{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:21:52Z","timestamp":1790907712695,"version":"4.1.0"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2007,8,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To determine the optimal injection path for blue dye and radiocolloid for sentinel lymph node (SLN) biopsy in early breast cancer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> A prospective randomized multicentric study was initiated to compare the peritumoral (PT) injection site to the periareolar (PA) site in 449 patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The detection rate of axillary SLN by lymphoscintigraphy was significantly higher (P = .03) in the PA group (85.2%) than in the PT group (73.2%). Intraoperative detection rate by blue dye and\/or gamma probe was similar (99.11%) in both groups. The rate of SLN detection was somewhat higher in the PA group than in the PT group: 95.6% versus 93.8% with blue dye (P = .24) and 98.2% versus 96.0% by probe (P = .16), respectively. The number of SLNs detected by lymphoscintigraphy and by probe was significantly higher in the PA group than in the PT group, 1.5 versus 1.2 (P = .001) and 1.9 versus 1.7 (P = .02). The blue and hot concordance was 95.6% in the PA group and 91.5% in the PT group (P = .08). The mean ex vivo count of the SLN was significantly higher in the PA group than in the PT group (P &lt; .0001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> This study strongly validates the PA injection technique given the high detection rate (99.1%) of SLN and the high concordance (95.6%) between blue dye and the radiotracer, as well as higher significant ex and in vivo counts, improving SLN probe detection. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2006.08.4228","type":"journal-article","created":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T00:40:56Z","timestamp":1178584856000},"page":"3664-3669","source":"Crossref","is-referenced-by-count":111,"title":["Prospective Multicentric Randomized Study Comparing Periareolar and Peritumoral Injection of Radiotracer and Blue Dye for the Detection of Sentinel Lymph Node in Breast Sparing Procedures: FRANSENODE Trial"],"prefix":"10.1200","volume":"25","author":[{"given":"Jean-Fran\u00e7ois","family":"Rodier","sequence":"first","affiliation":[{"name":"From the French Comprehensive Cancer Centers of Strasbourg, Toulouse, Lyon, Nantes, Bordeaux, Angers, and Marseille; Axium Clinic of Aix en Provence; Community Hospital of Le Mans; and the Community Hospital of Orl\u00e9ans, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Velten","sequence":"additional","affiliation":[{"name":"From the French Comprehensive Cancer Centers of Strasbourg, Toulouse, Lyon, Nantes, Bordeaux, Angers, and Marseille; Axium Clinic of Aix en Provence; Community Hospital of Le Mans; and the Community Hospital of Orl\u00e9ans, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Wilt","sequence":"additional","affiliation":[{"name":"From the French Comprehensive Cancer Centers of Strasbourg, Toulouse, Lyon, Nantes, Bordeaux, Angers, and Marseille; Axium Clinic of Aix en Provence; Community Hospital of Le Mans; and the Community Hospital of Orl\u00e9ans, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Martel","sequence":"additional","affiliation":[{"name":"From the French Comprehensive Cancer Centers of Strasbourg, Toulouse, Lyon, Nantes, Bordeaux, Angers, and Marseille; 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