{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:05:32Z","timestamp":1790665532464,"version":"4.1.0"},"reference-count":47,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,7,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To compare outcomes of patients with HIV-Burkitt's lymphoma (HIV-BL) and HIV-diffuse large-cell lymphoma (HIV-DLCL) after treatment with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) or M-BACOD (methotrexate, bleomycin, cyclophosphamide, etoposide) in pre\u2013highly active antiretroviral therapy (HAART) versus HAART eras. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Three hundred sixty-three patients with AIDS-related lymphoma diagnosed from 1982 to 2003 were reviewed retrospectively, including 262 in the pre-HAART (HIV-BL, 117; HIV-DLCL, 145) and 101 in the HAART era (HIV-BL, 18; HIV-DLCL, 83). Pre-HAART included those who did not receive HAART, and HAART era included those diagnosed after January 1997 who received HAART. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> There were no significant differences between groups in terms of age, sex, history of injection drug use, prior AIDS, lactate dehydrogenase level, and disease stage at diagnosis. Compared with HIV-BL, HIV-DLCL was associated with significantly lower CD4 counts in the pre-HAART but not the HAART era. Although the overall median survival was similar for both groups in the pre-HAART era (HIV-BL, 6.4 months v HIV-DLCL, 8.3 months; P = .43), survival was significantly worse in patients with HIV-BL in the HAART era (HIV-BL, 5.7 months v HIV-DLCL, 43.2 months; P = .0003). Failure to attain complete remission and CD4 count less than 100 cells\/mm<jats:sup>3<\/jats:sup> independently predicted for poor survival in the pre-HAART era. In comparison, histology of HIV-BL and no attainment of complete remission were independent poor prognostic factors in the HAART era. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Survival of patients with HIV-DLCL has improved in the HAART era, along with CD4 count, whereas survival of similarly treated patients with HIV-BL remained poor. The current practice of using the same regimen for both groups of patients should be re-evaluated. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.11.973","type":"journal-article","created":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T00:38:37Z","timestamp":1115685517000},"page":"4430-4438","source":"Crossref","is-referenced-by-count":174,"title":["AIDS-Related Burkitt's Lymphoma Versus Diffuse Large-Cell Lymphoma in the Pre\u2013Highly Active Antiretroviral Therapy (HAART) and HAART Eras: Significant Differences in Survival With Standard Chemotherapy"],"prefix":"10.1200","volume":"23","author":[{"given":"Soon Thye","family":"Lim","sequence":"first","affiliation":[{"name":"From the Norris Comprehensive Cancer Center; Department of Epidemiology and Biostatistics; Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA; and National Cancer Centre, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roksana","family":"Karim","sequence":"additional","affiliation":[{"name":"From the Norris Comprehensive Cancer Center; 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