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This article will review the rationale and efficacy of RRSO for prevention of breast and BRCA-associated gynecologic cancer. Surgical technique and methods of pathologic evaluation will be presented. Controversies regarding uterine preservation and post-RRSO hormone replacement therapy will be addressed. Considerations that may impact the appropriate timing of the procedure will be reviewed, and the potential role of RRSO in BRCA-negative hereditary breast cancer families will also be discussed. <\/jats:p>","DOI":"10.1200\/jco.2007.11.3449","type":"journal-article","created":{"date-parts":[[2007,7,6]],"date-time":"2007-07-06T22:28:33Z","timestamp":1183760913000},"page":"2921-2927","source":"Crossref","is-referenced-by-count":118,"title":["Risk-Reducing Salpingo-Oophorectomy in Patients With Germline Mutations in <i>BRCA1<\/i> or <i>BRCA2<\/i>"],"prefix":"10.1200","volume":"25","author":[{"given":"Noah D.","family":"Kauff","sequence":"first","affiliation":[{"name":"From the Gynecology Service, Department of Surgery, and Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Barakat","sequence":"additional","affiliation":[{"name":"From the Gynecology Service, Department of Surgery, and Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1086\/318787"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70476-4"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21536"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705153362001"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1086\/301749"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1086\/375033"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088759"},{"key":"R8","unstructured":"National Comprehensive Cancer Network: Clinical Practice Guidelines in Oncology, V. 1.2006. 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