{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:07:11Z","timestamp":1789409231110,"version":"build-2803163510"},"reference-count":96,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2006,6,10]]},"abstract":"<jats:p> Safe, successful swallowing depends on complex events affected by head and neck cancers and their treatment. This article reviews the swallowing process, how it is affected by chemoradiotherapy, and the evaluation, prevention, and treatment of swallowing disorders. Specific recommendations are made to promote maintenance and recovery of swallowing function. <\/jats:p>","DOI":"10.1200\/jco.2006.06.0079","type":"journal-article","created":{"date-parts":[[2006,6,8]],"date-time":"2006-06-08T22:42:47Z","timestamp":1149806567000},"page":"2636-2643","source":"Crossref","is-referenced-by-count":343,"title":["Prevention and Treatment of Dysphagia and Aspiration After Chemoradiation for Head and Neck Cancer"],"prefix":"10.1200","volume":"24","author":[{"given":"David I.","family":"Rosenthal","sequence":"first","affiliation":[{"name":"From the Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, and the Department of Radiation Oncology, the University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan S.","family":"Lewin","sequence":"additional","affiliation":[{"name":"From the Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, and the Department of Radiation Oncology, the University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Eisbruch","sequence":"additional","affiliation":[{"name":"From the Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, and the Department of Radiation Oncology, the University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.4.401"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10257"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2294::AID-CNCR17>3.0.CO;2-S"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00663-5"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.008"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031317"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02713-X"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Logemann J: Evaluation and Treatment of Swallowing Disorders . Austin, TX, Pro-Ed Inc, 1998","DOI":"10.1097\/00020840-199812000-00008"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90013-O"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1007\/BF02407151"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.3.371"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02712-8"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00093-E"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970715)80:2<266::AID-CNCR15>3.0.CO;2-S"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.05.050"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh117"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.911"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.154.5.2108570"},{"key":"R20","unstructured":"Logemann J: Manual for the Videofluroscopic Study of Swallowing . Austin, TX, Pro-Ed Inc, 1993"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200004000-00008"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200308000-00023"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103013440908"},{"key":"R24","unstructured":"Chen A, Frankowski R, Bishop-Leone J, et al: The development and validation of a dysphagia-specific quality-of-life questionnaire for patients with head and neck cancer: The M.D. Anderson dysphagia inventory. Arch Otolaryngol Head Neck Surg 127:870,2001-876,"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2001.26492"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199910)21:7<595::AID-HED2>3.0.CO;2-J"},{"key":"R27","unstructured":"Murphy B, Smith K, Dowling E, et al: Baseline swallowing function for patients treated on E2399: A phase II trial of function preservation with induction paclitaxel\/carobplatin followed by radiation plus weekly paclitaxel. Proc Am Soc Clin Oncol 22:498,2003,  (suppl; abstr 2005)"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10255"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200007)22:4<393::AID-HED13>3.0.CO;2-2"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1177\/019459988509300114"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060507"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30242-5"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.012"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00404-8"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1177\/0115426502017004246"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20335"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.73.861.430"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1177\/014556130408300616"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1177\/014860710603000127"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.8.871"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1177\/0115426596011004157"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.1997.tb00268.x"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1177\/088453369701200112"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.10.1141"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.02.007"},{"key":"R46","doi-asserted-by":"crossref","unstructured":"Maccabee D, Sheppard B: Prevention of percutaneous endoscopic gastrostomy stoma metastases in patients with active oropharyngeal malignancy. Surg Endosc 