{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:58:05Z","timestamp":1790762285919,"version":"4.1.0"},"reference-count":34,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"33","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2006,11,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Some diffuse large B-cell lymphomas (DLBCL) present at diagnosis with associated morphologic features of small B-cell non-Hodgkin's lymphoma (NHL) and may arise from the transformation of a previously unknown indolent low-grade lymphoma. The characteristics and prognosis of these particular DLBCL are not well known. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> The strict morphologic review of consecutive DLBCL patients diagnosed over 12 years in our department (Hematology Department, Centre Hospitalier Lyon-Sud, Lyon, France) allowed to retrieve 60 DLBCL that could be have occurred from the transformation of marginal zone B-cell NHL (32 patients), follicular NHL (22 patients), and small lymphocytic NHL (6 patients). We compared them to 180 matched patients of de novo DLBCL. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Patients median age was 55 years and presented the following clinical characteristics: poor performance status in 33%, disseminated disease in 97%, more than one extranodal site in 50%, and increased lactate dehydrogenase level in 55%. Complete remission with multidrug chemotherapy regimens was achieved in 60% of the patients, but 48% relapsed: 28% with aggressive and 20% with indolent histology, respectively. Overall survival (OS) and freedom-from-progression rates at 5 years were 57% and 33%, respectively. The matched-control analysis showed that patients with transformed NHL at diagnosis had lower complete response to chemotherapy (P = .004) and higher progression rate (P = .03), whereas no difference was observed in OS (P = .21). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Compared to de novo DLBCL, transformed NHL at diagnosis have similar overall survival but lower complete response to initial treatment and higher risk of indolent relapses. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2006.07.5671","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T12:10:23Z","timestamp":1161087023000},"page":"5234-5241","source":"Crossref","is-referenced-by-count":67,"title":["Clinicopathologic Characteristics and Outcome of Diffuse Large B-Cell Lymphomas Presenting With an Associated Low-Grade Component at Diagnosis"],"prefix":"10.1200","volume":"24","author":[{"given":"Herv\u00e9","family":"Ghesqui\u00e8res","sequence":"first","affiliation":[{"name":"From the Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Service d'H\u00e9matologie, Service d'Anatomie Pathologique, and Laboratoire d'H\u00e9matologie; Equipe d'Accueil, Pathologie des Cellules Lympho\u00efdes, Universit\u00e9 Claude Bernard, Pierre-B\u00e9nite; Laboratoire d'H\u00e9matologie, H\u00f4pital E. Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Berger","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Service d'H\u00e9matologie, Service d'Anatomie Pathologique, and Laboratoire d'H\u00e9matologie; Equipe d'Accueil, Pathologie des Cellules Lympho\u00efdes, Universit\u00e9 Claude Bernard, Pierre-B\u00e9nite; Laboratoire d'H\u00e9matologie, H\u00f4pital E. Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Felman","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Service d'H\u00e9matologie, Service d'Anatomie Pathologique, and Laboratoire d'H\u00e9matologie; Equipe d'Accueil, Pathologie des Cellules Lympho\u00efdes, Universit\u00e9 Claude Bernard, Pierre-B\u00e9nite; Laboratoire d'H\u00e9matologie, H\u00f4pital E. 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