{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:02:37Z","timestamp":1768996957368,"version":"3.49.0"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To determine the impact of translocation t(11;18) on response to oral alkylating agents in gastric mucosa-associated lymphoid tissue lymphoma (GML). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Fifty-three patients with a GML were studied. Helicobacter pylori--positive patients (n = 34) received anti\u2013H pylori treatment and H pylori\u2013negative patients (n = 19) or patients who failed to respond to anti\u2013H pylori treatment received oral alkylating agents. t(11;18) was detected by reverse transcription polymerase chain reaction from frozen gastric biopsies. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> t(11;18) was detected in 32% of patients. It was more prevalent in H pylori--negative as compared with H pylori--positive patients (12 of 19 v five of 34 patients; P = .0005). Among 31 H pylori\u2013eradicated patients, t(11;18) was detected in three patients, all of whom experienced treatment failure, and it was absent in 28 patients: 21 patients (75%) were in remission and seven patients (25%) experienced treatment failure (P = .03). Among 21 patients who received an alkylating agent, t(11;18) was detected in 12 patients: five patients (42%) were in remission and seven patients (58%) experienced treatment failure. t(11;18) was absent in nine patients: eight patients (89%) were in remission and one patient (11%) experienced treatment failure by the end of treatment. Four patients in remission relapsed during follow-up (median, 7 years): they all had t(11;18). Durable remission was obtained in eight (89%) of the nine patients without t(11;18) versus one of the 12 patients (8%) with t(11;18) (P = .0003). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Presence of t(11;18) in GML is predictive of resistance to oral alkylating agents, with less than 10% of durable remission at long-term follow-up. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.05.660","type":"journal-article","created":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T22:13:21Z","timestamp":1122588801000},"page":"5061-5066","source":"Crossref","is-referenced-by-count":101,"title":["Prognostic Value of Translocation t(11;18) in Tumoral Response of Low-Grade Gastric Lymphoma of Mucosa-Associated Lymphoid Tissue Type to Oral Chemotherapy"],"prefix":"10.1200","volume":"23","author":[{"given":"Micha\u00ebl","family":"L\u00e9vy","sequence":"first","affiliation":[{"name":"From the Service d'H\u00e9patologie et de Gastroent\u00e9rologie, 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