{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:49:56Z","timestamp":1791020996955,"version":"4.1.0"},"reference-count":41,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2006,7,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Helicobacter pylori infection and host susceptibility interact to develop gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and activation of specific T cells might play a crucial role in this process. Recent investigations show that the CTLA4, CD28, and ICOS genes are located on chromosome 2q33 and their polymorphisms confer susceptibility to infectious and immune diseases through deregulation of T-cell stimulation. We aimed to determine the role of CTLA4, CD28, and ICOS polymorphisms in gastric MALT lymphoma. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Genotyping for CTLA4 (49 A\/G, \u2212318 C\/T, and CT60 A\/G), CD28 (IVS3+ 17T\/C), and ICOS (c.602 A\/C and c.1624C\/T) was performed for 62 patients with gastric MALT lymphoma and compared with 250 unrelated healthy controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> H pylori infection was significantly higher in patients with gastric MALT lymphoma (90.3%) compared with controls (66.4%; P &lt; .001). The CTLA4 \u2212318 C\/T genotype was associated with a lower risk of developing gastric MALT lymphoma (odds ratio [OR] = 0.3; P = .022), whereas CTLA4 49 G\/G genotype was linked to a higher risk (OR = 4.1; P = .044). In patients with H pylori infection, CTLA4 49 G\/G genotype was associated with an even higher risk (OR = 6.4; P = .047). Carriage of the tightly linked \u2212318C \u201349G haplotype conferred a four-fold higher susceptibility to MALT lymphoma (OR = 4.2; P = .042). Complete remission after H pylori eradication was related to tumor stage but not to genotypes or haplotypes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> These results indicate a genetic link of CTLA4 gene polymorphisms to development of gastric MALT lymphoma and indirectly support the crucial role of host activated T cells in the MALT lymphomagenesis. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.05.5434","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T23:08:23Z","timestamp":1153264103000},"page":"3483-3489","source":"Crossref","is-referenced-by-count":70,"title":["Association of T-Cell Regulatory Gene Polymorphisms With Susceptibility to Gastric Mucosa-Associated Lymphoid Tissue Lymphoma"],"prefix":"10.1200","volume":"24","author":[{"given":"Tsu-Yao","family":"Cheng","sequence":"first","affiliation":[{"name":"From the Department of Laboratory Medicine, Division of Gastroenterology, Department of Internal Medicine, and Departments of Pathology, Surgery, and Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institute; and the Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaw-Town","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine, Division of Gastroenterology, Department of Internal Medicine, and Departments of Pathology, Surgery, and Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institute; and the Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Tzong","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine, Division of Gastroenterology, Department of Internal Medicine, and Departments of Pathology, Surgery, and Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institute; and the Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Tung","family":"Shun","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine, Division of Gastroenterology, Department of Internal Medicine, and Departments of Pathology, Surgery, and Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institute; and the Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Po","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine, Division of Gastroenterology, Department of Internal Medicine, and Departments of Pathology, Surgery, and Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institute; and the Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Tsang","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine, Division of Gastroenterology, Department of Internal Medicine, and Departments of Pathology, Surgery, and Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine; Division of Cancer Research, National Health Research Institute; and the Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsang-En","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Laboratory Medicine, Division of Gastroenterology, Department of Internal Medicine, and Departments of Pathology, Surgery, and Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine; 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