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In this review, we describe our current state of understanding of the genetic basis of AML and MPD, with a specific focus on pathogenetic and therapeutic significance. Specific examples discussed include RAS mutations, KIT mutations, FLT3 mutations, and core binding factor rearrangements in AML, and JAK2 mutations in polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis. <\/jats:p>","DOI":"10.1200\/jco.2005.05.010","type":"journal-article","created":{"date-parts":[[2005,9,9]],"date-time":"2005-09-09T04:07:52Z","timestamp":1126238872000},"page":"6285-6295","source":"Crossref","is-referenced-by-count":288,"title":["Genetics of Myeloid Malignancies: Pathogenetic and Clinical Implications"],"prefix":"10.1200","volume":"23","author":[{"given":"Stefan","family":"Fr\u00f6hling","sequence":"first","affiliation":[{"name":"From the Brigham and Women's Hospital; Howard Hughes Medical Institute, Harvard Medical School, Boston MA; and the Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Scholl","sequence":"additional","affiliation":[{"name":"From the Brigham and Women's Hospital; Howard Hughes Medical Institute, Harvard Medical School, Boston MA; and the Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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