17:1678,2003,","DOI":"10.1007\/s00464-002-4553-2"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010501)91:9<1785::AID-CNCR1197>3.0.CO;2-1"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10279"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200408000-00008"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)01627-4"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000207424.62275.9d"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(01)00429-7"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820915)50:6<1042::AID-CNCR2820500604>3.0.CO;2-Y"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900315"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900812"},{"key":"R56","unstructured":"Lazarus C: Effects of radiation therapy and voluntary maneuvers on swallow function in head and neck cancer patients. Clin Commun Disord 3:11,1993-20,"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.3.384"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-002-0096-x"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01556-5"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.3.792"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053422"},{"key":"R62","unstructured":"Cmelak A, Sigui L, Murphy B, et al: Locally advanced larynx or oropharynx cancer: Updated results of organ preservation trial E2399. J Clin Oncol  (in press)"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199609000-00021"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(200003)22:2<120::AID-HED3>3.0.CO;2-U"},{"key":"R65","doi-asserted-by":"crossref","unstructured":"Waters T, Logemann J, Pauloski B, et al: Beyond efficacy and effectiveness: Conducting economic analyses during clinical trials. Dysphagia 19:109,2004-119,","DOI":"10.1007\/s00455-003-0507-7"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90332-E"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10379"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.197.3.7480771"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)00028-6"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.08.004"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00421-G"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199705)19:3<169::AID-HED1>3.0.CO;2-0"},{"key":"R73","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90104-X"},{"key":"R74","doi-asserted-by":"crossref","unstructured":"Sonis S: Is oral mucositis an inevitable consequence of intensive therapy for hematologic cancers? Nat Clin Pract Oncol 2:134,2005-135,","DOI":"10.1038\/ncponc0104"},{"key":"R75","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660S107"},{"key":"R76","doi-asserted-by":"publisher","DOI":"10.1177\/08959374000140011601"},{"key":"R77","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001201)89:11<2258::AID-CNCR14>3.0.CO;2-Z"},{"key":"R78","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01512-7"},{"key":"R79","doi-asserted-by":"crossref","unstructured":"Brizel D, Wasserman T, Henke M, et al: Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol 18: 2000","DOI":"10.1200\/JCO.2000.18.19.3339"},{"key":"R80","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10365"},{"key":"R81","unstructured":"Franzmann E, Lundy D, Abitbol A, et al: Complete hypopharyngeal obstruction by mucosal adhesions: A complication of intensive chemoradiation for advanced head and neck cancer. Head Neck  (in press)"},{"key":"R82","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)01454-8"},{"key":"R83","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199709)19:6<535::AID-HED11>3.0.CO;2-4"},{"key":"R84","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90391-0"},{"key":"R85","unstructured":"Logemann J, Pauloski B, Rademaker A, et al: Speech and swallowing rehabilitation for head and neck cancer patients. Oncology (Williston Park) 11:651,1997-656, 659, 663-64,"},{"key":"R86","doi-asserted-by":"crossref","unstructured":"Shaker R, Kern M, Bardan E, et al: Augmentation of deglutitve, upper esophageal sphincter opening in the elderly by exercise. Am J Physiol 272:G1518,1997-G1522,","DOI":"10.1152\/ajpgi.1997.272.6.G1518"},{"key":"R87","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-001-0097-1"},{"key":"R88","unstructured":"Colton R, Casper J: Understanding voice problems: A physiological perspective for diagnosis and treatment, in Vocal Rehabilitation . Baltimore, MD, Lippincott, Williams, and Wilkins, pp 293,1996-294"},{"key":"R89","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0501.23"},{"key":"R90","unstructured":"Logemann J: Management of the Patient With Oropharyngeal Swallowing Disorders: Evaluation and Treatment of Swallowing Disorders . Austin, TX, Pro-Ed Inc, 1998"},{"key":"R91","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(97)01944-0"},{"key":"R92","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(97)00079-0"},{"key":"R93","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(00)00139-0"},{"key":"R94","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.12.060"},{"key":"R95","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01544-9"},{"key":"R96","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)03819-1"},{"key":"R97","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2715"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2006.06.0079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T21:20:25Z","timestamp":1653513625000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2006.06.0079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,10]]},"references-count":96,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2006,6,10]]}},"alternative-id":["10.1200\/JCO.2006.06.0079"],"URL":"https:\/\/doi.org\/10.1200\/jco.2006.06.0079","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,10]]}}}