{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:09:09Z","timestamp":1791410949506,"version":"4.3.3"},"reference-count":38,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,4,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To study the main clinicobiologic features, response, and outcome of patients with diffuse large B-cell lymphoma (DLBCL) according to the primary site, lymph node, or different extranodal organs of the disease. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> We included 382 patients consecutively diagnosed with DLBCL in a single institution during a 13-year period. Morphology, immunophenotyping, proliferation index, differentiation profile, bcl-2\/JH rearrangement, and clinical characteristics were analyzed according to the primary site of the lymphoma. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Sites of the disease were: lymph node, 222 cases (58%); Waldeyer's ring (WR), 42 (11%); and extranodal sites, 118 (31%), including GI tract in 45 cases. Primary extranodal cases, particularly GI, showed a bcl-6 expression more frequently than nodal cases. Patients with primary WR or GI lymphomas presented with early-stage disease, no marrow infiltration, normal serum lactate dehydrogenase, and low- to low\/intermediate-risk international prognostic index (IPI) more frequently than the remainder. Complete response (CR) rate was 63%, with WR and GI lymphomas having a higher CR rate (85% and 80%, respectively) than the other groups. In the whole series, 5-year overall survival (OS) was 52%. Patients with WR or GI lymphomas showed better OS (5-year OS: 77% and 68%, respectively) than patients with nodal or other extranodal sites. In the multivariate analysis, IPI, bulky disease, and \u03b22-microglobulin were the main variables to predict OS; no nodal or extranodal site maintained their prognostic value. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> In the present series, the primary site of disease was associated with particular clinicopathologic features and outcome, though the latter largely depended on other factors. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.07.155","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T04:48:07Z","timestamp":1109134087000},"page":"2797-2804","source":"Crossref","is-referenced-by-count":225,"title":["Diffuse Large B-Cell Lymphoma: Clinical and Biological Characterization and Outcome According to the Nodal or Extranodal Primary Origin"],"prefix":"10.1200","volume":"23","author":[{"given":"Armando","family":"L\u00f3pez-Guillermo","sequence":"first","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Colomo","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Bosch","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Villamor","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Arenillas","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Munta\u00f1ola","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Montoto","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gin\u00e9","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolors","family":"Colomer","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Be\u00e0","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00edas","family":"Campo","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emili","family":"Montserrat","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology and Pathology, Hospital Cl\u00ednic, Institut de Recerca Biom\u00e8dica August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","unstructured":"Harris NL: Mature B-cell neoplasms, in EJ Jaffe, NL Harris, H Stein et al (eds): WHO Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues . 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