy Pathology Section, Department of Human Pathology, University of Pavia, Pavia; Division of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bacci","sequence":"additional","affiliation":[{"name":"From the Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli,\u201d Hematology and Hematopathology Units, St Orsola-Malpighi Hospital, University of Bologna, Bologna; Hematology Unit, S. Croce and Carle Hospital, Cuneo; Institute of Pathology, Perugia University in Terni, Terni; Institute of Hematology, Perugia University, Perugia; Division of Pathology, Spedali Riuniti di Bergamo, Bergamo; Anatomy Pathology Section, Department of Human Pathology, University of Pavia, Pavia; Division of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunangelo","family":"Falini","sequence":"additional","affiliation":[{"name":"From the Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli,\u201d Hematology and Hematopathology Units, St Orsola-Malpighi Hospital, University of Bologna, Bologna; Hematology Unit, S. 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Croce and Carle Hospital, Cuneo; Institute of Pathology, Perugia University in Terni, Terni; Institute of Hematology, Perugia University, Perugia; Division of Pathology, Spedali Riuniti di Bergamo, Bergamo; Anatomy Pathology Section, Department of Human Pathology, University of Pavia, Pavia; Division of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Paulli","sequence":"additional","affiliation":[{"name":"From the Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli,\u201d Hematology and Hematopathology Units, St Orsola-Malpighi Hospital, University of Bologna, Bologna; Hematology Unit, S. 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