{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:34:08Z","timestamp":1780479248317,"version":"3.54.1"},"reference-count":17,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2007,3,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The histologic finding of teratoma occurs in approximately 40% of all postchemotherapy retroperitoneal lymph node dissections (PC-RPLND). We evaluated patients at our institution undergoing initial PC-RPLND for teratoma to determine their clinical outcome. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> We identified 210 patients from 1989 to 2003 with nonseminomatous germ cell tumors (NSGCT) who underwent initial PC-RPLND and were found to have only teratoma in the retroperitoneum. Clinical and pathologic information was obtained from our prospective surgical database, and clinical outcome was reported. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Of the 210 patients in our series, 192 (92%) received only induction chemotherapy, and 18 (9%) required additional chemotherapy regimens. PC-RPLND pathology revealed mature teratoma in 178 patients (85%), immature teratoma in 15 patients (7%), and teratoma with malignant transformation in 17 patients (8%). With a median follow-up time for survivors of 37 months, disease recurred in 30 patients. The probability of remaining free of disease recurrence at 5 and 10 years was 83% and 80%, respectively. Of the 30 patients with disease recurrence, 10 (33%) had recurrence with teratoma, five (17%) had recurrence with teratoma with malignant transformation, and 15 (50%) had recurrence with viable germ cell tumor. On multivariable analysis, residual mass size and International Germ Cell Cancer Collaborative Group (IGCCCG) risk classification were predictors of disease recurrence (P &lt; .0005 and = .001, respectively). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> PC-RPLND remains critical in the management of patients with NSGCT. Patients found to have teratoma at PC-RPLND have a 10-year probability of freedom from recurrence of 80%. The size of the residual mass and IGCCCG risk classification were significant predictors of disease recurrence. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.05.4791","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T18:29:01Z","timestamp":1170440941000},"page":"1033-1037","source":"Crossref","is-referenced-by-count":91,"title":["Long-Term Clinical Outcome After Postchemotherapy Retroperitoneal Lymph Node Dissection in Men With Residual Teratoma"],"prefix":"10.1200","volume":"25","author":[{"given":"Brett S.","family":"Carver","sequence":"first","affiliation":[{"name":"From the Department of Urology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby","family":"Shayegan","sequence":"additional","affiliation":[{"name":"From the Department of Urology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Serio","sequence":"additional","affiliation":[{"name":"From the Department of Urology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Motzer","sequence":"additional","affiliation":[{"name":"From the Department of Urology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J.","family":"Bosl","sequence":"additional","affiliation":[{"name":"From the Department of Urology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Sheinfeld","sequence":"additional","affiliation":[{"name":"From the Department of Urology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","unstructured":"Sheinfeld J, Herr HW: Role of surgery in management of germ cell tumor. Semin Oncol 25:203,1998-209,"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.10.1683"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.5.1177"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.5.818"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.4.569"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64035-7"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.5.1170"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)54256-1"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)39044-4"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)46031-9"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980401)82:7<1343::AID-CNCR18>3.0.CO;2-6"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000154013.96349.36"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.03.019"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00579-X"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.2.594"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63754-6"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.019"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2005.05.4791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T21:16:59Z","timestamp":1653513419000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2005.05.4791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,20]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,3,20]]}},"alternative-id":["10.1200\/JCO.2005.05.4791"],"URL":"https:\/\/doi.org\/10.1200\/jco.2005.05.4791","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,20]]}}}