{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:21:26Z","timestamp":1790972486109,"version":"4.1.0"},"reference-count":34,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2006,4,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of clofarabine, a novel deoxyadenosine analog, in pediatric patients with refractory or relapsed acute lymphoblastic leukemia (ALL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      In a phase II, open-label, multicenter study, 61 pediatric patients with refractory or relapsed ALL received clofarabine 52 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      intravenously over 2 hours daily for 5 days, every 2 to 6 weeks. The median age was 12 years (range, 1 to 20 years), and the median number of prior regimens was three (range, two to six regimens).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The response rate was 30%, consisting of seven complete remissions (CR), five CRs without platelet recovery (CRp), and six partial remissions. Remissions were durable enough to allow patients to proceed to hematopoietic stem-cell transplantation (HSCT) after clofarabine. Median CR duration in patients who did not receive HSCT was 6 weeks, with four patients maintaining CR or CRp for 8 weeks or more (8+, 12, 37+, and 48 weeks) on clofarabine therapy alone. The most common adverse events of grade \u2265 3 were febrile neutropenia, anorexia, hypotension, and nausea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clofarabine is active as a single agent in pediatric patients with multiple relapsed or refractory ALL. The toxicity profile is as expected in this heavily pretreated patient population. Studies exploring rational combinations of clofarabine with other agents are ongoing in an effort to maximize clinical benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2005.03.8554","type":"journal-article","created":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T18:54:49Z","timestamp":1145386489000},"page":"1917-1923","source":"Crossref","is-referenced-by-count":225,"title":["Phase II Study of Clofarabine in Pediatric Patients With Refractory or Relapsed Acute Lymphoblastic Leukemia"],"prefix":"10.1200","volume":"24","author":[{"given":"Sima","family":"Jeha","sequence":"first","affiliation":[{"name":"From the St Jude Children's Research Hospital, Memphis, TN; Children's Hospital of Los Angeles, Los Angeles; Children's Hospital of San Diego, San Diego; Children's Hospital of Orange County, Orange, CA; Washington University Medical School, St Louis, MO; M.D. Anderson Cancer Center, Houston; Texas Children's Cancer Center, Houston; Cook's Children's Hospital, Fort Worth; Genzyme Oncology, San Antonio, TX; The Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Gaynon","sequence":"additional","affiliation":[{"name":"From the St Jude Children's Research Hospital, Memphis, TN; Children's Hospital of Los Angeles, Los Angeles; Children's Hospital of San Diego, San Diego; Children's Hospital of Orange County, Orange, CA; Washington University Medical School, St Louis, MO; M.D. Anderson Cancer Center, Houston; Texas Children's Cancer Center, Houston; Cook's Children's Hospital, Fort Worth; Genzyme Oncology, San Antonio, TX; The Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassem I.","family":"Razzouk","sequence":"additional","affiliation":[{"name":"From the St Jude Children's Research Hospital, Memphis, TN; Children's Hospital of Los Angeles, Los Angeles; Children's Hospital of San Diego, San Diego; Children's Hospital of Orange County, Orange, CA; Washington University Medical School, St Louis, MO; M.D. Anderson Cancer Center, Houston; Texas Children's Cancer Center, Houston; Cook's Children's Hospital, Fort Worth; Genzyme Oncology, San Antonio, TX; The Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Franklin","sequence":"additional","affiliation":[{"name":"From the St Jude Children's Research Hospital, Memphis, TN; Children's Hospital of Los Angeles, Los Angeles; Children's Hospital of San Diego, San Diego; Children's Hospital of Orange County, Orange, CA; Washington University Medical School, St Louis, MO; M.D. Anderson Cancer Center, Houston; Texas Children's Cancer Center, Houston; Cook's Children's Hospital, Fort Worth; Genzyme Oncology, San Antonio, TX; The Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kadota","sequence":"additional","affiliation":[{"name":"From the St Jude Children's Research Hospital, Memphis, TN; Children's Hospital of Los Angeles, Los Angeles; Children's Hospital of San Diego, San Diego; Children's Hospital of Orange County, Orange, CA; Washington University Medical School, St Louis, MO; M.D. Anderson Cancer Center, Houston; Texas Children's Cancer Center, Houston; Cook's Children's Hospital, Fort Worth; Genzyme Oncology, San Antonio, TX; The Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violet","family":"Shen","sequence":"additional","affiliation":[{"name":"From the St Jude Children's Research Hospital, Memphis, TN; Children's Hospital of Los Angeles, Los Angeles; Children's Hospital of San Diego, San Diego; Children's Hospital of Orange County, Orange, CA; Washington University Medical School, St Louis, MO; M.D. Anderson Cancer Center, Houston; Texas Children's Cancer Center, Houston; Cook's Children's Hospital, Fort Worth; Genzyme Oncology, San Antonio, TX; The Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Luchtman-Jones","sequence":"additional","affiliation":[{"name":"From the St Jude Children's Research Hospital, Memphis, TN; Children's Hospital of Los Angeles, Los Angeles; Children's Hospital of San Diego, San Diego; Children's Hospital of Orange County, Orange, CA; Washington University Medical School, St Louis, MO; M.D. Anderson Cancer Center, Houston; Texas Children's Cancer Center, Houston; Cook's Children's Hospital, Fort Worth; Genzyme Oncology, San Antonio, TX; The Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rytting","sequence":"additional","affiliation":[{"name":"From the St Jude Children's Research Hospital, Memphis, TN; Children's Hospital of Los Angeles, Los Angeles; Children's Hospital of San Diego, San Diego; Children's Hospital of Orange County, Orange, CA; Washington University Medical School, St Louis, MO; M.D. Anderson Cancer Center, Houston; Texas Children's Cancer Center, Houston; Cook's Children's Hospital, Fort Worth; Genzyme Oncology, San Antonio, TX; The Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R.","family":"Bomgaars","sequence":"additional","affiliation":[{"name":"From the St Jude Children's Research Hospital, Memphis, TN; Children's Hospital of Los Angeles, Los Angeles; Children's Hospital of San Diego, San Diego; Children's Hospital of Orange County, Orange, CA; Washington University Medical School, St Louis, MO; M.D. Anderson Cancer Center, Houston; Texas Children's Cancer Center, Houston; Cook's Children's Hospital, Fort Worth; Genzyme Oncology, San Antonio, TX; The Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Rheingold","sequence":"additional","affiliation":[{"name":"From the St Jude Children's Research Hospital, Memphis, TN; 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