{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:53:58Z","timestamp":1791125638897,"version":"4.1.0"},"reference-count":73,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2008,3,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To identify prognostic factors and to evaluate the outcome of children with acute lymphoblastic leukemia (ALL) failure after induction therapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Between June 1993 and December 1999, 1,395 leukemic children were included in the French Acute Lymphoblastic Leukemia 93 study. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Fifty-three patients (3.8%) had a leukemic induction failure (LIF) after three- or four-drug induction therapy. In univariate analysis, high WBC count (P = .001), mediastinal mass (P = .017), T-cell phenotype (T-ALL; P = .001), t(9;22) translocation (P = .001), and a slow early response (at day 8 and\/or on day 21, P = .001) were predictive of LIF. The following three prognostic groups for LIF were identified by multivariate analysis: a low-risk group with B-cell progenitor (BCP) ALL without t(9;22) (odds ratio [OR] = 1), an intermediate-risk group with T-ALL and a mediastinal mass (OR = 7.4, P &lt; .0001), and a high-risk group with BCP-ALL and t(9;22) or T-ALL without a mediastinal mass (OR = 28.4, P &lt; .0001). Complete remission (CR) was subsequently obtained in 43 patients (81%). The 5-year overall survival (OS) rate of the 53 patients was 30% \u00b1 6%. The 5-year OS rate among allogeneic graft recipients, autologous graft recipients, and after chemotherapy were 30.4% \u00b1 9.6% (50% \u00b1 26% after genoidentical transplantation), 50% \u00b1 17.7%, and 41.7% \u00b1 14.2%, respectively (P = .18). Fourteen patients (26%) were still in first CR after a median of 83 months (range, 53 to 117 months). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Three risk categories for LIF in children with ALL were identified. Approximately one third of patients with LIF can be successfully treated with salvage therapy overall. Subsequent CR after LIF is mandatory for cure. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2007.12.2820","type":"journal-article","created":{"date-parts":[[2008,3,18]],"date-time":"2008-03-18T22:23:52Z","timestamp":1205879032000},"page":"1496-1503","source":"Crossref","is-referenced-by-count":84,"title":["Prognostic Factors for Leukemic Induction Failure in Children With Acute Lymphoblastic Leukemia and Outcome After Salvage Therapy: The FRALLE 93 Study"],"prefix":"10.1200","volume":"26","author":[{"given":"Caroline","family":"Oudot","sequence":"first","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Fran\u00e7oise","family":"Auclerc","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Levy","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Porcher","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Piguet","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Perel","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Gandemer","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Debre","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Vermylen","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Pautard","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Berger","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Schmitt","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Leblanc","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Cayuela","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Socie","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Michel","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Leverger","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Baruchel","sequence":"additional","affiliation":[{"name":"From the Service d\u2019H\u00e9matologie et Oncologie P\u00e9diatrique, H\u00f4pital M\u00e8re-Enfant, Limoges; Service de P\u00e9diatrie \u00e0 Orientation H\u00e9matologique; Centre d\u2019Investigations Cliniques; L\u2019Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U717; D\u00e9partement de Biostatistique et Informatique M\u00e9dicales; Laboratoire d\u2019H\u00e9matologie Mol\u00e9culaire, Service de Greffe de Moelle; H\u00f4pital St Louis, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP); Service d\u2019H\u00e9matologie P\u00e9diatrique, H\u00f4pital Necker Enfants Malades, AP-HP; Service..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023001"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401939"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401961"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401974"},{"key":"R5","unstructured":"Schrappe M, Reiter A, Ludwig WD, et al: Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: Results of trial ALL-BFM 90\u2014German-Austrian-Swiss ALL-BFM Study Group. Blood 95:3310,2000-3322,"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.5.1211"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.9.1939"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.9.3122.3122"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990315)85:6<1395::AID-CNCR25>3.0.CO;2-2"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200110000-00004"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950140314"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.4.1292.bloodjournal8641292"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401768"},{"key":"R14","unstructured":"Ribera JM, Ortega JJ, Oriol A, et al: Prognostic value of karyotypic analysis in children and adults with high-risk acute lymphoblastic leukemia included in the PETHEMA ALL-93 trial. Haematologica 