{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:43:21Z","timestamp":1761155001236},"reference-count":29,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2007,3,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To investigate the association between physical activity, body mass index (BMI), and mammographic density in a racially\/ethnically diverse population-based sample of 522 postmenopausal women diagnosed with stage 0-IIIA breast cancer and enrolled in the Health, Eating, Activity, and Lifestyle Study. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We collected information on BMI and physical activity during a clinic visit 2 to 3 years after diagnosis. Weight and height were measured in a standard manner. Using an interview-administered questionnaire, participants recalled the type, duration, and frequency of physical activities they had performed in the last year. We estimated dense area and percentage density as a continuous measure using a computer-assisted software program from mammograms imaged approximately 1 to 2 years after diagnosis. Analysis of covariance methods were used to obtain mean density across WHO BMI categories and physical activity tertiles adjusted for confounders. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> We observed a statistically significant decline in percentage density (P for trend = .0001), and mammographic dense area (P for trend = .0052), with increasing level of BMI adjusted for potential covariates. We observed a statistically significant decline in mammographic dense area (P for trend = .036) with increasing level of sports\/recreational physical activity in women with a BMI of at least 30 kg\/m<jats:sup>2<\/jats:sup>. Conversely, in women with a BMI less than 25 kg\/m<jats:sup>2<\/jats:sup>, we observed a non\u2013statistically significant increase in mammographic dense area and percentage density with increasing level of sports\/recreational physical activity. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Increasing physical activity among obese postmenopausal breast cancer survivors may be a reasonable intervention approach to reduce mammographic density. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2006.07.3965","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T18:29:01Z","timestamp":1170440941000},"page":"1061-1066","source":"Crossref","is-referenced-by-count":57,"title":["Physical Activity, Body Mass Index, and Mammographic Density in Postmenopausal Breast Cancer Survivors"],"prefix":"10.1200","volume":"25","author":[{"given":"Melinda L.","family":"Irwin","sequence":"first","affiliation":[{"name":"From the Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT; Center for Health Studies, Group Health Cooperative; Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Preventive Medicine, University of Southern California, Los Angeles, CA; Cancer Research & Treatment Center, Department of Internal Medicine, University of New Mexico, Albuquerque, NM; and the Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin J.","family":"Aiello","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT; Center for Health Studies, Group Health Cooperative; Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Preventive Medicine, University of Southern California, Los Angeles, CA; Cancer Research & Treatment Center, Department of Internal Medicine, University of New Mexico, Albuquerque, NM; and the Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"McTiernan","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT; Center for Health Studies, Group Health Cooperative; Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Preventive Medicine, University of Southern California, Los Angeles, CA; Cancer Research & Treatment Center, Department of Internal Medicine, University of New Mexico, Albuquerque, NM; and the Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Bernstein","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT; Center for Health Studies, Group Health Cooperative; Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Preventive Medicine, University of Southern California, Los Angeles, CA; Cancer Research & Treatment Center, Department of Internal Medicine, University of New Mexico, Albuquerque, NM; and the Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank D.","family":"Gilliland","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT; Center for Health Studies, Group Health Cooperative; Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Preventive Medicine, University of Southern California, Los Angeles, CA; Cancer Research & Treatment Center, Department of Internal Medicine, University of New Mexico, Albuquerque, NM; and the Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard N.","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT; Center for Health Studies, Group Health Cooperative; Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Preventive Medicine, University of Southern California, Los Angeles, CA; Cancer Research & Treatment Center, Department of Internal Medicine, University of New Mexico, Albuquerque, NM; and the Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy B.","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT; Center for Health Studies, Group Health Cooperative; Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Preventive Medicine, University of Southern California, Los Angeles, CA; Cancer Research & Treatment Center, Department of Internal Medicine, University of New Mexico, Albuquerque, NM; and the Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Ballard-Barbash","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT; Center for Health Studies, Group Health Cooperative; Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Preventive Medicine, University of Southern California, Los Angeles, CA; Cancer Research & Treatment Center, Department of Internal Medicine, University of New Mexico, Albuquerque, NM; and the Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70390-9"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0327"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh260"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0798"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2005.02.010"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh106"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.7.488"},{"key":"R8","unstructured":"Berglund G: Anthropometry, physical activity and cancer of the breast and colon. IARC Sci Publ 156:237,2002-241,"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3393"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-005-9063-1"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11227"},{"key":"R12","unstructured":"Irwin ML, McTiernan A, Bernstein L, Gilliland G, et al: Physical activity levels among breast cancer survivors. Med Sci Sports Exer 36:1484,2004-1491,"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.07.057"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1998.tb00690.x"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199706001-00015"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200009001-00009"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.9.670"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.20.2479"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.4.1128"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008926607428"},{"key":"R21","unstructured":"Gram IT, Funkhouser E, Tabar L: Moderate physical activity in relation to mammographic patterns. Cancer Epidemiol Biomarkers Prev 8:117,1999-122,"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0569"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi286"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600537"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0920"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.6.443"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.11.756"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11517"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1118\/1.1539038"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2006.07.3965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T21:17:14Z","timestamp":1653513434000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2006.07.3965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,20]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,3,20]]}},"alternative-id":["10.1200\/JCO.2006.07.3965"],"URL":"https:\/\/doi.org\/10.1200\/jco.2006.07.3965","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,20]]}}}