{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:25:42Z","timestamp":1791278742757,"version":"4.1.0"},"reference-count":37,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,1,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Hepatitis C virus (HCV) is endemic in some areas of Northwestern Europe and the United States. HCV has been shown to play a role in the development of both hepatocellular carcinoma and B-cell non-Hodgkin's lymphoma (B-NHL). The biologic mechanisms underlying the lymphomagenic activity of the virus so far are under investigation. In this study, the role of antiviral (anti-HCV) treatment in B-NHL associated with HCV infection is evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Thirteen patients with histologically proven low-grade B-NHL characterized by an indolent course (ie, doubling time no less than 1 year, no bulky disease) and carrying HCV infection were enrolled on the study. All patients underwent antiviral treatment alone with pegilated interferon and ribavirin. Response assessment took place at 6 and 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the twelve assessable patients, seven (58%) achieved complete response and two (16%) partial hematologic response at 14.1 \u00b1 9.7 months (range, 2 to 24 months, median follow-up, 14 months), while two had stable disease with only one patient experiencing progression of disease. Hematologic responses (complete and partial, 75%) were highly significantly associated to clearance or decrease in serum HCV viral load following treatment (P = .005). Virologic response was more likely to be seen in HCV genotype 2 (P = .035), while hematologic response did not correlate with the viral genotype. Treatment-related toxicity did not cause discontinuation of therapy in all but two patients, one of whom, however, achieved complete response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This experience strongly provides a role for antiviral treatment in patients affected by HCV-related, low-grade, B-cell NHL.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.06.008","type":"journal-article","created":{"date-parts":[[2005,1,19]],"date-time":"2005-01-19T15:17:48Z","timestamp":1106147868000},"page":"468-473","source":"Crossref","is-referenced-by-count":201,"title":["Role of Anti-Hepatitis C Virus (HCV) Treatment in HCV-Related, Low-Grade, B-Cell, Non-Hodgkin's Lymphoma: A Multicenter Italian Experience"],"prefix":"10.1200","volume":"23","author":[{"given":"Daniele","family":"Vallisa","sequence":"first","affiliation":[{"name":"From the Department of Oncology and Hematology, G. da Saliceto Hospital, Piacenza; Division of Hematology, IRCCS Policlinico San Matteo, University of Pavia, Paiva; 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