{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T01:54:20Z","timestamp":1783821260576,"version":"3.55.0"},"reference-count":24,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,2,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To evaluate the value of lymphatic vessel invasion (LVI) as a predictor of survival in patients with primary resected adenocarcinomas of the esophagogastric junction (AEG). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> We prospectively evaluated 459 patients undergoing primary surgical resection for tumors of the esophagogastric junction at our institution between 1992 and 2000 (180 adenocarcinomas of the distal esophagus, AEG I; 140 carcinomas of the cardia, AEG II; and 139 subcardial gastric cancers, AEG III). Median follow-up was 36.8 months. The prevalence of LVI was evaluated by two independent pathologists. Univariate and multivariate analysis of prognostic factors was performed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The total rate of LVI was 49.9%, with a significant difference between AEG I (38.9%) and AEGII\/III (57.0%, P = .0002). Univariate analysis showed a significant correlation between LVI and T category (P &lt; .0001), N category (P &lt; .0001), and resection status (R [residual tumor] category; P &lt; .0001). This was shown for the group of all AEG tumors, as well as for the subgroups AEG I and AEG II\/III. On multivariate analysis, LVI was identified as a significant and independent prognostic factor (P = .050) in the population of all patients and in patients with AEG II\/III, but not in the subgroup with AEG I. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> These data demonstrate the prognostic significance of LVI in patients with AEG tumors, with marked differences between the subgroups AEG I versus AEG II\/III. The lower prevalence and lack of prognostic significance of LVI in AEG I might be explained by inflammation involved in the pathogenesis of this entity. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.12.151","type":"journal-article","created":{"date-parts":[[2005,1,29]],"date-time":"2005-01-29T07:12:26Z","timestamp":1106982746000},"page":"874-879","source":"Crossref","is-referenced-by-count":80,"title":["Lymphatic Vessel Invasion As a Prognostic Factor in Patients With Primary Resected Adenocarcinomas of the Esophagogastric Junction"],"prefix":"10.1200","volume":"23","author":[{"given":"Burkhard H.A.","family":"von Rahden","sequence":"first","affiliation":[{"name":"From the Departments of Surgery and Pathology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert J.","family":"Stein","sequence":"additional","affiliation":[{"name":"From the Departments of Surgery and Pathology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Feith","sequence":"additional","affiliation":[{"name":"From the Departments of Surgery and Pathology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Becker","sequence":"additional","affiliation":[{"name":"From the Departments of Surgery and Pathology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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