{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:35:50Z","timestamp":1775565350394,"version":"3.50.1"},"reference-count":29,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2006,3,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To determine how to use node response on computed tomography (CT) to indicate the need for neck dissection. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Five hundred fifty patients with lymph node\u2013positive head and neck cancer were treated between 1990 and 2002 with radiotherapy (RT) at a median dose of 74.4 Gy; 24% of these patients (n = 133) were treated with chemotherapy. Three hundred forty-one patients (62%) underwent planned post-RT neck dissection. Physical examination and contrast-enhanced CT were performed 30 days after completion of RT. CT images were reviewed in 211 patients for lymph node size (largest axial dimension) and presence of a focal abnormality (lucency, enhancement, or calcification). By correlating post-RT CT to neck dissection pathology, criteria associated with a low likelihood of residual disease were identified. A subset of patients who fit these criteria of radiographic response who did not undergo post-RT neck dissection was observed for recurrence. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Radiographic complete response (rCR) was defined as the absence of any large (&gt; 1.5 cm) or focally abnormal lymph node. Correlation of response with neck dissection pathology indicated a negative predictive value of 77% for complete clinical response and 94% for rCR. In 32 patients (median follow-up time, 3.2 years) with rCR who did not undergo post-RT neck dissection, the 5-year ultimate neck control rate (100%) and cause-specific survival rate (72%) were not significantly different from the rates of patients with a negative post-RT neck dissection. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Patients with rCR 4 weeks after RT can be spared from a post-RT neck dissection regardless of initial node stage. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.04.6052","type":"journal-article","created":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T23:58:03Z","timestamp":1142899083000},"page":"1421-1427","source":"Crossref","is-referenced-by-count":138,"title":["Postradiotherapy Neck Dissection for Lymph Node\u2013Positive Head and Neck Cancer: The Use of Computed Tomography to Manage the Neck"],"prefix":"10.1200","volume":"24","author":[{"given":"Stanley L.","family":"Liauw","sequence":"first","affiliation":[{"name":"From the Departments of Radiation Oncology, Radiology, and Otolaryngology, University of Florida College of Medicine, Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony A.","family":"Mancuso","sequence":"additional","affiliation":[{"name":"From the Departments of Radiation Oncology, Radiology, and Otolaryngology, University of Florida College of Medicine, Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Amdur","sequence":"additional","affiliation":[{"name":"From the Departments of Radiation Oncology, Radiology, and Otolaryngology, University of Florida College of Medicine, Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Morris","sequence":"additional","affiliation":[{"name":"From the Departments of Radiation Oncology, Radiology, and Otolaryngology, University of Florida College of Medicine, Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas B.","family":"Villaret","sequence":"additional","affiliation":[{"name":"From the Departments of Radiation Oncology, Radiology, and Otolaryngology, University of Florida College of Medicine, Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Werning","sequence":"additional","affiliation":[{"name":"From the Departments of Radiation Oncology, Radiology, and Otolaryngology, University of Florida College of Medicine, Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Mendenhall","sequence":"additional","affiliation":[{"name":"From the Departments of Radiation Oncology, Radiology, and Otolaryngology, University of Florida College of Medicine, Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R1","unstructured":"Ries LAG, Eisner MP, Kosary CL, et al: (eds): SEER Cancer Statistics Review, 1975-2002.  Bethesda, MD, National Cancer Institute, 2005"},{"key":"R2","unstructured":"Kutler DI, Patel SG, Shah JP: The role of neck dissection following definitive chemoradiation. Oncology (Williston Park) 18: 993,2004 -998,"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10187"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(86)90030-1"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199611\/12)18:6<552::AID-HED10>3.0.CO;2-A"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6823(1998)6:1<52::AID-ROI6>3.0.CO;2-H"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(99)00182-6"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01468-7"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02603-7"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Cox DR: Regression models and life tables. J R Stat Soc B 34: 187,1972 -220,","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.09.004"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199710)19:7<559::AID-HED1>3.0.CO;2-6"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880130303"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(86)80015-9"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199910)21:7<591::AID-HED1>3.0.CO;2-Y"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10293"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00193-7"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10394"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.8.950"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-001-0644-x"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199911000-00010"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2390"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1136"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)01625-0"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.05.058"},{"key":"R27","doi-asserted-by":"crossref","unstructured":"Yao M, Buatti JM, Dornfeld KJ, et al: Can post-RT FDG PET accurately predict the pathologic status in neck dissection after radiation for locally advanced head and neck cancer? In regard to Rogers, et al (Int J Radiat Oncol Biol Phys 2004;58:694-697). Int J Radiat Oncol Biol Phys 61: 306,2005 -307,","DOI":"10.1016\/j.ijrobp.2004.05.044"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20130"},{"key":"R29","unstructured":"Million RA, Cassisi NJ: Management of Head and Neck Cancer: A Multidisciplinary Approach (ed 2).  Philadelphia, PA, J.B. Lippincott Company, 1994"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2005.04.6052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T21:00:44Z","timestamp":1653512444000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2005.04.6052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,20]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,3,20]]}},"alternative-id":["10.1200\/JCO.2005.04.6052"],"URL":"https:\/\/doi.org\/10.1200\/jco.2005.04.6052","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,20]]}}}