{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:02:17Z","timestamp":1790488937350,"version":"4.1.0"},"reference-count":56,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"36","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2006,12,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The role of hematopoietic stem-cell transplantation (SCT) in first complete remission (CR1) for children with very high\u2013risk (VHR) acute lymphoblastic leukemia (ALL) is still under critical discussion. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> In the ALL\u2013Berlin-Frankfurt-M\u00fcnster (BFM) 90 and ALL-BFM 95 trials, 387 patients were eligible for SCT if there was a matched sibling donor (MSD). T-cell ALL (T-ALL) patients with poor in vivo response to initial treatment represented the largest homogeneous subgroup within VHR patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Of 191 high-risk (HR) T-ALL patients, 179 patients (94%) achieved CR1. Twenty-three patients received an MSD-SCT. Furthermore, in trial ALL-BFM 95, eight matched unrelated donors (MUDs) and five mismatched family donors (MMFDs) were used. The median time to SCT was 5 months (range, 2.4 to 10.8 months) from diagnosis. The 5-year disease-free survival (DFS) was 67% \u00b1 8% for 36 patients who received an SCT in CR1 and 42% \u00b1 5% for the 120 patients treated with chemotherapy alone having an event-free survival time of at least the median time to transplantation (Mantel-Byar, P = .01). Overall survival (OS) rate for the SCT group was 67% \u00b1 8% at 5 years, whereas patients treated with chemotherapy alone had an OS rate of 47% \u00b1 5% at 5 years (Mantel-Byar, P = .01). Outcome of patients who received MSD-SCT versus MUD-\/MMFD-SCT was comparable (DFS, 65% \u00b1 10% v 69% \u00b1 13%, respectively). However, relapses only occurred after MSD-SCT (eight of 23 patients), whereas treatment-related mortality only occurred after MUD-\/MMFD-SCT (four of 13 patients). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> SCT in CR1 is superior to treatment with chemotherapy alone for childhood HR-T-ALL. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2006.06.2679","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T23:23:22Z","timestamp":1166484202000},"page":"5742-5749","source":"Crossref","is-referenced-by-count":103,"title":["Superiority of Allogeneic Hematopoietic Stem-Cell Transplantation Compared With Chemotherapy Alone in High-Risk Childhood T-Cell Acute Lymphoblastic Leukemia: Results From ALL-BFM 90 and 95"],"prefix":"10.1200","volume":"24","author":[{"given":"Andr\u00e9","family":"Schrauder","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel; Department of Pediatric Hematology and Oncology, Justus-Liebig University, Gie\u03b2en; Department of Pediatric Hematology and Oncology, University Hospital, T\u00fcbingen; Department of Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt; Department of Pediatric Hematology and Oncology, University Hospital, Essen; Department of General Pediatrics and Bone Marrow Transplantation, Charit\u00e9,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Reiter","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel; Department of Pediatric Hematology and Oncology, Justus-Liebig University, Gie\u03b2en; Department of Pediatric Hematology and Oncology, University Hospital, T\u00fcbingen; Department of Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt; Department of Pediatric Hematology and Oncology, University Hospital, Essen; Department of General Pediatrics and Bone Marrow Transplantation, Charit\u00e9,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Gadner","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel; Department of Pediatric Hematology and Oncology, Justus-Liebig University, Gie\u03b2en; Department of Pediatric Hematology and Oncology, University Hospital, T\u00fcbingen; Department of Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt; Department of Pediatric Hematology and Oncology, University Hospital, Essen; Department of General Pediatrics and Bone Marrow Transplantation, Charit\u00e9,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"Niethammer","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel; Department of Pediatric Hematology and Oncology, Justus-Liebig University, Gie\u03b2en; Department of Pediatric Hematology and Oncology, University Hospital, T\u00fcbingen; Department of Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt; Department of Pediatric Hematology and Oncology, University Hospital, Essen; Department of General Pediatrics and Bone Marrow Transplantation, Charit\u00e9,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klingebiel","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel; Department of Pediatric Hematology and Oncology, Justus-Liebig University, Gie\u03b2en; Department of Pediatric Hematology and Oncology, University Hospital, T\u00fcbingen; Department of Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt; Department of Pediatric Hematology and Oncology, University Hospital, Essen; Department of General Pediatrics and Bone Marrow Transplantation, Charit\u00e9,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Kremens","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel; Department of Pediatric Hematology and Oncology, Justus-Liebig University, Gie\u03b2en; Department of Pediatric Hematology and Oncology, University Hospital, T\u00fcbingen; Department of Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt; Department of Pediatric Hematology and Oncology, University Hospital, Essen; Department of General Pediatrics and Bone Marrow Transplantation, Charit\u00e9,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Peters","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel; Department of Pediatric Hematology and Oncology, Justus-Liebig University, Gie\u03b2en; Department of Pediatric Hematology and Oncology, University Hospital, T\u00fcbingen; Department of Pediatric Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt; Department of Pediatric Hematology and Oncology, University Hospital, Essen; 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