{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:56:39Z","timestamp":1791204999971,"version":"4.1.0"},"reference-count":25,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Some infectious agents contributing to lymphomagenesis have been considered targets for new therapeutic strategies. Chlamydia psittaci DNA has been detected in 80% of ocular adnexal lymphomas. The present pilot study was carried out to assess whether C psittaci\u2013eradicating antibiotic therapy is associated with tumor regression in ocular adnexal lymphomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Nine patients with C psittaci\u2013positive marginal-zone B-cell lymphoma of the ocular adnexa at diagnosis or relapse were treated with doxycycline 100 mg, bid orally, for 3 weeks. The presence of C psittaci DNA in peripheral-blood mononuclear cells (PBMCs) was also assessed before and after treatment in seven patients. Objective lymphoma regression was assessed 1, 3, and 6 months after therapy conclusion and every 6 months during follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients completed antibiotic therapy with excellent tolerability. At 1 month from doxycycline assumption, chlamydial DNA was no longer detectable in PBMCs of all four positive patients. Objective response was complete in two patients, partial response (&gt; 50%) was observed in two patients, and minimal response (&lt; 50%) was observed in three patients. Duration of response in the seven responders was 12+, 29+, 31+, 8+, 7+, 2+, and 1+ months, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>C psittaci\u2013eradicating antibiotic therapy with doxycycline is followed by objective response in patients with ocular adnexal lymphoma, even after multiple relapses of the disease. A confirmatory, large, phase II trial is warranted to confirm whether this fast, cheap, and well-tolerated therapy could replace other more aggressive strategies as first-line treatment against ocular adnexal lymphomas.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.07.083","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T00:39:22Z","timestamp":1119314362000},"page":"5067-5073","source":"Crossref","is-referenced-by-count":182,"title":["Regression of Ocular Adnexal Lymphoma After<i>Chlamydia Psittaci<\/i>\u2013Eradicating Antibiotic Therapy"],"prefix":"10.1200","volume":"23","author":[{"given":"Andr\u00e9s J.M.","family":"Ferreri","sequence":"first","affiliation":[{"name":"From the Departments of Radiochemotherapy, Pathology, Ophthalmology, and Hematology, San Raffaele H Scientific Institute, Milan; Immunovirology and Biotherapy Unit, and Division of Experimental Oncology 1, Department of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico National Cancer Institute, Aviano, Italy; 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