{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:01:59Z","timestamp":1791302519966,"version":"4.1.0"},"reference-count":31,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2006,11,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To examine the immune microenvironment in diagnostic follicular lymphoma (FL) biopsies and evaluate its prognostic significance. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Immunohistochemistry was used to study numbers and location of cells staining positive for immune cell markers CD4, CD7, CD8, CD25, CD68, forkhead box protein P3 (FOXP3), T-cell intracellular antigen-1, and Granzyme B in tissue microarrays of paraffin-embedded, diagnostic lymph node biopsies taken from 59 FL patients who lived less than 5 years (short-survival group; n = 34) and more than 15 years (long-survival group; n = 25). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> CD4 and FOXP3 expression were significantly different between the two groups. Samples from the long-survival group were more likely than those from the short-survival group to have CD4<jats:sup>+<\/jats:sup> staining cells and to have FOXP3-positive cells in a perifollicular location. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> This study has identified differences in immune cell composition of the diagnostic FL lymph node immune microenvironment and these have the potential for use as prognostic biomarkers in a routine histopathology setting. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2006.06.4642","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T02:57:42Z","timestamp":1160535462000},"page":"5052-5059","source":"Crossref","is-referenced-by-count":199,"title":["Number of CD4<sup>+<\/sup> Cells and Location of Forkhead Box Protein P3\u2013Positive Cells in Diagnostic Follicular Lymphoma Tissue Microarrays Correlates With Outcome"],"prefix":"10.1200","volume":"24","author":[{"given":"Abigail M.","family":"Lee","sequence":"first","affiliation":[{"name":"From the Cancer Research UK Medical Oncology Unit, St Bartholomew's Hospital, Charterhouse Square; and Department of Histopathology, St Bartholomew's Hospital, West Smithfield, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Clear","sequence":"additional","affiliation":[{"name":"From the Cancer Research UK Medical Oncology Unit, St Bartholomew's Hospital, Charterhouse Square; and Department of Histopathology, St Bartholomew's Hospital, West Smithfield, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Calaminici","sequence":"additional","affiliation":[{"name":"From the Cancer Research UK Medical Oncology Unit, St Bartholomew's Hospital, Charterhouse Square; and Department of Histopathology, St Bartholomew's Hospital, West Smithfield, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Davies","sequence":"additional","affiliation":[{"name":"From the Cancer Research UK Medical Oncology Unit, St Bartholomew's Hospital, Charterhouse Square; and Department of Histopathology, St Bartholomew's Hospital, West Smithfield, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Jordan","sequence":"additional","affiliation":[{"name":"From the Cancer Research UK Medical Oncology Unit, St Bartholomew's Hospital, Charterhouse Square; and Department of Histopathology, St Bartholomew's Hospital, West Smithfield, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finlay","family":"MacDougall","sequence":"additional","affiliation":[{"name":"From the Cancer Research UK Medical Oncology Unit, St Bartholomew's Hospital, Charterhouse Square; and Department of Histopathology, St Bartholomew's Hospital, West Smithfield, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Matthews","sequence":"additional","affiliation":[{"name":"From the Cancer Research UK Medical Oncology Unit, St Bartholomew's Hospital, Charterhouse Square; and Department of Histopathology, St Bartholomew's Hospital, West Smithfield, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Norton","sequence":"additional","affiliation":[{"name":"From the Cancer Research UK Medical Oncology Unit, St Bartholomew's Hospital, Charterhouse Square; and Department of Histopathology, St Bartholomew's Hospital, West Smithfield, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Gribben","sequence":"additional","affiliation":[{"name":"From the Cancer Research UK Medical Oncology Unit, St Bartholomew's Hospital, Charterhouse Square; and Department of Histopathology, St Bartholomew's Hospital, West Smithfield, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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