{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:26:50Z","timestamp":1790771210587,"version":"4.1.0"},"reference-count":41,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,8,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Noninvasive lesions involving the lobules of the breast are increasingly diagnosed as incidental microscopic findings at the time of lumpectomy or core-needle biopsy. We investigated the incidence rates of invasive breast cancer (IBC) after a diagnosis of lobular carcinoma-in-situ (LCIS) by using Surveillance, Epidemiology, and End Results (SEER) data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients (N = 4,853) having a diagnosis of primary LCIS in the time period of 1973 to 1998 were identified using the SEER Public Use CD-ROM data. The database was then searched for patients with subsequent primary IBC occurrences (n = 350). The clinical and pathologic characteristics of patients with subsequent primary IBCs were compared with the characteristics of patients with primary IBCs attained during the same time period (N = 255,114).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence of IBC increased over time from diagnosis of LCIS, with 7.1% \u00b1 0.5% incidence of IBC at 10 years. IBCs detected after partial mastectomy occurred in either breast (46% ipsilateral and 54% contralateral); however, after mastectomy, most IBCs were contralateral (94.7%). IBCs occurring after LCIS more often represented invasive lobular histology (23.1%) compared with primary IBCs (6.5%). The standardized incidence ratio (the ratio of observed to expected cases) for developing IBC was 2.4 (95% CI, 2.1 to 2.6) adjusted for age and year of diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LCIS is associated with increased risk of subsequent invasive disease, with equal predisposition in either breast. The minimum risk of developing IBC after LCIS is 7.1% at 10 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2005.04.038","type":"journal-article","created":{"date-parts":[[2005,8,18]],"date-time":"2005-08-18T18:18:02Z","timestamp":1124389082000},"page":"5534-5541","source":"Crossref","is-referenced-by-count":211,"title":["Bilateral Risk for Subsequent Breast Cancer After Lobular Carcinoma-In-Situ: Analysis of Surveillance, Epidemiology, and End Results Data"],"prefix":"10.1200","volume":"23","author":[{"given":"Paul J.","family":"Chuba","sequence":"first","affiliation":[{"name":"From the Department of Radiation Oncology, St John Hospital Van Elslander Cancer Center and Webber Cancer Center, Grosse Pointe; Department of Pediatrics, Children's Hospital of Michigan; Department of Family Practice, Wayne State University School of Medicine, Detroit; Department of Pathology, University of Michigan, Ann Arbor, MI; Department of Radiation Oncology, and Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merlin R.","family":"Hamre","sequence":"additional","affiliation":[{"name":"From the Department of Radiation Oncology, St John Hospital Van Elslander Cancer Center and Webber Cancer Center, Grosse Pointe; Department of Pediatrics, Children's Hospital of Michigan; Department of Family Practice, Wayne State University School of Medicine, Detroit; Department of Pathology, University of Michigan, Ann Arbor, MI; Department of Radiation Oncology, and Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Yap","sequence":"additional","affiliation":[{"name":"From the Department of Radiation Oncology, St John Hospital Van Elslander Cancer Center and Webber Cancer Center, Grosse Pointe; Department of Pediatrics, Children's Hospital of Michigan; Department of Family Practice, Wayne State University School of Medicine, Detroit; Department of Pathology, University of Michigan, Ann Arbor, MI; Department of Radiation Oncology, and Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Severson","sequence":"additional","affiliation":[{"name":"From the Department of Radiation Oncology, St John Hospital Van Elslander Cancer Center and Webber Cancer Center, Grosse Pointe; Department of Pediatrics, Children's Hospital of Michigan; Department of Family Practice, Wayne State University School of Medicine, Detroit; Department of Pathology, University of Michigan, Ann Arbor, MI; Department of Radiation Oncology, and Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lucas","sequence":"additional","affiliation":[{"name":"From the Department of Radiation Oncology, St John Hospital Van Elslander Cancer Center and Webber Cancer Center, Grosse Pointe; Department of Pediatrics, Children's Hospital of Michigan; Department of Family Practice, Wayne State University School of Medicine, Detroit; Department of Pathology, University of Michigan, Ann Arbor, MI; Department of Radiation Oncology, and Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falah","family":"Shamsa","sequence":"additional","affiliation":[{"name":"From the Department of Radiation Oncology, St John Hospital Van Elslander Cancer Center and Webber Cancer Center, Grosse Pointe; Department of Pediatrics, Children's Hospital of Michigan; Department of Family Practice, Wayne State University School of Medicine, Detroit; Department of Pathology, University of Michigan, Ann Arbor, MI; Department of Radiation Oncology, and Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Aref","sequence":"additional","affiliation":[{"name":"From the Department of Radiation Oncology, St John Hospital Van Elslander Cancer Center and Webber Cancer Center, Grosse Pointe; Department of Pediatrics, Children's Hospital of Michigan; Department of Family Practice, Wayne State University School of Medicine, Detroit; Department of Pathology, University of Michigan, Ann Arbor, MI; Department of Radiation Oncology, and Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","unstructured":"Foote FW Jr, Stewart FW: Lobular carcinoma in situ: A rare form of mammary cancer. 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