{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:34:40Z","timestamp":1790652880264,"version":"4.1.0"},"reference-count":44,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2007,8,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Childhood cancer survivors treated with anthracyclines and cardiac radiation are at risk for late-onset cardiotoxicity. The purpose of this study was to delineate the relationship between clinical factors and abnormalities of noninvasive cardiac testing (NICT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Participants were recruited from a long-term follow-up clinic. Study measures comprised physical examination, laboratory evaluation, echocardiogram, and ECG. Mean fractional shortening (FS) and afterload were compared for survivors who did (at risk [AR]) and did not (no risk [NR]) receive potentially cardiotoxic modalities, and with values expected for comparable age- and sex-matched controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The 278 study participants (mean age, 18.1 years; median age, 16.8 years; range, 7.5 to 39.7 years) included 223 survivors AR for cardiotoxicity after treatment with anthracyclines (median dose \u00b1 standard deviation [SD], 202 \u00b1 109 mg\/m<jats:sup>2<\/jats:sup>) and\/or cardiac radiation. Mean FS (\u00b1 SD) was lower for AR (0.33 \u00b1 0.06) compared with NR survivors (0.36 \u00b1 0.05; P = .004) and normative controls (0.36 \u00b1 0.04; P &lt; .001). Mean afterload (\u00b1 SD) was higher for AR (58 \u00b1 21 g\/cm<jats:sup>2<\/jats:sup>) compared with NR survivors (46 \u00b1 15 g\/cm<jats:sup>2<\/jats:sup>; P &lt; .001) and normative controls (48 \u00b1 13 g\/cm<jats:sup>2<\/jats:sup>; P &lt; .001). The distribution of FS and afterload among NR survivors did not differ from that of controls. After adjustment for age group at diagnosis and time since completion of therapy, anthracycline dose predicted decline in distribution of FS (P &lt; .001) and increase in distribution of afterload (P &lt; .001). Treatment with anthracycline doses \u2265 100 mg\/m<jats:sup>2<\/jats:sup> increased the risk of abnormal NICT; survivors who received \u2265 270 mg\/m<jats:sup>2<\/jats:sup> had a 4.5-fold excess risk of abnormal NICT (95% CI, 2.1 to 9.6) compared with controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Childhood cancer survivors treated with anthracycline doses \u2265 270 mg\/m<jats:sup>2<\/jats:sup> are at greatest risk for abnormalities of FS and afterload. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2006.09.7451","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T22:23:29Z","timestamp":1187389409000},"page":"3635-3643","source":"Crossref","is-referenced-by-count":109,"title":["Noninvasive Evaluation of Late Anthracycline Cardiac Toxicity in Childhood Cancer Survivors"],"prefix":"10.1200","volume":"25","author":[{"given":"Melissa M.","family":"Hudson","sequence":"first","affiliation":[{"name":"From the Departments of Hematology Oncology, Biostatistics, Radiological Sciences, and Epidemiology and Cancer Control, and the Division of Behavioral Medicine, St Jude Children's Research Hospital, the University of Tennessee, College of Medicine, Memphis, TN; Department of Pediatrics, M.D. Anderson Cancer Center, Houston, TX; Department of Pediatrics and Cardiology, Stanford University Medical Center, Stanford; and Department of Surgical Education, Santa Barbara Cottage Hospital, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shesh N.","family":"Rai","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology Oncology, Biostatistics, Radiological Sciences, and Epidemiology and Cancer Control, and the Division of Behavioral Medicine, St Jude Children's Research Hospital, the University of Tennessee, College of Medicine, Memphis, TN; Department of Pediatrics, M.D. Anderson Cancer Center, Houston, TX; Department of Pediatrics and Cardiology, Stanford University Medical Center, Stanford; and Department of Surgical Education, Santa Barbara Cottage Hospital, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Nunez","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology Oncology, Biostatistics, Radiological Sciences, and Epidemiology and Cancer Control, and the Division of Behavioral Medicine, St Jude Children's Research Hospital, the University of Tennessee, College of Medicine, Memphis, TN; Department of Pediatrics, M.D. Anderson Cancer Center, Houston, TX; Department of Pediatrics and Cardiology, Stanford University Medical Center, Stanford; and Department of Surgical Education, Santa Barbara Cottage Hospital, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Merchant","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology Oncology, Biostatistics, Radiological Sciences, and Epidemiology and Cancer Control, and the Division of Behavioral Medicine, St Jude Children's Research Hospital, the University of Tennessee, College of Medicine, Memphis, TN; Department of Pediatrics, M.D. Anderson Cancer Center, Houston, TX; Department of Pediatrics and Cardiology, Stanford University Medical Center, Stanford; and Department of Surgical Education, Santa Barbara Cottage Hospital, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neyssa M.","family":"Marina","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology Oncology, Biostatistics, Radiological Sciences, and Epidemiology and Cancer Control, and the Division of Behavioral Medicine, St Jude Children's Research Hospital, the University of Tennessee, College of Medicine, Memphis, TN; Department of Pediatrics, M.D. Anderson Cancer Center, Houston, TX; Department of Pediatrics and Cardiology, Stanford University Medical Center, Stanford; and Department of Surgical Education, Santa Barbara Cottage Hospital, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nia","family":"Zalamea","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology Oncology, Biostatistics, Radiological Sciences, and Epidemiology and Cancer Control, and the Division of Behavioral Medicine, St Jude Children's Research Hospital, the University of Tennessee, College of Medicine, Memphis, TN; Department of Pediatrics, M.D. Anderson Cancer Center, Houston, TX; Department of Pediatrics and Cardiology, Stanford University Medical Center, Stanford; and Department of Surgical Education, Santa Barbara Cottage Hospital, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Cox","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology Oncology, Biostatistics, Radiological Sciences, and Epidemiology and Cancer Control, and the Division of Behavioral Medicine, St Jude Children's Research Hospital, the University of Tennessee, College of Medicine, Memphis, TN; Department of Pediatrics, M.D. Anderson Cancer Center, Houston, TX; Department of Pediatrics and Cardiology, Stanford University Medical Center, Stanford; and Department of Surgical Education, Santa Barbara Cottage Hospital, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Phipps","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology Oncology, Biostatistics, Radiological Sciences, and Epidemiology and Cancer Control, and the Division of Behavioral Medicine, St Jude Children's Research Hospital, the University of Tennessee, College of Medicine, Memphis, TN; Department of Pediatrics, M.D. Anderson Cancer Center, Houston, TX; Department of Pediatrics and Cardiology, Stanford University Medical Center, Stanford; and Department of Surgical Education, Santa Barbara Cottage Hospital, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Pompeu","sequence":"additional","affiliation":[{"name":"From the Departments of Hematology Oncology, Biostatistics, Radiological Sciences, and Epidemiology and Cancer Control, and the Division of Behavioral Medicine, St Jude Children's Research Hospital, the University of Tennessee, College of Medicine, Memphis, TN; 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