{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:43:21Z","timestamp":1778687001414,"version":"3.51.4"},"reference-count":50,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"30","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2007,10,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Smoking, obesity, and insulin resistance are well-known risk factors for cancer, yet few epidemiology studies evaluate their role as risk factors for a second primary cancer (SPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>We identified 14,181 men with a first cancer from the National Health Insurance Corporation Study cohort. We obtained data on fasting glucose level, body mass index (BMI), and smoking history from an enrollment interview (1996). We obtained SPC incidence data for 1996 through 2002 from the Korean Central Cancer Registry. We used the standard Poisson regression model to estimate the age- and multivariate-adjusted relative risk (RR) for SPCs in relation to smoking history, BMI, and insulin resistance before diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed 204 patients with SPC. The overall age-standardized incidence rate of SPC was 603.2 occurrences per 100,000 person-years, which was about 2.3 times higher than that of first cancer in the general male population. Multivariate regression revealed that lung (RR, 3.69; 95% CI, 1.35 to 10.09) and smoking-related (RR, 2.02; 95% CI, 1.02 to 4.03) SPCs were significantly associated with smoking. Obese patients (BMI \u2265 25 kg\/m<jats:sup>2<\/jats:sup>) had significantly elevated RRs for colorectal (RR, 3.45; 95% CI, 1.50 to 7.93) and genitourinary (RR, 3.61; 95% CI, 1.36 to 9.54) SPCs. Patients with a fasting serum glucose concentration \u2265 126 mg\/dL had a higher RR for hepatopancreatobiliary (RR, 3.33; 95% CI, 1.33 to 8.37) and smoking-related (1.93; 95% CI, 1.01 to 3.68) SPCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prediagnosis smoking history, obesity, and insulin resistance were risk factors for several SPCs. These findings suggest that more thorough surveillance and screening for SPCs is needed for the cancer survivors with these risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2006.10.3416","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T22:28:37Z","timestamp":1192746517000},"page":"4835-4843","source":"Crossref","is-referenced-by-count":86,"title":["Prediagnosis Smoking, Obesity, Insulin Resistance, and Second Primary Cancer Risk in Male Cancer Survivors: National Health Insurance Corporation Study"],"prefix":"10.1200","volume":"25","author":[{"given":"Sang","family":"Min Park","sequence":"first","affiliation":[{"name":"From the National Cancer Center, Goyang, Gyeonggi; National Health Insurance Corporation; and Department of Preventive Medicine and Department of Family Medicine, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Kyung Lim","sequence":"additional","affiliation":[{"name":"From the National Cancer Center, Goyang, Gyeonggi; National Health Insurance Corporation; and Department of Preventive Medicine and Department of Family Medicine, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu","family":"Won Jung","sequence":"additional","affiliation":[{"name":"From the National Cancer Center, Goyang, Gyeonggi; National Health Insurance Corporation; and Department of Preventive Medicine and Department of Family Medicine, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon","family":"Ae Shin","sequence":"additional","affiliation":[{"name":"From the National Cancer Center, Goyang, Gyeonggi; National Health Insurance Corporation; and Department of Preventive Medicine and Department of Family Medicine, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keun-Young","family":"Yoo","sequence":"additional","affiliation":[{"name":"From the National Cancer Center, Goyang, Gyeonggi; National Health Insurance Corporation; and Department of Preventive Medicine and Department of Family Medicine, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young","family":"Ho Yun","sequence":"additional","affiliation":[{"name":"From the National Cancer Center, Goyang, Gyeonggi; National Health Insurance Corporation; and Department of Preventive Medicine and Department of Family Medicine, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong","family":"Yul Huh","sequence":"additional","affiliation":[{"name":"From the National Cancer Center, Goyang, Gyeonggi; National Health Insurance Corporation; and Department of Preventive Medicine and Department of Family Medicine, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1317"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21051"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdp.2004.08.006"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0236"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000016573.79453.ba"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20529"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.11.726"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.194"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20013"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.1.67"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.0243"},{"key":"R15","unstructured":"Kahn HA: The Dorn study of smoking and mortality among US veterans: Report on eight and one-half years of observation. In: W. Haenszel (ed): Epidemiological Approaches to the Study of Cancer and Other Chronic Diseases, Vol 19. US Department of Health, Education, and Welfare, Rockville, MD. Natl Cancer Inst Monogr 1,1966-125,"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6959.901"},{"key":"R17","unstructured":"Pasanen PA, Eskelinen M, Partanen K, et al: Multivariate analysis of six serum tumor markers (CEA, CA 50, CA 242, TPA, TPS, TATI) and conventional laboratory tests in the diagnosis of hepatopancreatobiliary malignancy. Anticancer Res 15:2731,1995-2737,"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4805"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-003-0379-3"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)04613-8"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2002.34.6.405"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20272"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.12.074"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01665-0"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.12.2406"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.20.1530"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.2188\/jea.10.300"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023060315781"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4+<1872::AID-CNCR2820400817>3.0.CO;2-#"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.2.131"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.1.42"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11544"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.181"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023926401227"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000154352.54965.14"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1136\/jech.51.3.252"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.4.1128"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(90)90190-N"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.07.125"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0762"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.19.2552"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00241-5"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051090"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000091339.70120.53"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2003.08.016"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.01.008"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3631"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.1381"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji278"},{"key":"R52","doi-asserted-by":"crossref","unstructured":"Satia JA, Campbell MK, Galanko JA, et al: Longitudinal changes in lifestyle behaviors and health status in colon cancer survivors. Cancer Epidemiol Biomarkers Prev 13:1022,2004-1031,","DOI":"10.1158\/1055-9965.1022.13.6"},{"key":"R53","doi-asserted-by":"crossref","unstructured":"Patterson RE, Neuhouser ML, Hedderson MM, et al: Changes in diet, physical activity, and supplement use among adults diagnosed with cancer. J Am Diet Assoc 103:323,2003-328,","DOI":"10.1053\/jada.2003.50045"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.pubmed.a024744"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00533-6"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2006.10.3416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T12:44:41Z","timestamp":1684068281000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2006.10.3416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,20]]},"references-count":50,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2007,10,20]]}},"alternative-id":["10.1200\/JCO.2006.10.3416"],"URL":"https:\/\/doi.org\/10.1200\/jco.2006.10.3416","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,20]]}}}