87:154,2002-165,"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.116"},{"key":"R16","unstructured":"Schrappe M: Evolution of BFM trials for childhood ALL. Ann Hematol 83:S121,2004-S123,  (suppl 1)"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61126-X"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198609113151101"},{"key":"R22","unstructured":"Pui CH, Simone JV, Hancock ML, et al: Impact of three methods of treatment intensification on acute lymphoblastic leukemia in children: Long-term results of St Jude total therapy study X. Leukemia 6:150,1992-157,"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.3.527"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.4.740"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Chessells JM: Intensification of treatment and survival in ALL children. Lancet 348:143,1995-148,","DOI":"10.1016\/S0140-6736(95)90164-7"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.3.911"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.6.2222"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802193380803"},{"key":"R29","unstructured":"Kamps WA, Bokkerink JP, Hahlen K, et al: Intensive treatment of children with acute lymphoblastic leukemia according to ALL-BFM-86 without cranial radiotherapy: Results of Dutch Childhood Leukemia Study Group Protocol ALL-7 (1988-1991). Blood 94:1226,1999-1236,"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.2.445"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.7.2412"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.2.420"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402489"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1616"},{"key":"R35","unstructured":"Arico M, Conter V, Valsecchi MG, et al: Treatment reduction in highly selected standard-risk childhood acute lymphoblastic leukemia: The AIEOP ALL-9501 study. Haematologica 90:1186,2005-1191,"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02728.x"},{"key":"R37","doi-asserted-by":"crossref","unstructured":"Schaison G, Olive D, Leverger G, et al: Treatment of acute lymphoblastic leukemia: Protocol Fralle 83-87. Haematol Blood Transfus 33:467,1990-472,","DOI":"10.1007\/978-3-642-74643-7_84"},{"key":"R38","unstructured":"Chessells JM, Bailey CC, Richards S: MRC UKALL X. The UK protocol for childhood ALL: 1985-1990. Leukemia 2:S157,1992-S161,  (suppl 2)"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901015)66:8<1671::AID-CNCR2820660803>3.0.CO;2-E"},{"key":"R40","unstructured":"Mehta J, Powles R, Horton C, et al: Bone marrow transplantation for primary refractory acute leukemia. Bone Marrow Transplant 14:415,1994-418,"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.10.2497"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980201)82:3<600::AID-CNCR24>3.0.CO;2-4"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10164"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.3.489.489"},{"key":"R45","unstructured":"Schrappe M, Arico M, Harbott J, et al: Philadelphia chromosome positive childhood acute lymphoblastic leukemia: Good initial steroid response allows early prediction of a favorable treatment outcome. Blood 92:2730,1998-2741,"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004063421402"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3032"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1389"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404320"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-011908"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971101)80:9<1717::AID-CNCR4>3.0.CO;2-B"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.1.43"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.12.1807"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00818.x"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb03313.x"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2854"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(01)00516-2"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1156"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.1.135.135"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950140311"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400959"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.9.998"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801015)46:8<1727::AID-CNCR2820460804>3.0.CO;2-4"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb03252.x"},{"key":"R65","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66998-X"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808273390904"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)10295-1"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403348"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)04058-6"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.8.2691"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0006"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401780"},{"key":"R73","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3243"},{"key":"R74","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033513"},{"key":"R75","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-059790"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2007.12.2820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T22:39:06Z","timestamp":1653518346000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2007.12.2820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,20]]},"references-count":73,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,3,20]]}},"alternative-id":["10.1200\/JCO.2007.12.2820"],"URL":"https:\/\/doi.org\/10.1200\/jco.2007.12.2820","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,20]]}}}