{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:00:10Z","timestamp":1789124410271,"version":"build-2803163510"},"reference-count":50,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2005,8,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Although rare overall, marginal zone B-cell lymphoma (MZBCL) is the most common primary low-grade CNS lymphoma reported in the literature. The aim of this study is to elucidate the biology and genetic features of this unusual tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Fifteen CNS MZBCLs were studied clinically, pathologically, and genetically, including fluorescent in situ hybridization analyses with commercially available MALT1 and IgH break-apart and centromere 3, 7, 12, and 18 probes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CNS MZBCLs preferentially affect middle-aged women (female-to-male ratio, 4:1), with 93% presenting as dural-based masses mimicking meningioma. Ten patients with 1 to 7.6 years of follow-up after diagnosis showed no evidence of disease after radiation and\/or chemotherapy. Like MZBCLs outside of the CNS, they consisted of CD20<jats:sup>+<\/jats:sup>, CD3<jats:sup>\u2212<\/jats:sup>small B lymphocytes with varying degrees of plasmacytic differentiation and predominantly \u03ba light-chain restriction (78%). Lymphoid follicles with follicular colonization were seen in three patients and deposition of amyloid was noted in samples from two patients, one of which was tumefactive. Neither Bcl-6 protein nor Epstein-Barr virus\u2013encoded RNA was expressed. Trisomy 3 was detected in six of 12 patients, with no rearrangements of MALT1 or IgH and no trisomies of 7, 12, or 18 detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest that intracranial MZBCL is an indolent primary CNS lymphoma that typically presents as a meningioma-like dural-based mass. Trisomy 3, but not MALT1 or IgH translocation, is a common genetic abnormality that may contribute to the pathogenesis of this CNS lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2005.17.624","type":"journal-article","created":{"date-parts":[[2005,7,12]],"date-time":"2005-07-12T00:34:29Z","timestamp":1121128469000},"page":"5718-5727","source":"Crossref","is-referenced-by-count":142,"title":["Clinicopathologic and Genetic Profile of Intracranial Marginal Zone Lymphoma: A Primary Low-Grade CNS Lymphoma That Mimics Meningioma"],"prefix":"10.1200","volume":"23","author":[{"given":"Pang-hsien","family":"Tu","sequence":"first","affiliation":[{"name":"From the Division of Neuropathology and Section of Hematopathology, Washington University School of Medicine, St Louis, MO; Division of Neuropathology and Department of Neurology, Mayo Clinic, Rochester, MN; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Neuropathology, University of Florida College of Medicine, Gainesville, FL; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Giannini","sequence":"additional","affiliation":[{"name":"From the Division of Neuropathology and Section of Hematopathology, Washington University School of Medicine, St Louis, MO; Division of Neuropathology and Department of Neurology, Mayo Clinic, Rochester, MN; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Neuropathology, University of Florida College of Medicine, Gainesville, FL; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Judkins","sequence":"additional","affiliation":[{"name":"From the Division of Neuropathology and Section of Hematopathology, Washington University School of Medicine, St Louis, MO; Division of Neuropathology and Department of Neurology, Mayo Clinic, Rochester, MN; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Neuropathology, University of Florida College of Medicine, Gainesville, FL; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Schwalb","sequence":"additional","affiliation":[{"name":"From the Division of Neuropathology and Section of Hematopathology, Washington University School of Medicine, St Louis, MO; Division of Neuropathology and Department of Neurology, Mayo Clinic, Rochester, MN; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Neuropathology, University of Florida College of Medicine, Gainesville, FL; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Burack","sequence":"additional","affiliation":[{"name":"From the Division of Neuropathology and Section of Hematopathology, Washington University School of Medicine, St Louis, MO; Division of Neuropathology and Department of Neurology, Mayo Clinic, Rochester, MN; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Neuropathology, University of Florida College of Medicine, Gainesville, FL; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"From the Division of Neuropathology and Section of Hematopathology, Washington University School of Medicine, St Louis, MO; Division of Neuropathology and Department of Neurology, Mayo Clinic, Rochester, MN; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Neuropathology, University of Florida College of Medicine, Gainesville, FL; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.","family":"Yachnis","sequence":"additional","affiliation":[{"name":"From the Division of Neuropathology and Section of Hematopathology, Washington University School of Medicine, St Louis, MO; Division of Neuropathology and Department of Neurology, Mayo Clinic, Rochester, MN; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Neuropathology, University of Florida College of Medicine, Gainesville, FL; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Burger","sequence":"additional","affiliation":[{"name":"From the Division of Neuropathology and Section of Hematopathology, Washington University School of Medicine, St Louis, MO; Division of Neuropathology and Department of Neurology, Mayo Clinic, Rochester, MN; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Neuropathology, University of