{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:18:53Z","timestamp":1791314333617,"version":"4.3.1"},"reference-count":29,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2006,10,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> In adult T-lymphoblastic leukemia (T-ALL) disease-free survival remains limited to 32% to 46%. The adverse prognosis in T-ALL has not been attributed to cytogenetic or molecular aberrations. We have determined the prognostic impact of the oncogenic transcription factor ERG in T-ALL. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> ERG expression was analyzed by real-time polymerase chain reaction (PCR) in 105 adults with newly diagnosed T-ALL treated on the German ALL protocols. Patients were dichotomized at ERG\u2032s median expression into low (n = 52) and high (n = 53) expressers. Homeobox (HOX) 11 and HOX11L2 expression was determined by real-time PCR. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> High ERG expressers compared with low ERG expressers had an inferior overall survival (OS, P = .02; 5-year OS: high ERG 26% v low ERG 58%) and relapse-free survival (RFS, P = .003; 5-year RFS: high ERG 34% v low ERG 72%). On multivariable analysis high ERG expression (P = .005), immunophenotypic subgroups (early v mature v thymic T-ALL; overall P = .04), HOX11L2 positivity (P = .055), and absence of HOX11 (P = .017) were independent adverse risk factors predicting RFS. Patients with high ERG expression had a hazard ratio (HR) for relapse of 3.2. Within the good prognostic subgroup of thymic T-ALL (n = 57), high ERG (HR, 4.1; P = .02) and presence of HOX11L2 (HR, 6.6; P = .008) were independent adverse factors for RFS. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> High expression of ERG is an adverse risk factor in adult T-ALL. Within thymic T-ALL, otherwise classified as standard-risk, high ERG expression-identified patients that were four times more likely to fail long-term RFS. The prognostic impact of ERG may assist treatment stratification and suggest the need of alternative regimens. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2006.06.1580","type":"journal-article","created":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T03:45:22Z","timestamp":1157514322000},"page":"4714-4720","source":"Crossref","is-referenced-by-count":97,"title":["High Expression of the ETS Transcription Factor <i>ERG<\/i> Predicts Adverse Outcome in Acute T-Lymphoblastic Leukemia in Adults"],"prefix":"10.1200","volume":"24","author":[{"given":"Claudia D.","family":"Baldus","sequence":"first","affiliation":[{"name":"From the Department of Hematology, Oncology, and Transfusion Medicine; Department of Biostatistics and Clinical Epidemiology, Charit\u00e9, Campus Benjamin Franklin Berlin, University Hospital, Berlin; Department of Hematology and Oncology, University of Frankfurt am Main, Frankfurt, Germany; and Ohio State University, Comprehensive Cancer Center, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Burmeister","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Oncology, and Transfusion Medicine; Department of Biostatistics and Clinical Epidemiology, Charit\u00e9, Campus Benjamin Franklin Berlin, University Hospital, Berlin; Department of Hematology and Oncology, University of Frankfurt am Main, Frankfurt, Germany; and Ohio State University, Comprehensive Cancer Center, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Martus","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Oncology, and Transfusion Medicine; Department of Biostatistics and Clinical Epidemiology, Charit\u00e9, Campus Benjamin Franklin Berlin, University Hospital, Berlin; Department of Hematology and Oncology, University of Frankfurt am Main, Frankfurt, Germany; and Ohio State University, Comprehensive Cancer Center, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwartz","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Oncology, and Transfusion Medicine; Department of Biostatistics and Clinical Epidemiology, Charit\u00e9, Campus Benjamin Franklin Berlin, University Hospital, Berlin; Department of Hematology and Oncology, University of Frankfurt am Main, Frankfurt, Germany; and Ohio State University, Comprehensive Cancer Center, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"G\u00f6kbuget","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Oncology, and Transfusion Medicine; Department of Biostatistics and Clinical Epidemiology, Charit\u00e9, Campus Benjamin Franklin Berlin, University Hospital, Berlin; Department of Hematology and Oncology, University of Frankfurt am Main, Frankfurt, Germany; and Ohio State University, Comprehensive Cancer Center, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara D.","family":"Bloomfield","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Oncology, and Transfusion Medicine; Department of Biostatistics and Clinical Epidemiology, Charit\u00e9, Campus Benjamin Franklin Berlin, University Hospital, Berlin; Department of Hematology and Oncology, University of Frankfurt am Main, Frankfurt, Germany; and Ohio State University, Comprehensive Cancer Center, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Hoelzer","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Oncology, and Transfusion Medicine; Department of Biostatistics and Clinical Epidemiology, Charit\u00e9, Campus Benjamin Franklin Berlin, University Hospital, Berlin; Department of Hematology and Oncology, University of Frankfurt am Main, Frankfurt, Germany; and Ohio State University, Comprehensive Cancer Center, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard","family":"Thiel","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Oncology, and Transfusion Medicine; Department of Biostatistics and Clinical Epidemiology, Charit\u00e9, Campus Benjamin Franklin Berlin, University Hospital, Berlin; Department of Hematology and Oncology, University of Frankfurt am Main, Frankfurt, Germany; and Ohio State University, Comprehensive Cancer Center, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf K.","family":"Hofmann","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Oncology, and Transfusion Medicine; Department of Biostatistics and Clinical Epidemiology, Charit\u00e9, Campus Benjamin Franklin Berlin, University Hospital, Berlin; Department of Hematology and Oncology, University of Frankfurt am Main, Frankfurt, Germany; and Ohio State University, Comprehensive Cancer Center, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2004.22.14_suppl.4075"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Hoelzer D, Goekbuget N, Ottmann O, et al: Acute lymphoblastic leukemia. Am Soc Hematol Educ Program 1:162,2002-192,","DOI":"10.1182\/asheducation-2002.1.162"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-0734.2002.00068.x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.047"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5340.1059"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3900"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-11-0093"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204039"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Anderson MK, Hernandez-Hoyos G, Diamond RA, et al: Precise developmental regulation of ETS family transcription factors during specification and commitment to the T cell lineage. Development 126:3131,1999-3148,","DOI":"10.1242\/dev.126.14.3131"},{"key":"R10","unstructured":"Kong XT, Ida K, Ichikawa H, et al: Consistent detection of TLS\/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript. Blood 90:1192,1997-1199,"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400272101"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.6137"},{"key":"R13","unstructured":"Hoelzer D, Arnold R, Buechner T, et al: Characteristics, outcome and risk factors in adult T-lineage acute lymphoblastic leukemia (ALL). Blood 94:659a,1999,  (abstr 2926)"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2708"},{"key":"R15","unstructured":"Bene MC, Castoldi G, Knapp W, et al: Proposals for the immunological classification of acute leukemias. Leukemia 9:1783,1995-1786,"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402989"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Baak U, Goekbuget N, Burmeister T, et al: HOX11L2 genotyping identifies subset of adult thymic T-ALL with inferior outcome. Blood 106:70,2005,  (abstr 228)","DOI":"10.1182\/blood.V106.11.228.228"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000149608.29685.d1"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.5.1247.1247"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00018-1"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15542-6"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000143965.90813.70"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102160"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3666"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.4944"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3243"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1495"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403834"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402289"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2006.06.1580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T21:21:13Z","timestamp":1653513673000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2006.06.1580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,10]]},"references-count":29,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2006,10,10]]}},"alternative-id":["10.1200\/JCO.2006.06.1580"],"URL":"https:\/\/doi.org\/10.1200\/jco.2006.06.1580","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,10]]}}}