{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:44:55Z","timestamp":1790700295299,"version":"4.1.0"},"reference-count":20,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,5,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To determine the overall survival, progression-free survival, and toxicity associated with concurrent paclitaxel\/carboplatin and thoracic radiotherapy for completely resected patients with stage II and IIIA non\u2013small-cell lung cancer (NSCLC). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Eighty-eight eligible patients had surgical resection for pathologic stage II or IIIA disease and received postoperative paclitaxel and carboplatin. Concurrent thoracic radiotherapy at 50.4 Gy in 28 fractions for 6 weeks (1.8 Gy\/d, 5 days\/wk) was given during cycles 1 and 2. A boost of 10.8 Gy in six fractions was given for extracapsular nodal extension or T3 lesions. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Treatment compliance was acceptable, with 93% compliance for radiation therapy and 86% for chemotherapy completion. The median duration of follow-up was 56.7 months (range, 17 to 61 months). The median overall survival time was 56.3 months, with 1-, 2-, and 3-year survival rates of 86%, 70%, and 61%, respectively. The 1-, 2-, and 3- year progression-free survival rates were 70%, 57%, and 50%, respectively. Brain metastasis occurred as the sole site of first failure in 11%, and 9% failed in other metastatic sites as first failure. Of the 43 patients who died, the cause of death was the treated cancer in 31 (35%). Local failure was a component of first failure in 15% of patients. Toxicities were acceptable. An overall survival comparison to Eastern Cooperative Oncology Group 3590 is favorable. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The mature results of this trial suggest an improved overall and progression-free survival in this group of resected NSCLC patients, compared with previously reported trials. A phase III trial comparing this treatment regimen with standard therapy seems warranted. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.12.120","type":"journal-article","created":{"date-parts":[[2005,5,20]],"date-time":"2005-05-20T23:31:45Z","timestamp":1116631905000},"page":"3480-3487","source":"Crossref","is-referenced-by-count":93,"title":["Phase II Trial of Postoperative Adjuvant Paclitaxel\/Carboplatin and Thoracic Radiotherapy in Resected Stage II and IIIA Non\u2013Small-Cell Lung Cancer: Promising Long-Term Results of the Radiation Therapy Oncology Group\u2014RTOG 9705"],"prefix":"10.1200","volume":"23","author":[{"given":"Jeffrey D.","family":"Bradley","sequence":"first","affiliation":[{"name":"From the Washington University, St Louis; Phelps County Regional Medical Center, Rolla, MO; Radiation Therapy Oncology Group; University of Pennsylvania Hospital; Thomas Jefferson University Hospital, Philadelphia, PA; Johns Hopkins University, Baltimore, MD; University of Rochester, Rochester, NY; 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University of Pennsylvania Hospital; Thomas Jefferson University Hospital, Philadelphia, PA; Johns Hopkins University, Baltimore, MD; University of Rochester, Rochester, NY; UCLA Medical Center, Los Angeles, CA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Southeast Cancer Control Consortium, Winston Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Ettinger","sequence":"additional","affiliation":[{"name":"From the Washington University, St Louis; Phelps County Regional Medical Center, Rolla, MO; Radiation Therapy Oncology Group; University of Pennsylvania Hospital; Thomas Jefferson University Hospital, Philadelphia, PA; Johns Hopkins University, Baltimore, MD; University of Rochester, Rochester, NY; UCLA Medical Center, Los Angeles, CA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Southeast Cancer Control Consortium, Winston Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"From the Washington University, St Louis; 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