Florida College of Medicine, Gainesville, FL; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd W.","family":"Scheithauer","sequence":"additional","affiliation":[{"name":"From the Division of Neuropathology and Section of Hematopathology, Washington University School of Medicine, St Louis, MO; Division of Neuropathology and Department of Neurology, Mayo Clinic, Rochester, MN; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Neuropathology, University of Florida College of Medicine, Gainesville, FL; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"Perry","sequence":"additional","affiliation":[{"name":"From the Division of Neuropathology and Section of Hematopathology, Washington University School of Medicine, St Louis, MO; Division of Neuropathology and Department of Neurology, Mayo Clinic, Rochester, MN; Department of Pathology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA; Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; Division of Neuropathology, University of Florida College of Medicine, Gainesville, FL; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"R2","unstructured":"Altundag KM, Ozisik Y, Yalcin S, et al: Primary low-grade B-cell lymphoma of the dura in an immunocompromised patient. J Exp Clin Cancer Res 19:249,2000-251,"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Bodi I, Hussain A, Gullan RW, et al: 56-year-old female with right frontal tumor of the dura. Brain Pathol 13:417,2003-418,","DOI":"10.1111\/j.1750-3639.2003.tb00045.x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1023\/A:1019913611512"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.3.0611"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2001.00392.x"},{"key":"R7","unstructured":"Kambham N, Chang Y, Matsushima AY: Primary low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) arising in dura. Clin Neuropathol 17:311,1998-317,"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10311"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199701000-00009"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.2.0368"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Lima VS, Leite EB, Fonseca RP, et al: Primary low grade mucosa-associated B-cell lymphoma of the dura. Diagn Oncol 21:4058,2003-4063,","DOI":"10.1200\/JCO.2003.12.054"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-004-0373-2"},{"key":"R13","unstructured":"Roonprapunt C, Retech H, LaSala P et al: Primary diffuse B-cell lymphoma arising in the dura in an immunocompetent individual: Case report. J Neuropathol Exp Neurol 62:574,2003, (abstr 146)"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEON.0000024704.70250.42"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097736"},{"key":"R16","unstructured":"Jaffe ES, Harris NL, Stein H, et al: World Health Organization Classification of Tumours. Pathology & Genetics. Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France, IARC Press, 2001"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01360.x"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2216"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11893"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001615657"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1038\/nri799"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1069(200003)18:1<1::AID-HON647>3.0.CO;2-G"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2963"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403644"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64988-7"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65499-5"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203018"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.11.3601"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090769"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.1.95"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00385-3"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800029"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.2703087.x"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910115)67:2<444::AID-CNCR2820670221>3.0.CO;2-W"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.38.232"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1989.tb01605.x"},{"key":"R37","unstructured":"Ellie E, Vergier B, Duche B, et al: Local amyloid deposits in a primary central nervous system lymphoma: Study of a stereotactic brain biopsy. Clin Neuropathol 9:231,1990-233,"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021244228163"},{"key":"R39","unstructured":"Subramanian S, Bahceci E, Kanji A: Primary follicular lymphoma of the meninges: A case report. Proc Am Soc Clin Oncol 14:153,1995, (abstr 308)"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.00409.x"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000076972"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013376"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91409-F"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh135"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200101000-00023"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1038\/nri1201"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.98"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65611-8"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64157-0"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001621588"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2005.17.624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T18:39:47Z","timestamp":1683139187000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2005.17.624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,20]]},"references-count":50,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2005,8,20]]}},"alternative-id":["10.1200\/JCO.2005.17.624"],"URL":"https:\/\/doi.org\/10.1200\/jco.2005.17.624","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,20]]}}}