{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:56:38Z","timestamp":1791233798610,"version":"4.1.0"},"reference-count":34,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2007,5,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Approximately 15% of patients with localized and 30% with disseminated classical Hodgkin's lymphoma fail to respond or relapse after first-line treatment. Usual prognosis scoring systems are actually unable to identify this small subset of patients with good confidence, pointing out the need for additional prognostic biomarkers. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> We prospectively analyzed the prognosis value of plasma levels of tumor necrosis factor (TNF), its soluble receptors TNF-R1 and TNF-R2, IL-10, IL1-RA, IL-6, and soluble CD30 (sCD30) when taken before any treatment in 519 consecutive patients with a first diagnosis of classical Hodgkin's lymphoma. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Levels of TNF\u03b1 higher than 46 pg\/mL, TNF-R1 higher than 3 ng\/mL, TNF-R2 higher than 5 ng\/mL, IL-10 higher than 30 pg\/mL, IL1-RA higher than 668 pg\/mL, IL-6 higher than 30 pg\/mL, and sCD30 higher than 80 U\/mL were associated with poor event-free and overall survival. In multivariate analysis, high levels of IL1-RA, IL-6, and sCD30 were independent poor prognosis factors, and the cytokine signature based on their combination allowed the stratification of patients in four prognosis classes, reaching a 5-year event-free survival probability of 92%, 85%, 76%, and 15%, respectively. This index was more potent than other scoring systems to predict patient event-free survival, and remained independent from the international prognostic score (P &lt; .001), adding significant prognostic information to its predictive power. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Plasma cytokine signature is sufficient to predict disease-related outcome in classical Hodgkin's lymphoma, and allows the identification of patients with very high risk of treatment failure. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2006.08.1331","type":"journal-article","created":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T03:41:38Z","timestamp":1175053298000},"page":"1732-1740","source":"Crossref","is-referenced-by-count":101,"title":["Plasma Cytokine and Soluble Receptor Signature Predicts Outcome of Patients With Classical Hodgkin's Lymphoma: A Study From the Groupe d'Etude des Lymphomes de l'Adulte"],"prefix":"10.1200","volume":"25","author":[{"given":"Ren\u00e9-Olivier","family":"Casasnovas","sequence":"first","affiliation":[{"name":"From the H\u00f4pital Le Bocage, Dijon; H\u00f4pital St-Louis; H\u00f4pital Piti\u00e9 Salp\u00e9tri\u00e8re, Paris; H\u00f4pital Henri Mondor, Cr\u00e9teil; Centre Hospitalier Universitaire (CHU) Lille, Lille; Centre L\u00e9on B\u00e9rard, Lyon; H\u00f4pital Jean Minjoz, Besan\u00e7on; CHU Nancy, Nancy; Centre Henri Becquerel, Rouen; Hospices Civils de Lyon and Universit\u00e9 Claude Bernard, Lyon; Institut Gustave Roussy, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Mounier","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Le Bocage, Dijon; H\u00f4pital St-Louis; H\u00f4pital Piti\u00e9 Salp\u00e9tri\u00e8re, Paris; H\u00f4pital Henri Mondor, Cr\u00e9teil; Centre Hospitalier Universitaire (CHU) Lille, Lille; Centre L\u00e9on B\u00e9rard, Lyon; H\u00f4pital Jean Minjoz, Besan\u00e7on; CHU Nancy, Nancy; Centre Henri Becquerel, Rouen; Hospices Civils de Lyon and Universit\u00e9 Claude Bernard, Lyon; Institut Gustave Roussy, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Brice","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Le Bocage, Dijon; 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