{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:45:13Z","timestamp":1791305113525,"version":"4.3.1"},"reference-count":26,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"34","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Our previous phase II trial for treating human T-lymphotropic virus type I\u2013associated adult T-cell leukemia-lymphoma (ATLL) with vincristine, cyclophosphamide, doxorubicin, and prednisone (VCAP), doxorubicin, ranimustine, and prednisone (AMP), and vindesine, etoposide, carboplatin, and prednisone (VECP) showed promising results. To test the superiority of VCAP-AMP-VECP over biweekly cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), we conducted a randomized controlled trial exclusively for ATLL. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Previously untreated patients with aggressive ATLL were assigned to receive either six courses of VCAP-AMP-VECP every 4 weeks or eight courses of biweekly CHOP. Both treatments were supported with granulocyte colony-stimulating factor and intrathecal prophylaxis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> A total of 118 patients were enrolled. The complete response (CR) rate was higher in the VCAP-AMP-VECP arm than in biweekly CHOP arm (40% v 25%, respectively; P = .020). Progression-free survival rate at 1 year was 28% in the VCAP-AMP-VECP arm compared with 16% in the CHOP arm (P = .100, two-sided P = .200). Overall survival (OS) at 3 years was 24% in the VCAP-AMP-VECP arm and 13% in the CHOP arm (P = .085, two-sided P = .169). For VCAP-AMP-VECP versus biweekly CHOP, grade 4 neutropenia, grade 4 thrombocytopenia, and grade 3 or 4 infection rates were 98% v 83%, 74% v 17%, and 32% v 15%, respectively. There were three toxic deaths in the VCAP-AMP-VECP arm. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The longer OS at 3 years and higher CR rate with VCAP-AMP-VECP compared with biweekly CHOP suggest that VCAP-AMP-VECP might be a more effective regimen at the expense of higher toxicities, providing the basis for future investigations in the treatment of ATLL. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2007.11.9958","type":"journal-article","created":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T23:20:50Z","timestamp":1193700050000},"page":"5458-5464","source":"Crossref","is-referenced-by-count":444,"title":["VCAP-AMP-VECP Compared With Biweekly CHOP for Adult T-Cell Leukemia-Lymphoma: Japan Clinical Oncology Group Study JCOG9801"],"prefix":"10.1200","volume":"25","author":[{"given":"Kunihiro","family":"Tsukasaki","sequence":"first","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atae","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Fukuda","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Shibata","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Fukushima","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifusa","family":"Takatsuka","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Ikeda","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Masuda","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhisa","family":"Nagoshi","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuzo","family":"Ueda","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tamura","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Sano","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saburo","family":"Momita","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; Imamura Bun-in Hospital; Kagoshima University, Kagoshima; National Cancer Center Research Institute; National Cancer Center Hospital, Tokyo; Sasebo City General Hospital, Sasebo; Ryukyu University, Nishihara; St Marianna University, Yokohama; Nagoya City University; National Hospital Organization Nagoya Medical Center, Nagoya; Fukuoka University, Fukuoka; Saga University, Saga; National Hospital Organization Nagasaki Medical Center, Ohmura; Kumamoto University; and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"From the Nagasaki University, Nagasaki; 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